Gene description for TRPV4
Gene name transient receptor potential cation channel, subfamily V, member 4
Gene symbol TRPV4
Other names/aliases BCYM3
Species Homo sapiens
 Database cross references - TRPV4
ExoCarta ExoCarta_59341
Entrez Gene 59341
HGNC 18083
MIM 605427
UniProt Q9HBA0  
 TRPV4 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TRPV4
Molecular Function
    SH2 domain binding GO:0042169 ISS
    actin filament binding GO:0051015 ISS
    calmodulin binding GO:0005516 IMP
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    osmosensor activity GO:0005034 IEA
    beta-tubulin binding GO:0048487 ISS
    microtubule binding GO:0008017 ISS
    alpha-tubulin binding GO:0043014 ISS
    calcium channel activity GO:0005262 IDA
    protein kinase C binding GO:0005080 ISS
    cation channel activity GO:0005261 IDA
    protein kinase binding GO:0019901 IPI
    actin binding GO:0003779 ISS
Biological Process
    positive regulation of cytosolic calcium ion concentration GO:0007204 IDA
    vasopressin secretion GO:0030103 IEA
    cellular calcium ion homeostasis GO:0006874 IDA
    calcium ion transmembrane transport GO:0070588 TAS
    cortical microtubule organization GO:0043622 ISS
    cell-cell junction assembly GO:0007043 ISS
    response to mechanical stimulus GO:0009612 TAS
    cellular hypotonic response GO:0071476 ISS
    hyperosmotic salinity response GO:0042538 IEA
    transmembrane transport GO:0055085 TAS
    cellular response to heat GO:0034605 ISS
    negative regulation of neuron projection development GO:0010977 ISS
    cell volume homeostasis GO:0006884 TAS
    ion transmembrane transport GO:0034220 TAS
    microtubule polymerization GO:0046785 ISS
    calcium ion import GO:0070509 ISS
    calcium ion transport GO:0006816 NAS
    regulation of response to osmotic stress GO:0047484 IEA
    actin filament organization GO:0007015 ISS
    osmosensory signaling pathway GO:0007231 TAS
    positive regulation of microtubule depolymerization GO:0031117 ISS
    actin cytoskeleton reorganization GO:0031532 ISS
    cellular response to osmotic stress GO:0071470 ISS
Subcellular Localization
    adherens junction GO:0005912 ISS
    cytosol GO:0005829 IEA
    cytoplasmic microtubule GO:0005881 ISS
    growth cone GO:0030426 ISS
    plasma membrane GO:0005886 TAS
    filopodium GO:0030175 ISS
    cortical actin cytoskeleton GO:0030864 ISS
    cell surface GO:0009986 IEA
    ruffle membrane GO:0032587 ISS
    cytoplasmic vesicle GO:0031410 IEA
    integral component of membrane GO:0016021 NAS
    lamellipodium GO:0030027 ISS
    focal adhesion GO:0005925 ISS
    cilium GO:0005929 IEA
 Experiment description of studies that identified TRPV4 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TRPV4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YES1 7525
Invitro Homo sapiens
Invivo Homo sapiens
2 LYN 4067
Invivo Homo sapiens
Invitro Homo sapiens
3 SRC 6714
Invivo Homo sapiens
Invitro Homo sapiens
4 LCK 3932
Invitro Homo sapiens
Invivo Homo sapiens
5 FYN 2534
Invitro Homo sapiens
Invivo Homo sapiens
6 MAP7 9053
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
7 HCK 3055
Invitro Homo sapiens
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which TRPV4 is involved
TRP channels TAS Reactome

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