Gene description for Tm1
Gene name Tropomyosin 1
Gene symbol Tm1
Other names/aliases 1305/10
2299
BcDNA:GH09289
BcDNA:LD37158
BcDNA:SD21996
CG4898
Dm Tm1
Dm TmH33
Dm TmH34
DmTm1
DmelCG4898
PmI
TM
TM1
TMII
Tm
TmH
TmH-33
TmH-34
TmH33
TmH34
TmII
Tmr33
Tmr34
TnH
TnH-33
TnH-34
cTM
cTm
cTmII
chr3R:11122272..11122408
l(3)02299
l(3)S130510
l(3)s2958
mTmII
region 3
tm1
tmII
tropomyosin
Species Drosophila melanogaster
 Database cross references - Tm1
ExoCarta ExoCarta_41852
Entrez Gene 41852
UniProt P06754   P49455  
 Tm1 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Tm1
Molecular Function
    actin filament binding GO:0051015 IDA
    actin binding GO:0003779 TAS
Biological Process
    dendrite morphogenesis GO:0048813 TAS
    pole plasm oskar mRNA localization GO:0045451 TAS
    muscle contraction GO:0006936 NAS
    oogenesis GO:0048477 TAS
    pole plasm assembly GO:0007315 NAS
    regulation of lamellipodium assembly GO:0010591 IMP
Subcellular Localization
    investment cone GO:0070865 IDA
    sarcoplasmic reticulum GO:0016529 IDA
    cytosol GO:0005829 IDA
    filamentous actin GO:0031941 IDA
    sarcomere GO:0030017 IDA
    muscle thin filament tropomyosin GO:0005862 NAS
 Experiment description of studies that identified Tm1 in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Tm1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tm1 is involved
No pathways found





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