Gene description for BTG1
Gene name B-cell translocation gene 1, anti-proliferative
Gene symbol BTG1
Other names/aliases -
Species Homo sapiens
 Database cross references - BTG1
ExoCarta ExoCarta_694
Vesiclepedia VP_694
Entrez Gene 694
HGNC 1130
MIM 109580
UniProt P62324  
 BTG1 identified in sEVs derived from the following tissue/cell type
Malignant pleural effusions 14975938    
Malignant pleural effusions 14975938    
 Gene ontology annotations for BTG1
Molecular Function
    transcription coregulator activity GO:0003712 NAS
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
    kinase binding GO:0019900 NAS
Biological Process
    regulation of DNA-templated transcription GO:0006355 NAS
    cell population proliferation GO:0008283 IEA
    negative regulation of cell population proliferation GO:0008285 IBA
    negative regulation of cell population proliferation GO:0008285 IDA
    negative regulation of cell population proliferation GO:0008285 IDA
    cell migration GO:0016477 NAS
    negative regulation of cell growth GO:0030308 NAS
    positive regulation of endothelial cell differentiation GO:0045603 IMP
    positive regulation of myoblast differentiation GO:0045663 IDA
    positive regulation of myoblast differentiation GO:0045663 NAS
    positive regulation of angiogenesis GO:0045766 IMP
    positive regulation of fibroblast apoptotic process GO:2000271 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IMP
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 IMP
 Experiment description of studies that identified BTG1 in sEVs
1
Experiment ID 51
MISEV standards
EM
Biophysical techniques
HSP90|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 14975938    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes isolated from human malignant pleural effusions.
Authors "Bard MP, Hegmans JP, Hemmes A, Luider TM, Willemsen R, Severijnen LA, van Meerbeeck JP, Burgers SA, Hoogsteden HC, Lambrecht BN"
Journal name AJRCMB
Publication year 2004
Sample Malignant pleural effusions
Sample name Pleural Fluid - Breast cancer
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
2
Experiment ID 52
MISEV standards
EM
Biophysical techniques
HSP90|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 14975938    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes isolated from human malignant pleural effusions.
Authors "Bard MP, Hegmans JP, Hemmes A, Luider TM, Willemsen R, Severijnen LA, van Meerbeeck JP, Burgers SA, Hoogsteden HC, Lambrecht BN"
Journal name AJRCMB
Publication year 2004
Sample Malignant pleural effusions
Sample name Pleural Fluid - Lung cancer
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for BTG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CNOT7 29883
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
2 FBXW7  
Affinity Capture-Western Homo sapiens
3 XRCC6 2547
Two-hybrid Homo sapiens
4 LIG4 3981
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
5 FBXL3  
Affinity Capture-Western Homo sapiens
6 TUBA1A 7846
Two-hybrid Homo sapiens
7 FBXW2  
Affinity Capture-Western Homo sapiens
8 HOXB9  
Two-hybrid Homo sapiens
Far Western Homo sapiens
9 CUL1 8454
Affinity Capture-Western Homo sapiens
10 BTRC 8945
Affinity Capture-Western Homo sapiens
11 FBXW11  
Affinity Capture-Western Homo sapiens
12 SKP2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
13 PRMT1 3276
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
14 CNOT8  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 GRB2 2885
Two-hybrid Homo sapiens
16 RNF181  
Two-hybrid Homo sapiens
17 SKP1 6500
Affinity Capture-Western Homo sapiens
18 FADD 8772
Two-hybrid Homo sapiens
19 FBXL5  
Affinity Capture-Western Homo sapiens
20 Cnot7  
Two-hybrid Mus musculus
Reconstituted Complex Mus musculus
View the network image/svg+xml



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