Gene description for CCBL1
Gene name cysteine conjugate-beta lyase, cytoplasmic
Gene symbol CCBL1
Other names/aliases GTK
KAT1
KATI
Species Homo sapiens
 Database cross references - CCBL1
ExoCarta ExoCarta_883
Vesiclepedia VP_883
Entrez Gene 883
HGNC 1564
MIM 600547
UniProt Q16773  
 CCBL1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CCBL1
Molecular Function
    protein binding GO:0005515 IPI
    kynurenine-oxoglutarate transaminase activity GO:0016212 IBA
    kynurenine-oxoglutarate transaminase activity GO:0016212 IDA
    pyridoxal phosphate binding GO:0030170 IEA
    protein homodimerization activity GO:0042803 IPI
    glutamine-phenylpyruvate transaminase activity GO:0047316 IEA
    cysteine-S-conjugate beta-lyase activity GO:0047804 IDA
Biological Process
    biosynthetic process GO:0009058 IEA
    response to bacterium GO:0009617 IEA
    kynurenine metabolic process GO:0070189 IDA
    L-kynurenine catabolic process GO:0097053 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified CCBL1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CCBL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 SCLY  
Co-fractionation Homo sapiens
3 IGHG1 3500
Affinity Capture-MS Homo sapiens
4 NXF1 10482
Affinity Capture-RNA Homo sapiens
5 TRIP13 9319
Two-hybrid Homo sapiens
6 YEATS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 MBIP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 DGKQ  
Co-fractionation Homo sapiens
9 ZNF318 24149
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 IGHG2 3501
Affinity Capture-MS Homo sapiens
11 TRIM55  
Two-hybrid Homo sapiens
12 IGHG4 3503
Affinity Capture-MS Homo sapiens
13 S100A7A 338324
Affinity Capture-MS Homo sapiens
14 SHMT2 6472
Affinity Capture-RNA Homo sapiens
15 TRIM63  
Two-hybrid Homo sapiens
16 ZZZ3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 VAC14 55697
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
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