Gene description for DDR2
Gene name	discoidin domain receptor tyrosine kinase 2
Gene symbol	DDR2
Other names/aliases	MIG20a NTRKR3 TKT TYRO10
Species	Homo sapiens
Database cross references - DDR2
ExoCarta	ExoCarta_4921
Entrez Gene	4921
HGNC	2731
MIM	191311
UniProt	Q16832
DDR2 identified in exosomes derived from the following tissue/cell type
Melanoma cells	25950383
Prostate cancer cells	25844599

Gene ontology annotations for DDR2

Molecular Function     protein tyrosine kinase collagen receptor activity GO:0038062 IDA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     collagen binding GO:0005518 IDA     transmembrane receptor protein tyrosine kinase activity GO:0004714 IDA Biological Process     collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IDA     peptidyl-tyrosine phosphorylation GO:0018108 IDA     biomineral tissue development GO:0031214 ISS     positive regulation of fibroblast proliferation GO:0048146 ISS     positive regulation of extracellular matrix disassembly GO:0090091 ISS     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IMP     endochondral bone growth GO:0003416 ISS     signal transduction GO:0007165 TAS     cell adhesion GO:0007155 TAS     positive regulation of fibroblast migration GO:0010763 TAS     protein autophosphorylation GO:0046777 IDA     extracellular matrix organization GO:0030198 TAS     positive regulation of osteoblast differentiation GO:0045669 IMP     collagen fibril organization GO:0030199 ISS     ossification GO:0001503 IEA     regulation of bone mineralization GO:0030500 IMP     regulation of extracellular matrix disassembly GO:0010715 TAS     chondrocyte proliferation GO:0035988 TAS     positive regulation of protein kinase activity GO:0045860 IMP Subcellular Localization     extracellular exosome GO:0070062 IDA     integral component of plasma membrane GO:0005887 IEA     plasma membrane GO:0005886 TAS     focal adhesion GO:0005925 IDA     apical plasma membrane GO:0016324 IEA