Gene description for CACNA1B
Gene name calcium channel, voltage-dependent, N type, alpha 1B subunit
Gene symbol CACNA1B
Other names/aliases BIII
CACNL1A5
CACNN
Cav2.2
DYT23
Species Homo sapiens
 Database cross references - CACNA1B
ExoCarta ExoCarta_774
Vesiclepedia VP_774
Entrez Gene 774
HGNC 1389
MIM 601012
UniProt Q00975  
 CACNA1B identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CACNA1B
Molecular Function
    amyloid-beta binding GO:0001540 IC
    voltage-gated calcium channel activity GO:0005245 IDA
    voltage-gated calcium channel activity GO:0005245 IMP
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    high voltage-gated calcium channel activity GO:0008331 IBA
    high voltage-gated calcium channel activity GO:0008331 IMP
Biological Process
    chemical synaptic transmission GO:0007268 IBA
    modulation of chemical synaptic transmission GO:0050804 IDA
    calcium ion import across plasma membrane GO:0098703 IBA
    response to amyloid-beta GO:1904645 IDA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    voltage-gated calcium channel complex GO:0005891 IBA
    neuronal cell body GO:0043025 IBA
    synapse GO:0045202 IEA
 Experiment description of studies that identified CACNA1B in exosomes
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CACNA1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2L3 7332
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 MAP1LC3B 81631
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 RXRB 6257
Reconstituted Complex Homo sapiens
4 PDLIM5 10611
Affinity Capture-Western Homo sapiens
5 OBSL1 23363
Affinity Capture-MS Homo sapiens
6 MTNR1A  
Affinity Capture-Western Homo sapiens
7 CAMK2A 815
Reconstituted Complex Homo sapiens
8 GNB2 2783
Affinity Capture-Western Homo sapiens
9 MAP1B 4131
Affinity Capture-Western Homo sapiens
10 GNAO1 2775
Reconstituted Complex Homo sapiens
View the network image/svg+xml



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