Gene description for zip
Gene name zipper
Gene symbol zip
Other names/aliases CG15792
DROMHC
Dm nmII
DmelCG15792
DmnmII
Dronm-MII
E(br)
MHC
Mhc-c
Mhc-c[1]
Myo
Myo II
Myo-II
Myo-II HC
Myo2
MyoII
NMM
NMMII
ZIP
Zip
anon-WO0140519.37
l(2)02957
l(2)17F1
myo II
myoII
nmMHC
nmy-2
zip/MyoII
zpr
Species Drosophila melanogaster
 Database cross references - zip
ExoCarta ExoCarta_38001
Entrez Gene 38001
UniProt Q99323  
 zip identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for zip
Molecular Function
    ATPase activity, coupled GO:0042623 ISS
    ATP binding GO:0005524 IEA
    myosin light chain binding GO:0032027 IPI
    motor activity GO:0003774 ISS
Biological Process
    ovarian follicle cell migration GO:0007297 TAS
    muscle contraction GO:0006936 IMP
    myofibril assembly GO:0030239 IMP
    maintenance of protein location in cell GO:0032507 IMP
    establishment of planar polarity GO:0001736 NAS
    protein oligomerization GO:0051259 IDA
    dorsal closure, amnioserosa morphology change GO:0046664 IMP
    ecdysone-mediated induction of salivary gland cell autophagic cell death GO:0035072 NAS
    border follicle cell migration GO:0007298 IMP
    dorsal closure, leading edge cell differentiation GO:0046663 IMP
    muscle attachment GO:0016203 IGI
    regulation of cell cycle GO:0051726 IDA
    anterior midgut development GO:0007496 IMP
    sarcomere organization GO:0045214 IMP
    regulation of tube length, open tracheal system GO:0035159 IMP
    head involution GO:0008258 IMP
    myosin II filament assembly GO:0031036 IDA
    left/right axis specification GO:0070986 IMP
    imaginal disc-derived wing hair organization GO:0035317 IGI
    dorsal closure GO:0007391 TAS
    Malpighian tubule morphogenesis GO:0007443 IMP
    mitotic cytokinesis GO:0000281 IMP
    establishment of neuroblast polarity GO:0045200 TAS
    spiracle morphogenesis, open tracheal system GO:0035277 IDA
    wound healing GO:0042060 IMP
    neurogenesis GO:0022008 IMP
    dorsal closure, spreading of leading edge cells GO:0007395 IMP
    salivary gland morphogenesis GO:0007435 IMP
    cuticle pattern formation GO:0035017 IMP
Subcellular Localization
    cell cortex GO:0005938 IMP
    unconventional myosin complex GO:0016461 NAS
    Z disc GO:0030018 IDA
    contractile ring GO:0070938 IDA
    apical cortex GO:0045179 TAS
    myosin complex GO:0016459 ISS
    cell leading edge GO:0031252 IDA
    myosin II complex GO:0016460 IPI
    cytosol GO:0005829 IDA
    cytoskeleton GO:0005856 NAS
    cleavage furrow GO:0032154 IDA
 Experiment description of studies that identified zip in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for zip
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which zip is involved
No pathways found





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