Gene description for Loxl4
Gene name lysyl oxidase-like 4
Gene symbol Loxl4
Other names/aliases 4833426I20Rik
Loxc
Species Mus musculus
 Database cross references - Loxl4
ExoCarta ExoCarta_67573
Vesiclepedia VP_67573
Entrez Gene 67573
UniProt Q924C6  
 Loxl4 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Loxl4
Molecular Function
    protein-lysine 6-oxidase activity GO:0004720 IBA
    protein-lysine 6-oxidase activity GO:0004720 IDA
    protein-lysine 6-oxidase activity GO:0004720 ISO
    copper ion binding GO:0005507 IEA
Biological Process
    collagen fibril organization GO:0030199 IBA
Subcellular Localization
    extracellular region GO:0005576 IDA
    extracellular region GO:0005576 ISS
    extracellular space GO:0005615 IBA
    membrane GO:0016020 IEA
    receptor complex GO:0043235 ISO
    collagen-containing extracellular matrix GO:0062023 IBA
 Experiment description of studies that identified Loxl4 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Loxl4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Col2a1 12824
Co-fractionation Mus musculus
2 Loxl2 94352
Co-fractionation Mus musculus
3 Mast1  
Co-fractionation Mus musculus
4 Loxl3  
Co-fractionation Mus musculus
View the network image/svg+xml



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