Gene description for RYR3
Gene name ryanodine receptor 3
Gene symbol RYR3
Other names/aliases RYR-3
Species Homo sapiens
 Database cross references - RYR3
ExoCarta ExoCarta_6263
Entrez Gene 6263
HGNC 10485
MIM 180903
UniProt Q15413  
 RYR3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for RYR3
Molecular Function
    calcium-release channel activity GO:0015278 IMP
    ryanodine-sensitive calcium-release channel activity GO:0005219 TAS
    calcium-induced calcium release activity GO:0048763 IEA
    calcium ion binding GO:0005509 IEA
    calmodulin binding GO:0005516 IEA
Biological Process
    transmembrane transport GO:0055085 TAS
    protein homotetramerization GO:0051289 ISS
    cellular response to magnesium ion GO:0071286 ISS
    negative regulation of cytosolic calcium ion concentration GO:0051481 IEA
    cellular response to calcium ion GO:0071277 ISS
    cellular response to caffeine GO:0071313 ISS
    ion transmembrane transport GO:0034220 TAS
    calcium ion transport GO:0006816 IMP
    calcium ion transmembrane transport GO:0070588 ISS
    striated muscle contraction GO:0006941 IEA
    cellular response to ATP GO:0071318 ISS
Subcellular Localization
    integral component of membrane GO:0016021 ISS
    perinuclear region of cytoplasm GO:0048471 IEA
    junctional membrane complex GO:0030314 IEA
    sarcoplasmic reticulum membrane GO:0033017 TAS
    cytosol GO:0005829 IEA
 Experiment description of studies that identified RYR3 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for RYR3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RYR2 6262
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 FKBP1A 2280
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which RYR3 is involved
Stimuli-sensing channels TAS Reactome

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