Gene description for Park7
Gene name parkinson protein 7
Gene symbol Park7
Other names/aliases CAP1
DJ-1
Dj1
SP22
Species Rattus norvegicus
 Database cross references - Park7
ExoCarta ExoCarta_117287
Entrez Gene 117287
UniProt O88767  
 Park7 identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Park7
Molecular Function
    glyoxalase (glycolic acid-forming) activity GO:1990422 ISS
    peptidase activity GO:0008233 ISS
    protein homodimerization activity GO:0042803 ISS
    molecular_function GO:0003674 ND
    repressing transcription factor binding GO:0070491 ISS
    oxidoreductase activity, acting on peroxide as acceptor GO:0016684 ISO
    copper ion binding GO:0005507 ISS
    protein binding GO:0005515 IPI
    cytokine binding GO:0019955 ISS
    small protein activating enzyme binding GO:0044388 ISS
    kinase binding GO:0019900 ISO
    androgen receptor binding GO:0050681 ISS
    scaffold protein binding GO:0097110 ISS
    transcription factor binding GO:0008134 ISS
    cupric ion binding GO:1903135 ISS
    double-stranded DNA binding GO:0003690 ISO
    ubiquitin-like protein conjugating enzyme binding GO:0044390 ISS
    identical protein binding GO:0042802 ISO
    tyrosine 3-monooxygenase activator activity GO:0036470 ISS
    mRNA binding GO:0003729 ISS
    glyoxalase III activity GO:0019172 ISS
    cuprous ion binding GO:1903136 ISS
    transcription coactivator activity GO:0003713 ISS
    superoxide dismutase copper chaperone activity GO:0016532 ISS
    single-stranded DNA binding GO:0003697 ISO
    ubiquitin-specific protease binding GO:1990381 ISS
    mercury ion binding GO:0045340 ISS
    peroxiredoxin activity GO:0051920 ISO
    receptor binding GO:0005102 ISS
    L-dopa decarboxylase activator activity GO:0036478 ISS
    enzyme binding GO:0019899 ISO
Biological Process
    positive regulation of superoxide dismutase activity GO:1901671 ISS
    response to oxidative stress GO:0006979 IMP
    fertilization GO:0009566 TAS
    protein stabilization GO:0050821 ISS
    positive regulation of transcription regulatory region DNA binding GO:2000679 ISO
    negative regulation of hydrogen peroxide-induced cell death GO:1903206 ISO
    positive regulation of pyrroline-5-carboxylate reductase activity GO:1903168 ISS
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISS
    negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway GO:1903384 ISO
    regulation of inflammatory response GO:0050727 ISS
    cellular response to hydrogen peroxide GO:0070301 ISS
    single fertilization GO:0007338 IEA
    positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 ISO
    detoxification of copper ion GO:0010273 ISS
    regulation of neuron apoptotic process GO:0043523 ISS
    negative regulation of cell death GO:0060548 ISS
    enzyme active site formation via L-cysteine sulfinic acid GO:0018323 ISO
    mitochondrion organization GO:0007005 ISS
    positive regulation of reactive oxygen species biosynthetic process GO:1903428 ISO
    negative regulation of protein ubiquitination GO:0031397 ISS
    response to drug GO:0042493 IEP
    negative regulation of protein kinase activity GO:0006469 ISS
    methylglyoxal catabolic process to D-lactate GO:0019243 ISS
    regulation of mitochondrial membrane potential GO:0051881 ISS
    positive regulation of mitochondrial electron transport, NADH to ubiquinone GO:1902958 ISS
    regulation of androgen receptor signaling pathway GO:0060765 ISS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS
    response to hydrogen peroxide GO:0042542 ISO
    negative regulation of hydrogen peroxide-induced neuron death GO:1903208 ISO
    negative regulation of protein binding GO:0032091 ISS
    dopamine uptake involved in synaptic transmission GO:0051583 ISO
    positive regulation of oxidative phosphorylation uncoupler activity GO:2000277 ISS
    negative regulation of protein catabolic process GO:0042177 ISO
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:2001268 ISS
    negative regulation of protein K48-linked deubiquitination GO:1903094 ISS
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 ISO
    cellular response to oxidative stress GO:0034599 ISS
    negative regulation of protein export from nucleus GO:0046826 ISS
    negative regulation of protein phosphorylation GO:0001933 ISS
    detoxification of mercury ion GO:0050787 ISS
    membrane depolarization GO:0051899 ISO
    positive regulation of tyrosine 3-monooxygenase activity GO:1903178 ISS
    negative regulation of apoptotic process GO:0043066 ISO
    negative regulation of protein acetylation GO:1901984 ISS
    inflammatory response GO:0006954 IEA
    positive regulation of gene expression GO:0010628 ISO
    positive regulation of interleukin-8 production GO:0032757 ISS
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 ISS
    negative regulation of gene expression GO:0010629 ISO
    lactate biosynthetic process GO:0019249 ISS
    negative regulation of oxidative stress-induced neuron death GO:1903204 ISO
    synaptic transmission, dopaminergic GO:0001963 ISO
    negative regulation of oxidative stress-induced cell death GO:1903202 ISO
    negative regulation of protein sumoylation GO:0033234 ISS
    negative regulation of neuron apoptotic process GO:0043524 ISS
    membrane hyperpolarization GO:0060081 ISO
    cellular response to reactive oxygen species GO:0034614 ISO
    negative regulation of ubiquitin-protein transferase activity GO:0051444 ISO
    positive regulation of protein homodimerization activity GO:0090073 ISS
    regulation of TRAIL receptor biosynthetic process GO:0045560 ISO
    positive regulation of protein localization to nucleus GO:1900182 ISS
    positive regulation of dopamine biosynthetic process GO:1903181 ISS
    negative regulation of TRAIL-activated apoptotic signaling pathway GO:1903122 ISS
    glyoxal catabolic process GO:1903190 ISS
    positive regulation of androgen receptor activity GO:2000825 ISS
    proteolysis GO:0006508 IEA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO
    positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902177 ISO
    adult locomotory behavior GO:0008344 ISO
    positive regulation of L-dopa biosynthetic process GO:1903197 ISS
    autophagy GO:0006914 IEA
    negative regulation of neuron death GO:1901215 ISO
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 ISO
    hydrogen peroxide metabolic process GO:0042743 ISS
    cellular response to glyoxal GO:0036471 ISS
    negative regulation of ubiquitin-specific protease activity GO:2000157 ISS
    positive regulation of L-dopa decarboxylase activity GO:1903200 ISS
    glycolate biosynthetic process GO:0046295 ISS
    protein deglycosylation GO:0006517 ISS
Subcellular Localization
    PML body GO:0016605 ISS
    neuron projection GO:0043005 ISO
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IEA
    mitochondrial matrix GO:0005759 ISO
    extracellular exosome GO:0070062 ISS
    mitochondrion GO:0005739 ISS
    cytoplasm GO:0005737 ISS
    nucleus GO:0005634 ISS
    cell body GO:0044297 ISO
    mitochondrial intermembrane space GO:0005758 ISO
    chromatin GO:0000785 ISO
    membrane raft GO:0045121 IEA
    axon GO:0030424 IDA
    mitochondrial respiratory chain complex I GO:0005747 ISS
    endoplasmic reticulum GO:0005783 ISO
 Experiment description of studies that identified Park7 in exosomes
1
Experiment ID 192
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
CD63|CD81|FLOT
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Park7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Park7 is involved
No pathways found





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