Gene description for KHK
Gene name ketohexokinase (fructokinase)
Gene symbol KHK
Other names/aliases -
Species Homo sapiens
 Database cross references - KHK
ExoCarta ExoCarta_3795
Entrez Gene 3795
HGNC 6315
MIM 614058
UniProt P50053  
 KHK identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for KHK
Molecular Function
    protein binding GO:0005515 IPI
    fructokinase activity GO:0008865 IDA
    ATP binding GO:0005524 IEA
    ketohexokinase activity GO:0004454 IDA
Biological Process
    fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate GO:0061624 TAS
    small molecule metabolic process GO:0044281 TAS
    regulation of glycogen metabolic process GO:0070873 IEA
    carbohydrate metabolic process GO:0005975 TAS
    carbohydrate phosphorylation GO:0046835 TAS
    fructose metabolic process GO:0006000 TAS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified KHK in exosomes
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for KHK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SNRPB 6628
Affinity Capture-MS Homo sapiens
2 AP2S1 1175
Affinity Capture-MS Homo sapiens
3 ARRB1 408
Affinity Capture-MS Homo sapiens
4 LCN1 3933
Affinity Capture-MS Homo sapiens
5 CD2BP2 10421
Affinity Capture-MS Homo sapiens
6 RNPS1 10921
Affinity Capture-MS Homo sapiens
7 RANBP3 8498
Affinity Capture-MS Homo sapiens
8 DEDD  
Affinity Capture-MS Homo sapiens
9 LYZ 4069
Affinity Capture-MS Homo sapiens
10 CDK5RAP3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KHK is involved
Essential fructosuria TAS Reactome
Fructose catabolism TAS Reactome

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