Gene description for AKR1C3
Gene name	aldo-keto reductase family 1, member C3
Gene symbol	AKR1C3
Other names/aliases	DD3 DDX HA1753 HAKRB HAKRe HSD17B5 PGFS hluPGFS
Species	Homo sapiens
Database cross references - AKR1C3
ExoCarta	ExoCarta_8644
Entrez Gene	8644
HGNC	386
MIM	603966
UniProt	P42330
AKR1C3 identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for AKR1C3

Molecular Function     retinal dehydrogenase activity GO:0001758 IDA     geranylgeranyl reductase activity GO:0045550 IDA     androsterone dehydrogenase activity GO:0047023 IDA     phenanthrene 9,10-monooxygenase activity GO:0018636 IDA     15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity GO:0047020 IDA     trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity GO:0047115 IEA     alditol:NADP+ 1-oxidoreductase activity GO:0004032 IDA     ketosteroid monooxygenase activity GO:0047086 IDA     testosterone 17-beta-dehydrogenase (NADP+) activity GO:0047045 IEA     ketoreductase activity GO:0045703 IDA     retinol dehydrogenase activity GO:0004745 IDA     indanol dehydrogenase activity GO:0047718 IEA     delta4-3-oxosteroid 5beta-reductase activity GO:0047787 IDA     aldo-keto reductase (NADP) activity GO:0004033 TAS     prostaglandin D2 11-ketoreductase activity GO:0036131 IEA     prostaglandin-F synthase activity GO:0047017 IEA     oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0016655 IDA     dihydrotestosterone 17-beta-dehydrogenase activity GO:0035410 IDA     testosterone dehydrogenase (NAD+) activity GO:0047035 IEA Biological Process     farnesol catabolic process GO:0016488 IDA     positive regulation of protein kinase B signaling GO:0051897 IDA     positive regulation of cell proliferation GO:0008284 IMP     progesterone metabolic process GO:0042448 IDA     prostaglandin metabolic process GO:0006693 TAS     renal absorption GO:0070293 NAS     arachidonic acid metabolic process GO:0019369 TAS     cellular response to corticosteroid stimulus GO:0071384 IDA     cellular response to jasmonic acid stimulus GO:0071395 IDA     male gonad development GO:0008584 IEP     cellular response to prostaglandin D stimulus GO:0071799 IDA     oxidation-reduction process GO:0055114 TAS     cellular response to calcium ion GO:0071277 IDA     cyclooxygenase pathway GO:0019371 TAS     positive regulation of reactive oxygen species metabolic process GO:2000379 IDA     cellular response to cadmium ion GO:0071276 IDA     negative regulation of retinoic acid biosynthetic process GO:1900053 IDA     phototransduction, visible light GO:0007603 TAS     steroid metabolic process GO:0008202 IEP     G-protein coupled receptor signaling pathway GO:0007186 IDA     doxorubicin metabolic process GO:0044598 IMP     protein import into nucleus, translocation GO:0000060 IDA     response to nutrient GO:0007584 IEP     cellular response to reactive oxygen species GO:0034614 IDA     positive regulation of endothelial cell apoptotic process GO:2000353 IDA     keratinocyte differentiation GO:0030216 IEP     cellular response to prostaglandin stimulus GO:0071379 IDA     daunorubicin metabolic process GO:0044597 IMP     retinoid metabolic process GO:0001523 TAS     positive regulation of cell death GO:0010942 IDA     regulation of retinoic acid receptor signaling pathway GO:0048385 IDA     retinal metabolic process GO:0042574 IDA     regulation of testosterone biosynthetic process GO:2000224 IMP     multicellular organismal macromolecule metabolic process GO:0044259 IEP     cellular response to starvation GO:0009267 IEP     testosterone biosynthetic process GO:0061370 IMP     small molecule metabolic process GO:0044281 TAS Subcellular Localization     intracellular GO:0005622 IDA     cytoplasm GO:0005737 IDA     nucleus GO:0005634 IDA     cytosol GO:0005829 TAS     extracellular exosome GO:0070062 IDA