Gene description for ABHD17B
Gene name abhydrolase domain containing 17B
Gene symbol ABHD17B
Other names/aliases C9orf77
CGI-67
FAM108B1
Species Homo sapiens
 Database cross references - ABHD17B
ExoCarta ExoCarta_51104
Vesiclepedia VP_51104
Entrez Gene 51104
HGNC 24278
UniProt Q5VST6  
 ABHD17B identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ABHD17B
Molecular Function
    palmitoyl-(protein) hydrolase activity GO:0008474 IBA
    palmitoyl-(protein) hydrolase activity GO:0008474 IMP
Biological Process
    protein depalmitoylation GO:0002084 IGI
    protein depalmitoylation GO:0002084 IMP
    regulation of postsynapse organization GO:0099175 IBA
    regulation of protein localization to synapse GO:1902473 IEA
    negative regulation of protein localization to microtubule GO:1902817 IEA
    regulation of dendritic spine maintenance GO:1902950 IEA
    positive regulation of protein localization to endosome GO:1905668 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    endosome membrane GO:0010008 IBA
    membrane GO:0016020 HDA
    dendritic spine GO:0043197 IEA
    recycling endosome membrane GO:0055038 IEA
    postsynaptic density membrane GO:0098839 IEA
 Experiment description of studies that identified ABHD17B in sEVs
1
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ABHD17B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SV2C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 TACR3  
Affinity Capture-MS Homo sapiens
3 TRIM16L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SLC2A12 154091
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 DEFA1 1667
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 C5AR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 C5AR1  
Affinity Capture-MS Homo sapiens
8 NPTX1  
Affinity Capture-MS Homo sapiens
9 UPK2 7379
Affinity Capture-MS Homo sapiens
10 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 SLC22A8 9376
Affinity Capture-MS Homo sapiens
12 CXCR4 7852
Affinity Capture-MS Homo sapiens
13 PRG3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 MAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 TOR1AIP2 163590
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 MFSD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 LINC01565  
Affinity Capture-MS Homo sapiens
19 SFTA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 SLC26A6 65010
Affinity Capture-MS Homo sapiens
21 GPR12  
Affinity Capture-MS Homo sapiens
22 CD79B 974
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SLCO4C1 353189
Affinity Capture-MS Homo sapiens
24 SLC5A6 8884
Affinity Capture-MS Homo sapiens
25 LIPK  
Affinity Capture-MS Homo sapiens
26 AQP3  
Affinity Capture-MS Homo sapiens
27 OPRL1 4987
Affinity Capture-MS Homo sapiens
28 P2RY8  
Affinity Capture-MS Homo sapiens
29 FFAR1  
Affinity Capture-MS Homo sapiens
30 GPR150  
Affinity Capture-MS Homo sapiens
31 CD80 941
Affinity Capture-MS Homo sapiens
32 CRLF2 64109
Affinity Capture-MS Homo sapiens
33 SLC18A2  
Affinity Capture-MS Homo sapiens
34 LPCAT2 54947
Affinity Capture-MS Homo sapiens
35 NRBP1 29959
Affinity Capture-MS Homo sapiens
36 TCTEX1D2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 GPR17 2840
Affinity Capture-MS Homo sapiens
38 MICB  
Affinity Capture-MS Homo sapiens
39 GPR45  
Affinity Capture-MS Homo sapiens
40 SLC22A2 6582
Affinity Capture-MS Homo sapiens
41 GPR182  
Affinity Capture-MS Homo sapiens
42 FAM174A 345757
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 TCTEX1D4  
Affinity Capture-MS Homo sapiens
44 FAF2 23197
Affinity Capture-MS Homo sapiens
45 GXYLT1 283464
Affinity Capture-MS Homo sapiens
46 A4GALT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 OPRM1 4988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 GLMP 112770
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 EDN3  
Affinity Capture-MS Homo sapiens
50 GPR55  
Affinity Capture-MS Homo sapiens
51 CMTM8  
Affinity Capture-MS Homo sapiens
52 PRSS21  
Affinity Capture-MS Homo sapiens
53 SLC22A4 6583
Affinity Capture-MS Homo sapiens
54 BAI1  
Affinity Capture-MS Homo sapiens
55 SLC22A18 5002
Affinity Capture-MS Homo sapiens
56 TMEM192 201931
Affinity Capture-MS Homo sapiens
57 AVPR2  
Affinity Capture-MS Homo sapiens
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