Gene description for CYBA
Gene name	cytochrome b-245, alpha polypeptide
Gene symbol	CYBA
Other names/aliases	p22-PHOX
Species	Homo sapiens
Database cross references - CYBA
ExoCarta	ExoCarta_1535
Entrez Gene	1535
HGNC	2577
MIM	608508
UniProt	P13498
CYBA identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for CYBA

Molecular Function     superoxide-generating NADPH oxidase activity GO:0016175 IMP     protein heterodimerization activity GO:0046982 IPI     SH3 domain binding GO:0017124 IPI     metal ion binding GO:0046872 IEA     protein binding GO:0005515 IPI     electron carrier activity GO:0009055 TAS     heme binding GO:0020037 IEA Biological Process     cytochrome complex assembly GO:0017004 IDA     cellular response to mechanical stimulus GO:0071260 IEA     innate immune response GO:0045087 IMP     response to drug GO:0042493 IEA     positive regulation of phagocytosis GO:0050766 IDA     regulation of release of sequestered calcium ion into cytosol GO:0051279 IEA     small GTPase mediated signal transduction GO:0007264 TAS     respiratory burst GO:0045730 IMP     interaction with host GO:0051701 TAS     positive regulation of reactive oxygen species biosynthetic process GO:1903428 IDA     positive regulation of mucus secretion GO:0070257 IEA     response to interleukin-1 GO:0070555 IEA     superoxide metabolic process GO:0006801 IMP     positive regulation of tumor necrosis factor production GO:0032760 IDA     cellular response to organic cyclic compound GO:0071407 IEA     response to nutrient levels GO:0031667 IEA     antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 TAS     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     antigen processing and presentation of peptide antigen via MHC class I GO:0002474 TAS     smooth muscle hypertrophy GO:0014895 ISS     cellular response to amino acid stimulus GO:0071230 IEA     antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 TAS     positive regulation of cell growth GO:0030307 IEA     superoxide anion generation GO:0042554 IMP     cellular response to gamma radiation GO:0071480 IEA     cellular response to tumor necrosis factor GO:0071356 IEA     phagosome maturation GO:0090382 TAS     oxidation-reduction process GO:0055114 IMP     negative regulation of glomerular filtration by angiotensin GO:0003106 IEA     cellular response to glucose stimulus GO:0071333 IEA     positive regulation of interleukin-6 production GO:0032755 IDA     positive regulation of toll-like receptor 2 signaling pathway GO:0034137 IDA     hydrogen peroxide biosynthetic process GO:0050665 ISS     inflammatory response GO:0006954 IMP     positive regulation of defense response to bacterium GO:1900426 IDA     positive regulation of endothelial cell proliferation GO:0001938 IEA Subcellular Localization     NADPH oxidase complex GO:0043020 IMP     Golgi apparatus GO:0005794 IEA     secretory granule GO:0030141 TAS     neuronal cell body GO:0043025 IEA     apical plasma membrane GO:0016324 IEA     mitochondrion GO:0005739 IEA     plasma membrane GO:0005886 TAS     perinuclear endoplasmic reticulum GO:0097038 IEA     membrane GO:0016020 IDA     dendrite GO:0030425 IEA     endosome GO:0005768 IEA     phagocytic vesicle membrane GO:0030670 TAS