Gene description for ZBTB4
Gene name zinc finger and BTB domain containing 4
Gene symbol ZBTB4
Other names/aliases KAISO-L1
ZNF903
Species Homo sapiens
 Database cross references - ZBTB4
ExoCarta ExoCarta_57659
Vesiclepedia VP_57659
Entrez Gene 57659
HGNC 23847
MIM 612308
UniProt Q9P1Z0  
 ZBTB4 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for ZBTB4
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    protein binding GO:0005515 IPI
    methyl-CpG binding GO:0008327 IDA
    methyl-CpNpG binding GO:0010428 IDA
    protein kinase binding GO:0019901 IPI
    protein homodimerization activity GO:0042803 IDA
    sequence-specific DNA binding GO:0043565 IDA
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    regulation of DNA-templated transcription GO:0006355 IBA
    DNA damage response GO:0006974 IDA
    negative regulation of DNA-templated transcription GO:0045892 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    chromosome GO:0005694 IEA
    cytosol GO:0005829 IDA
    nuclear body GO:0016604 IDA
 Experiment description of studies that identified ZBTB4 in exosomes
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for ZBTB4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BANP  
Two-hybrid Homo sapiens
2 CCDC57 284001
Two-hybrid Homo sapiens
3 HIPK2 28996
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Co-localization Homo sapiens
4 PRDM5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CALCOCO2  
Two-hybrid Homo sapiens
6 ZBTB17  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
7 POU6F2  
Two-hybrid Homo sapiens
8 CEP76  
Two-hybrid Homo sapiens
9 KLHL12  
Two-hybrid Homo sapiens
10 CBFA2T3  
Two-hybrid Homo sapiens
11 CEP70  
Two-hybrid Homo sapiens
12 TRIM23 373
Two-hybrid Homo sapiens
13 CYSRT1 375791
Two-hybrid Homo sapiens
14 SIN3A  
Affinity Capture-Western Homo sapiens
15 PDE4DIP 9659
Two-hybrid Homo sapiens
16 S100B 6285
Affinity Capture-MS Homo sapiens
17 TP53BP2  
Two-hybrid Homo sapiens
18 SIN3B  
Affinity Capture-Western Homo sapiens
19 TP63  
Affinity Capture-MS Homo sapiens
20 GOLGA2 2801
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ZBTB4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here