Gene description for CTNNBIP1
Gene name catenin, beta interacting protein 1
Gene symbol CTNNBIP1
Other names/aliases ICAT
Species Homo sapiens
 Database cross references - CTNNBIP1
ExoCarta ExoCarta_56998
Entrez Gene 56998
HGNC 16913
MIM 607758
UniProt Q9NSA3  
 CTNNBIP1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for CTNNBIP1
Molecular Function
    protein binding GO:0005515 IPI
    armadillo repeat domain binding GO:0070016 IPI
    beta-catenin binding GO:0008013 IPI
Biological Process
    negative regulation of smooth muscle cell proliferation GO:0048662 IEA
    negative regulation of mesenchymal cell proliferation GO:0072201 IMP
    negative regulation of transcription initiation from RNA polymerase II promoter GO:0060633 IEA
    negative regulation of DNA binding GO:0043392 IEA
    negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 IMP
    anterior/posterior pattern specification GO:0009952 IBA
    negative regulation of Wnt signaling pathway GO:0030178 IBA
    positive regulation of monocyte differentiation GO:0045657 IMP
    positive regulation of osteoblast differentiation GO:0045669 IMP
    branching involved in ureteric bud morphogenesis GO:0001658 IBA
    negative regulation of protein binding GO:0032091 IDA
    regulation of vascular permeability involved in acute inflammatory response GO:0002528 IMP
    Wnt signaling pathway GO:0016055 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    beta-catenin destruction complex GO:0030877 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified CTNNBIP1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for CTNNBIP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CASP4  
Affinity Capture-MS Homo sapiens
2 RPA3  
Affinity Capture-MS Homo sapiens
3 CTNNB1 1499
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
4 CTSA 5476
Affinity Capture-MS Homo sapiens
5 CPVL  
Affinity Capture-MS Homo sapiens
6 GOT2 2806
Affinity Capture-MS Homo sapiens
7 FKSG17  
Affinity Capture-MS Homo sapiens
8 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
9 FLJ11588  
Two-hybrid Homo sapiens
10 JUP 3728
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 PNMA2  
Affinity Capture-MS Homo sapiens
12 GLB1 2720
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CTNNBIP1 is involved
PathwayEvidenceSource
deactivation of the beta-catenin transactivating complex TAS Reactome





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