Gene description for KIF13A
Gene name kinesin family member 13A
Gene symbol KIF13A
Other names/aliases RBKIN
bA500C11.2
Species Homo sapiens
 Database cross references - KIF13A
ExoCarta ExoCarta_63971
Entrez Gene 63971
HGNC 14566
MIM 605433
UniProt Q9H1H9  
 KIF13A identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for KIF13A
Molecular Function
    ATPase activity GO:0016887 IBA
    ATP binding GO:0005524 IEA
    microtubule motor activity GO:0003777 ISS
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IEA
Biological Process
    melanosome organization GO:0032438 IMP
    Golgi to plasma membrane protein transport GO:0043001 ISS
    cytokinesis GO:0000910 IMP
    plus-end-directed vesicle transport along microtubule GO:0072383 ISS
    microtubule-based movement GO:0007018 IBA
    intracellular protein transport GO:0006886 IMP
    endosome to lysosome transport GO:0008333 IMP
    metabolic process GO:0008152 ISS
    cargo loading into vesicle GO:0035459 IMP
Subcellular Localization
    midbody GO:0030496 IDA
    trans-Golgi network membrane GO:0032588 ISS
    microtubule GO:0005874 IEA
    kinesin complex GO:0005871 IBA
    endosome membrane GO:0010008 IDA
    centrosome GO:0005813 IDA
 Experiment description of studies that identified KIF13A in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KIF13A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AP1B1 162
Invivo Homo sapiens
Invitro Homo sapiens
2 AP1G1 164
Invitro Homo sapiens
3 M6PR 4074
Invivo Homo sapiens
4 AP1M1 8907
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which KIF13A is involved
PathwayEvidenceSource
Association of TriC/CCT with target proteins during biosynthesis TAS Reactome





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