Gene description for Sdhb
Gene name succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Gene symbol Sdhb
Other names/aliases 0710008N11Rik
Species Mus musculus
 Database cross references - Sdhb
ExoCarta ExoCarta_67680
Entrez Gene 67680
UniProt Q9CQA3  
 Sdhb identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Sdhb
Molecular Function
    2 iron, 2 sulfur cluster binding GO:0051537 IEA
    3 iron, 4 sulfur cluster binding GO:0051538 IEA
    oxidoreductase activity GO:0016491 IEA
    iron-sulfur cluster binding GO:0051536 IEA
    succinate dehydrogenase (ubiquinone) activity GO:0008177 ISO
    electron carrier activity GO:0009055 IEA
    metal ion binding GO:0046872 IEA
    4 iron, 4 sulfur cluster binding GO:0051539 IEA
Biological Process
    respiratory electron transport chain GO:0022904 ISO
    succinate metabolic process GO:0006105 ISO
    tricarboxylic acid cycle GO:0006099 IEA
    transport GO:0006810 IEA
    oxidation-reduction process GO:0055114 IEA
Subcellular Localization
    mitochondrial inner membrane GO:0005743 ISO
    extracellular exosome GO:0070062 ISO
    respiratory chain complex II GO:0045273 IDA
    membrane GO:0016020 IEA
    mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 IDA
    mitochondrion GO:0005739 ISO
 Experiment description of studies that identified Sdhb in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Sdhb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sdhb is involved
PathwayEvidenceSource
Citric acid cycle (TCA cycle) IEA Reactome
Respiratory electron transport IEA Reactome





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