Gene description for FBN2
Gene name fibrillin 2
Gene symbol FBN2
Other names/aliases CCA
Species Homo sapiens
 Database cross references - FBN2
ExoCarta ExoCarta_2201
Entrez Gene 2201
HGNC 3604
MIM 612570
UniProt P35556  
 FBN2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for FBN2
Molecular Function
    extracellular matrix structural constituent GO:0005201 IEA
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of osteoblast differentiation GO:0045669 ISS
    anatomical structure morphogenesis GO:0009653 TAS
    positive regulation of bone mineralization GO:0030501 ISS
    sequestering of TGFbeta in extracellular matrix GO:0035583 ISS
    regulation of cellular response to growth factor stimulus GO:0090287 IBA
    bone trabecula formation GO:0060346 ISS
    embryonic limb morphogenesis GO:0030326 IEA
    extracellular matrix organization GO:0030198 TAS
    extracellular matrix disassembly GO:0022617 TAS
Subcellular Localization
    microfibril GO:0001527 TAS
    extracellular region GO:0005576 TAS
    extracellular matrix GO:0031012 IDA
 Experiment description of studies that identified FBN2 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for FBN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MATN2 4147
Reconstituted Complex Homo sapiens
2 MFAP5  
Two-hybrid Homo sapiens
3 ELN  
Reconstituted Complex Homo sapiens
4 FBN1 2200
Invivo Homo sapiens
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