Gene description for CCL7
Gene name chemokine (C-C motif) ligand 7
Gene symbol CCL7
Other names/aliases FIC
MARC
MCP-3
MCP3
NC28
SCYA6
SCYA7
Species Homo sapiens
 Database cross references - CCL7
ExoCarta ExoCarta_6354
Entrez Gene 6354
HGNC 10634
MIM 158106
UniProt P80098  
 CCL7 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CCL7
Molecular Function
    chemokine activity GO:0008009 IDA
    heparin binding GO:0008201 IEA
    CCR2 chemokine receptor binding GO:0031727 IEA
    protein binding GO:0005515 IPI
    CCR1 chemokine receptor binding GO:0031726 IPI
Biological Process
    cell-cell signaling GO:0007267 TAS
    signal transduction GO:0007165 TAS
    immune response GO:0006955 IEA
    regulation of cell shape GO:0008360 IDA
    chemotaxis GO:0006935 TAS
    cytoskeleton organization GO:0007010 IDA
    positive regulation of natural killer cell chemotaxis GO:2000503 IDA
    monocyte chemotaxis GO:0002548 IC
    eosinophil chemotaxis GO:0048245 IDA
    cellular response to ethanol GO:0071361 IEA
    inflammatory response GO:0006954 IEA
    cellular calcium ion homeostasis GO:0006874 TAS
    positive regulation of cell migration GO:0030335 IDA
    response to gamma radiation GO:0010332 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IEA
    cell GO:0005623 TAS
 Experiment description of studies that identified CCL7 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CCL7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCBP2  
Invivo Homo sapiens
Invivo Homo sapiens
2 MMP2 4313
Invivo Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
3 FEZ1  
Two-hybrid Homo sapiens
4 CCR2  
Invitro Homo sapiens
5 CCR1  
Invivo Homo sapiens
Invitro Homo sapiens
6 CCR10  
Invivo Homo sapiens
7 CCR3  
Invitro Homo sapiens
8 CCL7 6354
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
View the network image/svg+xml
 Pathways in which CCL7 is involved
PathwayEvidenceSource
Chemokine receptors bind chemokines TAS Reactome





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