Gene description for Prnp
Gene name	prion protein
Gene symbol	Prnp
Other names/aliases	AA960666 AI325101 CD230 PrP PrP PrPC PrPSc Prn-i Prn-p Sinc prP27-30 prP33-35C
Species	Mus musculus
Database cross references - Prnp
ExoCarta	ExoCarta_19122
Vesiclepedia	VP_19122
Entrez Gene	19122
UniProt	P04925
Prnp identified in sEVs derived from the following tissue/cell type
Mov neuroglial cells	15210972

Gene ontology annotations for Prnp

Molecular Function     amyloid-beta binding GO:0001540 IDA     amyloid-beta binding GO:0001540 ISO     amyloid-beta binding GO:0001540 TAS     protease binding GO:0002020 IPI     copper ion binding GO:0005507 IDA     copper ion binding GO:0005507 ISO     copper ion binding GO:0005507 ISS     protein binding GO:0005515 IPI     lamin binding GO:0005521 IEA     lamin binding GO:0005521 ISO     glycosaminoglycan binding GO:0005539 IDA     microtubule binding GO:0008017 IEA     microtubule binding GO:0008017 ISO     tubulin binding GO:0015631 ISO     aspartic-type endopeptidase inhibitor activity GO:0019828 IDA     type 5 metabotropic glutamate receptor binding GO:0031802 IPI     type 5 metabotropic glutamate receptor binding GO:0031802 ISO     signaling receptor activity GO:0038023 IMP     identical protein binding GO:0042802 IPI     identical protein binding GO:0042802 ISO     ATP-dependent protein binding GO:0043008 IEA     ATP-dependent protein binding GO:0043008 ISO     transmembrane transporter binding GO:0044325 IEA     transmembrane transporter binding GO:0044325 ISO     protein-containing complex binding GO:0044877 IPI     protein-containing complex binding GO:0044877 ISO     metal ion binding GO:0046872 EXP     metal ion binding GO:0046872 IDA     protein-folding chaperone binding GO:0051087 IEA     protein-folding chaperone binding GO:0051087 ISO     molecular adaptor activity GO:0060090 EXP     molecular adaptor activity GO:0060090 IPI     molecular adaptor activity GO:0060090 ISO     molecular condensate scaffold activity GO:0140693 EXP     molecular condensate scaffold activity GO:0140693 IDA     molecular condensate scaffold activity GO:0140693 ISO     cupric ion binding GO:1903135 IMP     cuprous ion binding GO:1903136 IEA     cuprous ion binding GO:1903136 ISO Biological Process     negative regulation of protein phosphorylation GO:0001933 IMP     nucleobase-containing compound metabolic process GO:0006139 TAS     intracellular copper ion homeostasis GO:0006878 TAS     response to oxidative stress GO:0006979 IDA     learning or memory GO:0007611 IGI     learning or memory GO:0007611 ISO     protein destabilization GO:0031648 IEA     protein destabilization GO:0031648 ISO     activation of protein kinase activity GO:0032147 IGI     negative regulation of type II interferon production GO:0032689 IMP     negative regulation of interleukin-17 production GO:0032700 IMP     negative regulation of interleukin-2 production GO:0032703 IMP     regulation of protein localization GO:0032880 IMP     amyloid precursor protein metabolic process GO:0042982 IGI     negative regulation of apoptotic process GO:0043066 IGI     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of DNA-binding transcription factor activity GO:0043433 IMP     positive regulation of neuron apoptotic process GO:0043525 IEA     positive regulation of neuron apoptotic process GO:0043525 ISO     negative regulation of activated T cell proliferation GO:0046007 IMP     response to cadmium ion GO:0046686 IEA     response to cadmium ion GO:0046686 ISO     response to copper ion GO:0046688 ISO     regulation of peptidyl-tyrosine phosphorylation GO:0050730 IGI     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IMP     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     positive regulation of calcium-mediated signaling GO:0050850 IGI     positive regulation of calcium-mediated signaling GO:0050850 ISO     negative regulation of T cell receptor signaling pathway GO:0050860 IMP     protein homooligomerization GO:0051260 IEA     negative regulation of calcineurin-NFAT signaling cascade GO:0070885 IMP     cellular response to copper ion GO:0071280 ISO     cellular response to xenobiotic stimulus GO:0071466 IDA     positive regulation of protein targeting to membrane GO:0090314 IGI     negative regulation of long-term synaptic potentiation GO:1900272 IEA     negative regulation of long-term synaptic potentiation GO:1900272 ISO     regulation of glutamate receptor signaling pathway GO:1900449 IGI     positive regulation of glutamate receptor signaling pathway GO:1900451 IEA     positive regulation of glutamate receptor signaling pathway GO:1900451 ISO     regulation of potassium ion transmembrane transport GO:1901379 IGI     negative regulation of amyloid-beta formation GO:1902430 IGI     negative regulation of dendritic spine maintenance GO:1902951 IGI     negative regulation of amyloid precursor protein catabolic process GO:1902992 IGI     positive regulation of protein localization to plasma membrane GO:1903078 IMP     positive regulation of protein localization to plasma membrane GO:1903078 ISO     response to amyloid-beta GO:1904645 IGI     cellular response to amyloid-beta GO:1904646 IGI     cellular response to amyloid-beta GO:1904646 ISO     regulation of calcium ion import across plasma membrane GO:1905664 IGI     neuron projection maintenance GO:1990535 IGI Subcellular Localization     mitochondrial outer membrane GO:0005741 ISO     endoplasmic reticulum GO:0005783 IDA     Golgi apparatus GO:0005794 IDA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 TAS     cell surface GO:0009986 IDA     cell surface GO:0009986 ISO     postsynaptic density GO:0014069 IEA     postsynaptic density GO:0014069 ISO     membrane GO:0016020 IDA     inclusion body GO:0016234 IEA     inclusion body GO:0016234 ISO     dendrite GO:0030425 IDA     dendrite GO:0030425 IDA     dendrite GO:0030425 ISO     nuclear membrane GO:0031965 IEA     nuclear membrane GO:0031965 ISO     terminal bouton GO:0043195 IDA     intracellular membrane-bounded organelle GO:0043231 ISO     membrane raft GO:0045121 IDA     membrane raft GO:0045121 IMP     membrane raft GO:0045121 ISO     membrane raft GO:0045121 TAS     side of membrane GO:0098552 IEA