Gene description for ATP7B
Gene name ATPase, Cu++ transporting, beta polypeptide
Gene symbol ATP7B
Other names/aliases PWD
WC1
WD
WND
Species Homo sapiens
 Database cross references - ATP7B
ExoCarta ExoCarta_540
Vesiclepedia VP_540
Entrez Gene 540
HGNC 870
MIM 606882
UniProt P35670  
 ATP7B identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ATP7B
Molecular Function
    copper ion transmembrane transporter activity GO:0005375 IDA
    copper ion binding GO:0005507 IBA
    copper ion binding GO:0005507 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IDA
    ATP hydrolysis activity GO:0016887 IEA
    P-type divalent copper transporter activity GO:0043682 IBA
    P-type divalent copper transporter activity GO:0043682 IMP
    P-type divalent copper transporter activity GO:0043682 NAS
    P-type divalent copper transporter activity GO:0043682 TAS
    P-type monovalent copper transporter activity GO:0140581 IEA
Biological Process
    copper ion transport GO:0006825 IDA
    copper ion transport GO:0006825 IGI
    copper ion transport GO:0006825 IMP
    intracellular copper ion homeostasis GO:0006878 IBA
    intracellular copper ion homeostasis GO:0006878 TAS
    intracellular zinc ion homeostasis GO:0006882 IEA
    lactation GO:0007595 IEA
    copper ion import GO:0015677 IBA
    copper ion import GO:0015677 IDA
    protein maturation by copper ion transfer GO:0015680 IEA
    monoatomic ion transmembrane transport GO:0034220 TAS
    response to copper ion GO:0046688 IDA
    sequestering of calcium ion GO:0051208 IDA
    establishment of localization in cell GO:0051649 IEA
    copper ion export GO:0060003 IBA
    viral translational frameshifting GO:0075523 IEA
    xenobiotic detoxification by transmembrane export across the plasma membrane GO:1990961 IC
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    mitochondrion GO:0005739 HTP
    late endosome GO:0005770 IDA
    Golgi apparatus GO:0005794 IDA
    trans-Golgi network GO:0005802 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 HDA
    basolateral plasma membrane GO:0016323 IDA
    cytoplasmic vesicle GO:0031410 IDA
    trans-Golgi network membrane GO:0032588 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified ATP7B in exosomes
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ATP7B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NRG1 3084
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 GRPR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 GJD3  
Proximity Label-MS Homo sapiens
4 TSPAN16  
Affinity Capture-MS Homo sapiens
5 C5AR1  
Affinity Capture-MS Homo sapiens
6 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
7 PCDHGB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TTYH1  
Affinity Capture-MS Homo sapiens
9 LAMTOR1 55004
Proximity Label-MS Homo sapiens
10 LAMP3  
Proximity Label-MS Homo sapiens
11 ATG9A 79065
Proximity Label-MS Homo sapiens
12 TMEM223  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TRIM66  
Affinity Capture-MS Homo sapiens
14 DNAJB2 3300
Affinity Capture-MS Homo sapiens
15 MANSC1 54682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CX3CL1  
Affinity Capture-MS Homo sapiens
17 LAMP2 3920
Proximity Label-MS Homo sapiens
18 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
19 FCER1A  
Affinity Capture-MS Homo sapiens
20 ZBTB16  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
21 CLU 1191
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
22 ITM2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 RAB4A 5867
Proximity Label-MS Homo sapiens
24 KCNE3  
Affinity Capture-MS Homo sapiens
25 HP 3240
Two-hybrid Homo sapiens
26 NTRK3 4916
Affinity Capture-MS Homo sapiens
27 KCNMB3  
Affinity Capture-MS Homo sapiens
28 RAB7A 7879
Proximity Label-MS Homo sapiens
29 DCTN4 51164
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
30 RAB9A 9367
Proximity Label-MS Homo sapiens
31 GOLGA1  
Proximity Label-MS Homo sapiens
32 GLRX 2745
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
33 CLEC2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 ATOX1 475
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
35 COMMD1 150684
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which ATP7B is involved
PathwayEvidenceSource
Ion channel transport TAS Reactome
Ion transport by P-type ATPases TAS Reactome
Transport of small molecules TAS Reactome





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