Gene description for VAMP2
Gene name vesicle-associated membrane protein 2 (synaptobrevin 2)
Gene symbol VAMP2
Other names/aliases SYB2
VAMP-2
Species Homo sapiens
 Database cross references - VAMP2
ExoCarta ExoCarta_6844
Vesiclepedia VP_6844
Entrez Gene 6844
HGNC 12643
MIM 185881
UniProt P63027  
 VAMP2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Neuroblastoma cells 25944692    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Prostate cancer cells 25844599    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Thymus 23844026    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for VAMP2
Molecular Function
    SNARE binding GO:0000149 ISS
    SNAP receptor activity GO:0005484 IBA
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 ISS
    phospholipid binding GO:0005543 ISS
    syntaxin-1 binding GO:0017075 IBA
    syntaxin-1 binding GO:0017075 ISS
    syntaxin binding GO:0019905 IPI
    syntaxin binding GO:0019905 ISS
    calcium-dependent protein binding GO:0048306 ISS
Biological Process
    exocytosis GO:0006887 TAS
    vesicle fusion GO:0006906 IBA
    vesicle fusion GO:0006906 IMP
    response to glucose GO:0009749 ISS
    protein transport GO:0015031 ISS
    synaptic vesicle exocytosis GO:0016079 ISS
    synaptic vesicle exocytosis GO:0016079 TAS
    vesicle-mediated transport GO:0016192 ISS
    calcium-ion regulated exocytosis GO:0017156 ISS
    regulation of exocytosis GO:0017157 ISS
    cellular response to insulin stimulus GO:0032869 ISS
    SNARE complex assembly GO:0035493 IBA
    Golgi to plasma membrane protein transport GO:0043001 ISS
    eosinophil degranulation GO:0043308 IMP
    neutrophil degranulation GO:0043312 IMP
    natural killer cell degranulation GO:0043320 IMP
    synaptic vesicle endocytosis GO:0048488 ISS
    long-term synaptic potentiation GO:0060291 ISS
    regulation of vesicle-mediated transport GO:0060627 ISS
    membrane fusion GO:0061025 ISS
    protein-containing complex assembly GO:0065003 ISS
    mucus secretion GO:0070254 IMP
    positive regulation of intracellular protein transport GO:0090316 ISS
    regulation of delayed rectifier potassium channel activity GO:1902259 ISS
    regulation of histamine secretion by mast cell GO:1903593 IMP
Subcellular Localization
    trans-Golgi network GO:0005802 ISS
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    synaptic vesicle GO:0008021 ISS
    synaptic vesicle GO:0008021 TAS
    voltage-gated potassium channel complex GO:0008076 ISS
    membrane GO:0016020 IDA
    clathrin-coated vesicle GO:0030136 IDA
    secretory granule GO:0030141 ISS
    secretory granule membrane GO:0030667 IDA
    secretory granule membrane GO:0030667 TAS
    clathrin-coated endocytic vesicle membrane GO:0030669 TAS
    synaptic vesicle membrane GO:0030672 ISS
    synaptic vesicle membrane GO:0030672 TAS
    SNARE complex GO:0031201 IBA
    SNARE complex GO:0031201 IDA
    SNARE complex GO:0031201 TAS
    cytoplasmic vesicle GO:0031410 ISS
    vesicle GO:0031982 IDA
    zymogen granule membrane GO:0042589 ISS
    neuron projection GO:0043005 ISS
    intracellular membrane-bounded organelle GO:0043231 ISS
    neuron projection terminus GO:0044306 ISS
    synapse GO:0045202 ISS
    perinuclear region of cytoplasm GO:0048471 ISS
    clathrin-sculpted glutamate transport vesicle membrane GO:0060203 TAS
    clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane GO:0061202 TAS
    synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex GO:0070032 ISS
    synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex GO:0070033 ISS
    synaptobrevin 2-SNAP-25-syntaxin-1a complex GO:0070044 ISS
    clathrin-sculpted monoamine transport vesicle membrane GO:0070083 TAS
 Experiment description of studies that identified VAMP2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
9
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
13
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 196
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 197
MISEV standards
✔
EM
Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors "Raj DA, Fiume I, Capasso G, Pocsfalvi G."
