Gene description for NBL1
Gene name neuroblastoma 1, DAN family BMP antagonist
Gene symbol NBL1
Other names/aliases D1S1733E
Species Homo sapiens
 Database cross references - NBL1
ExoCarta ExoCarta_4681
Entrez Gene 4681
HGNC 7650
MIM 600613
UniProt P41271  
 NBL1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for NBL1
Molecular Function
    protein binding GO:0005515 IPI
    BMP binding GO:0036122 ISS
    morphogen activity GO:0016015 ISS
    protein homodimerization activity GO:0042803 IMP
Biological Process
    negative regulation of monocyte chemotaxis GO:0090027 ISS
    sequestering of BMP in extracellular matrix GO:0035582 ISS
    neuron projection morphogenesis GO:0048812 ISS
    positive regulation of neuron differentiation GO:0045666 ISS
    negative regulation of BMP signaling pathway GO:0030514 IDA
    nervous system development GO:0007399 ISS
    sequestering of BMP from receptor via BMP binding GO:0038098 IDA
    determination of dorsal identity GO:0048263 ISS
Subcellular Localization
    extracellular space GO:0005615 IC
 Experiment description of studies that identified NBL1 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for NBL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBQLN1 29979
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
2 BAG6 7917
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NBL1 is involved
No pathways found

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