Gene description for HMGCS2
Gene name 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
Gene symbol HMGCS2
Other names/aliases -
Species Homo sapiens
 Database cross references - HMGCS2
ExoCarta ExoCarta_3158
Entrez Gene 3158
HGNC 5008
MIM 600234
UniProt P54868  
 HMGCS2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for HMGCS2
Molecular Function
    hydroxymethylglutaryl-CoA synthase activity GO:0004421 IEA
Biological Process
    ketone body biosynthetic process GO:0046951 TAS
    cellular ketone body metabolic process GO:0046950 TAS
    isoprenoid biosynthetic process GO:0008299 IEA
    cellular lipid metabolic process GO:0044255 TAS
    cholesterol biosynthetic process GO:0006695 IEA
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    mitochondrion GO:0005739 TAS
    mitochondrial matrix GO:0005759 TAS
    mitochondrial inner membrane GO:0005743 IEA
 Experiment description of studies that identified HMGCS2 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for HMGCS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HMGCS2 is involved
PathwayEvidenceSource
PPARA activates gene expression TAS Reactome
Synthesis of Ketone Bodies TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here