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for VAMP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Co-fractionation Homo sapiens
2 SLC30A8  
Two-hybrid Homo sapiens
3 OCLN 100506658
Proximity Label-MS Homo sapiens
4 SNAP23 8773
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
5 VAPA 9218
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
6 MARCKS 4082
Proximity Label-MS Homo sapiens
7 LAMP3  
Proximity Label-MS Homo sapiens
8 NAPA 8775
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 UBE2M 9040
Co-fractionation Homo sapiens
10 ATP13A2  
Two-hybrid Homo sapiens
11 RAB11B 9230
Affinity Capture-MS Homo sapiens
12 GOLGA1  
Proximity Label-MS Homo sapiens
13 NTNG1  
Affinity Capture-MS Homo sapiens
14 GJD3  
Proximity Label-MS Homo sapiens
15 LAMP2 3920
Proximity Label-MS Homo sapiens
16 CALM1 801
Co-fractionation Homo sapiens
17 STX4 6810
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
18 STX11 8676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
19 SEPT9 10801
Co-fractionation Homo sapiens
20 TAX1BP3 30851
Co-fractionation Homo sapiens
21 STX1A 6804
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Far Western Homo sapiens
22 WASH3P  
Affinity Capture-MS Homo sapiens
23 NUFIP1  
Affinity Capture-MS Homo sapiens
24 RAB3B 5865
Proximity Label-MS Homo sapiens
25 STX8 9482
Affinity Capture-MS Homo sapiens
26 MUC1 4582
Affinity Capture-MS Homo sapiens
27 STX7 8417
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
28 CALM3 808
Co-fractionation Homo sapiens
29 DNAJB1 3337
Affinity Capture-MS Homo sapiens
30 LAMTOR3 8649
Co-fractionation Homo sapiens
31 STX6 10228
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SLC30A5 64924
Co-fractionation Homo sapiens
33 CPLX1 10815
Co-crystal Structure Homo sapiens
34 STXBP3 6814
Reconstituted Complex Homo sapiens
35 ABCC2 1244
Co-fractionation Homo sapiens
36 RAB35 11021
Proximity Label-MS Homo sapiens
37 HSD17B4 3295
Co-fractionation Homo sapiens
38 USP7 7874
Co-fractionation Homo sapiens
39 EBAG9 9166
Proximity Label-MS Homo sapiens
40 TFRC 7037
Affinity Capture-MS Homo sapiens
41 STX12 23673
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 METTL7A 25840
Proximity Label-MS Homo sapiens
43 LAMTOR1 55004
Proximity Label-MS Homo sapiens
44 HSPA8 3312
Co-fractionation Homo sapiens
45 CALM2 805
Co-fractionation Homo sapiens
46 SRGAP3  
Affinity Capture-MS Homo sapiens
47 SCFD1 23256
Co-fractionation Homo sapiens
48 PRDX5 25824
Co-fractionation Homo sapiens
49 GJA1 2697
Proximity Label-MS Homo sapiens
50 CXADR 1525
Proximity Label-MS Homo sapiens
51 JAGN1 84522
Two-hybrid Homo sapiens
52 SFXN3 81855
Co-fractionation Homo sapiens
53 LYN 4067
Proximity Label-MS Homo sapiens
54 UBAP2L 9898
Co-fractionation Homo sapiens
55 MCAM 4162
Proximity Label-MS Homo sapiens
56 BAG6 7917
Reconstituted Complex Homo sapiens
57 RAB4A 5867
Proximity Label-MS Homo sapiens
58 ASNA1 439
Reconstituted Complex Homo sapiens
59 DIRAS3  
Proximity Label-MS Homo sapiens
60 CENPM  
Affinity Capture-MS Homo sapiens
61 LAMP1 3916
Proximity Label-MS Homo sapiens
62 SSUH2  
Affinity Capture-MS Homo sapiens
63 HUWE1 10075
Affinity Capture-MS Homo sapiens
64 NAPG 8774
Affinity Capture-MS Homo sapiens
65 VMA21  
Two-hybrid Homo sapiens
66 ARL13B 200894
Two-hybrid Homo sapiens
67 SLC14A1  
Affinity Capture-MS Homo sapiens
68 FLOT2 2319
Co-fractionation Homo sapiens
69 SCN3B  
Two-hybrid Homo sapiens
70 ELOVL5 60481
Proximity Label-MS Homo sapiens
71 WDFY1 57590
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 TMEM185A  
Affinity Capture-MS Homo sapiens
73 VAMP3 9341
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
74 VAPB 9217
Reconstituted Complex Homo sapiens
75 VAMP8 8673
Reconstituted Complex Homo sapiens
76 RAB5A 5868
Proximity Label-MS Homo sapiens
77 S100A16 140576
Co-fractionation Homo sapiens
78 IQCB1  
Affinity Capture-MS Homo sapiens
79 MARCH8  
Two-hybrid Homo sapiens
80 ERGIC3 51614
Two-hybrid Homo sapiens
81 BCAP31 10134
Reconstituted Complex Homo sapiens
82 HSD3B7 80270
Proximity Label-MS Homo sapiens
83 SF1 7536
Co-fractionation Homo sapiens
84 TDP1  
Co-fractionation Homo sapiens
85 CCDC155  
Two-hybrid Homo sapiens
86 HSD17B13  
Two-hybrid Homo sapiens
87 LPAR1 1902
Affinity Capture-MS Homo sapiens
88 TIMM50 92609
Co-fractionation Homo sapiens
89 SYP  
Affinity Capture-MS Homo sapiens
90 TMEM86B  
Two-hybrid Homo sapiens
91 STX1B 112755
Two-hybrid Homo sapiens
92 ARF6 382
Proximity Label-MS Homo sapiens
93 ANKFY1 51479
Proximity Label-MS Homo sapiens
94 RABAC1 10567
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
95 VAMP1 6843
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
