Gene description for TRPV4
Gene name	transient receptor potential cation channel, subfamily V, member 4
Gene symbol	TRPV4
Other names/aliases	BCYM3 CMT2C HMSN2C OTRPC4 SMAL SPSMA SSQTL1 TRP12 VRL2 VROAC
Species	Homo sapiens
Database cross references - TRPV4
ExoCarta	ExoCarta_59341
Vesiclepedia	VP_59341
Entrez Gene	59341
HGNC	18083
MIM	605427
UniProt	Q9HBA0
TRPV4 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for TRPV4

Molecular Function     actin binding GO:0003779 ISS     osmosensor activity GO:0005034 IEA     protein kinase C binding GO:0005080 ISS     monoatomic cation channel activity GO:0005261 IDA     calcium channel activity GO:0005262 IBA     calcium channel activity GO:0005262 IDA     calcium channel activity GO:0005262 TAS     protein binding GO:0005515 IPI     calmodulin binding GO:0005516 IMP     ATP binding GO:0005524 IEA     microtubule binding GO:0008017 ISS     lipid binding GO:0008289 IEA     stretch-activated, monoatomic cation-selective, calcium channel activity GO:0015275 IMP     protein kinase binding GO:0019901 IPI     SH2 domain binding GO:0042169 ISS     identical protein binding GO:0042802 IPI     alpha-tubulin binding GO:0043014 ISS     metal ion binding GO:0046872 IEA     beta-tubulin binding GO:0048487 ISS     actin filament binding GO:0051015 ISS Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IEA     response to hypoxia GO:0001666 IEA     diet induced thermogenesis GO:0002024 IEA     calcium ion transport GO:0006816 IDA     calcium ion transport GO:0006816 NAS     intracellular calcium ion homeostasis GO:0006874 IDA     cell volume homeostasis GO:0006884 TAS     actin filament organization GO:0007015 IBA     actin filament organization GO:0007015 ISS     cell-cell junction assembly GO:0007043 ISS     positive regulation of cytosolic calcium ion concentration GO:0007204 IDA     osmosensory signaling pathway GO:0007231 IBA     osmosensory signaling pathway GO:0007231 ISS     osmosensory signaling pathway GO:0007231 TAS     response to mechanical stimulus GO:0009612 TAS     positive regulation of macrophage chemotaxis GO:0010759 IEA     negative regulation of neuron projection development GO:0010977 ISS     actin cytoskeleton organization GO:0030036 ISS     vasopressin secretion GO:0030103 IEA     positive regulation of microtubule depolymerization GO:0031117 ISS     positive regulation of interleukin-6 production GO:0032755 IEA     response to insulin GO:0032868 IEA     cellular response to heat GO:0034605 ISS     hyperosmotic salinity response GO:0042538 IEA     glucose homeostasis GO:0042593 IEA     positive regulation of vascular permeability GO:0043117 IMP     cortical microtubule organization GO:0043622 ISS     positive regulation of striated muscle contraction GO:0045989 IEA     positive regulation of JNK cascade GO:0046330 IEA     microtubule polymerization GO:0046785 ISS     regulation of response to osmotic stress GO:0047484 IEA     positive regulation of inflammatory response GO:0050729 IEA     multicellular organismal-level water homeostasis GO:0050891 IMP     cartilage development involved in endochondral bone morphogenesis GO:0060351 IMP     positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA     calcium ion import GO:0070509 ISS     calcium ion transmembrane transport GO:0070588 IMP     calcium ion transmembrane transport GO:0070588 TAS     cellular response to osmotic stress GO:0071470 ISS     cellular hypotonic response GO:0071476 IMP     cellular hypotonic response GO:0071476 ISS     cellular hypotonic salinity response GO:0071477 IEA     positive regulation of monocyte chemotactic protein-1 production GO:0071639 IEA     positive regulation of macrophage inflammatory protein 1 alpha production GO:0071642 IEA     positive regulation of chemokine (C-C motif) ligand 5 production GO:0071651 IEA     blood vessel endothelial cell delamination GO:0097497 IMP     calcium ion import across plasma membrane GO:0098703 IBA     calcium ion import into cytosol GO:1902656 IDA     negative regulation of brown fat cell differentiation GO:1903444 IEA     regulation of aerobic respiration GO:1903715 IEA     positive regulation of chemokine (C-X-C motif) ligand 1 production GO:2000340 IEA Subcellular Localization     endoplasmic reticulum GO:0005783 IEA     cytoplasmic microtubule GO:0005881 ISS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISS     plasma membrane GO:0005886 TAS     adherens junction GO:0005912 ISS     focal adhesion GO:0005925 ISS     cilium GO:0005929 IBA     cell surface GO:0009986 IEA     membrane GO:0016020 NAS     apical plasma membrane GO:0016324 IEA     lamellipodium GO:0030027 ISS     filopodium GO:0030175 ISS     growth cone GO:0030426 ISS     cortical actin cytoskeleton GO:0030864 ISS     ruffle membrane GO:0032587 ISS