Gene description for FBN2
Gene name fibrillin 2
Gene symbol FBN2
Other names/aliases CCA
DA9
EOMD
Species Homo sapiens
 Database cross references - FBN2
ExoCarta ExoCarta_2201
Vesiclepedia VP_2201
Entrez Gene 2201
HGNC 3604
MIM 612570
UniProt P35556  
 FBN2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
 Gene ontology annotations for FBN2
Molecular Function
    hormone activity GO:0005179 IDA
    hormone activity GO:0005179 IEA
    extracellular matrix structural constituent GO:0005201 IBA
    extracellular matrix structural constituent GO:0005201 RCA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    extracellular matrix constituent conferring elasticity GO:0030023 IC
Biological Process
    placenta development GO:0001890 IDA
    signal transduction GO:0007165 IEA
    anatomical structure morphogenesis GO:0009653 IBA
    embryonic limb morphogenesis GO:0030326 IEA
    positive regulation of bone mineralization GO:0030501 ISS
    sequestering of TGFbeta in extracellular matrix GO:0035583 ISS
    glucose homeostasis GO:0042593 ISS
    camera-type eye development GO:0043010 IEP
    positive regulation of osteoblast differentiation GO:0045669 ISS
    embryonic eye morphogenesis GO:0048048 IEP
    bone trabecula formation GO:0060346 ISS
    regulation of trophoblast cell migration GO:1901163 IDA
Subcellular Localization
    microfibril GO:0001527 IDA
    microfibril GO:0001527 TAS
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IDA
    extracellular matrix GO:0031012 IBA
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified FBN2 in exosomes
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FBN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SP1  
Affinity Capture-MS Homo sapiens
2 DEFB125  
Affinity Capture-MS Homo sapiens
3 VWCE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SFRP4 6424
Affinity Capture-MS Homo sapiens
5 HOOK1  
Proximity Label-MS Homo sapiens
6 PRDM1  
Affinity Capture-MS Homo sapiens
7 PRG3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 NOTCH2 4853
Affinity Capture-MS Homo sapiens
9 TRIM33 51592
Affinity Capture-MS Homo sapiens
10 PDIA4 9601
Proximity Label-MS Homo sapiens
11 AURKA 6790
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 LTBP2 4053
Affinity Capture-MS Homo sapiens
13 TRIM66  
Affinity Capture-MS Homo sapiens
14 WNT7A  
Affinity Capture-MS Homo sapiens
15 KLKB1 3818
Affinity Capture-MS Homo sapiens
16 PRG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 HRG 3273
Affinity Capture-MS Homo sapiens
18 RPL10 6134
Affinity Capture-MS Homo sapiens
19 PTEN 5728
Affinity Capture-MS Homo sapiens
20 Htt  
Affinity Capture-MS Mus musculus
21 FBXO6 26270
Affinity Capture-MS Homo sapiens
22 CUL3 8452
Affinity Capture-MS Homo sapiens
23 ZNF224  
Affinity Capture-MS Homo sapiens
24 ADAMTSL1 92949
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 MFAP5  
Affinity Capture-MS Homo sapiens
26 FAM19A3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 TRIM37  
Proximity Label-MS Homo sapiens
28 WDR76  
Affinity Capture-MS Homo sapiens
29 TRIM68 55128
Affinity Capture-MS Homo sapiens
30 ZFP41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ZNF408  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 NTN5  
Affinity Capture-MS Homo sapiens
33 FBXO2 26232
Affinity Capture-MS Homo sapiens
34 KLF8  
Affinity Capture-MS Homo sapiens
35 ELN 2006
Reconstituted Complex Homo sapiens
36 THBS1 7057
Two-hybrid Homo sapiens
37 BRD1 23774
Affinity Capture-MS Homo sapiens
38 ST14 6768
Affinity Capture-MS Homo sapiens
39 MATN2 4147
Reconstituted Complex Homo sapiens
40 SP7  
Affinity Capture-MS Homo sapiens
41 LYPD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 FOXD4L6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 GREM2 64388
Affinity Capture-MS Homo sapiens
44 IGFL3  
Affinity Capture-MS Homo sapiens
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