96 ATP2A1 487
Proximity Label-MS Homo sapiens
97 HIBADH 11112
Two-hybrid Homo sapiens
98 SCGN  
Affinity Capture-MS Homo sapiens
99 RAB9A 9367
Proximity Label-MS Homo sapiens
100 B3GAT1  
Proximity Label-MS Homo sapiens
101 ACAD9 28976
Co-fractionation Homo sapiens
102 RHOB 388
Proximity Label-MS Homo sapiens
103 TPCN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 ATP6V0A1 535
Co-fractionation Homo sapiens
105 UBXN1 51035
Co-fractionation Homo sapiens
106 FLOT1 10211
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
107 CREB3L1  
Two-hybrid Homo sapiens
108 ATP4A 495
Affinity Capture-MS Homo sapiens
109 STX2 2054
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
110 SNCA 6622
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
111 STX19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 TMED10 10972
Co-fractionation Homo sapiens
113 EXOC3 11336
Reconstituted Complex Homo sapiens
114 SLC25A6 293
Co-fractionation Homo sapiens
115 ILF3 3609
Co-fractionation Homo sapiens
116 NSF 4905
Affinity Capture-MS Homo sapiens
117 PPM1H  
Proximity Label-MS Homo sapiens
118 HSD17B11 51170
Proximity Label-MS Homo sapiens
119 HGS 9146
Affinity Capture-Western Homo sapiens
120 UBA52 7311
Co-fractionation Homo sapiens
121 RPS12 6206
Co-fractionation Homo sapiens
122 SNAP25 6616
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
123 COX8A  
Proximity Label-MS Homo sapiens
124 EBP  
Two-hybrid Homo sapiens
125 FKBP2 2286
Reconstituted Complex Homo sapiens
126 ERGIC1 57222
Proximity Label-MS Homo sapiens
127 C11orf52 91894
Proximity Label-MS Homo sapiens
128 TRAP1 10131
Co-fractionation Homo sapiens
129 RAB2A 5862
Proximity Label-MS Homo sapiens
130 SEC62 7095
Proximity Label-MS Homo sapiens
131 STX3 6809
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 RAB7A 7879
Proximity Label-MS Homo sapiens
133 RAB11A 8766
Proximity Label-MS Homo sapiens
134 DGUOK  
Affinity Capture-MS Homo sapiens
135 SYT1 6857
Affinity Capture-Western Homo sapiens
136 KRAS 3845
Proximity Label-MS Homo sapiens
137 RAB5C 5878
Proximity Label-MS Homo sapiens
138 TMEM31  
Two-hybrid Homo sapiens
139 LGALS3 3958
Affinity Capture-MS Homo sapiens
140 SYPL1 6856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 CAV1 857
Proximity Label-MS Homo sapiens
142 UNC13B 10497
Co-fractionation Homo sapiens
143 SNAP29 9342
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
144 ACAA2 10449
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which VAMP2 is involved
PathwayEvidenceSource
Acetylcholine Neurotransmitter Release Cycle TAS Reactome
Bacterial Infection Pathways TAS Reactome
Cargo recognition for clathrin-mediated endocytosis TAS Reactome
Clathrin-mediated endocytosis TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Disease TAS Reactome
Dopamine Neurotransmitter Release Cycle TAS Reactome
GABA synthesis, release, reuptake and degradation TAS Reactome
Glutamate Neurotransmitter Release Cycle TAS Reactome
Golgi Associated Vesicle Biogenesis TAS Reactome
Immune System TAS Reactome
Infectious disease TAS Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane IEA Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane TAS Reactome
Insulin processing IEA Reactome
Integration of energy metabolism IEA Reactome
Lysosome Vesicle Biogenesis TAS Reactome
Membrane Trafficking TAS Reactome
Membrane Trafficking IEA Reactome
Metabolism IEA Reactome
Metabolism of proteins IEA Reactome
Neuronal System TAS Reactome
Neurotoxicity of clostridium toxins TAS Reactome
Neurotransmitter release cycle TAS Reactome
Norepinephrine Neurotransmitter Release Cycle TAS Reactome
Other interleukin signaling TAS Reactome
Peptide hormone metabolism IEA Reactome
Protein localization IEA Reactome
Protein localization TAS Reactome
Regulation of insulin secretion IEA Reactome
Sensory Perception IEA Reactome
Sensory processing of sound IEA Reactome
Sensory processing of sound by inner hair cells of the cochlea IEA Reactome
Serotonin Neurotransmitter Release Cycle TAS Reactome
Signaling by Interleukins TAS Reactome
Toxicity of botulinum toxin type B (botB) TAS Reactome
Toxicity of botulinum toxin type D (botD) TAS Reactome
Toxicity of botulinum toxin type F (botF) TAS Reactome
Toxicity of botulinum toxin type G (botG) TAS Reactome
Toxicity of tetanus toxin (tetX) TAS Reactome
trans-Golgi Network Vesicle Budding TAS Reactome
Translocation of SLC2A4 (GLUT4) to the plasma membrane IEA Reactome
Transmission across Chemical Synapses TAS Reactome
Uptake and actions of bacterial toxins TAS Reactome
Vesicle-mediated transport TAS Reactome
Vesicle-mediated transport IEA Reactome





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