Gene description for Usp25
Gene name ubiquitin specific peptidase 25
Gene symbol Usp25
Other names/aliases -
Species Mus musculus
 Database cross references - Usp25
ExoCarta ExoCarta_30940
Vesiclepedia VP_30940
Entrez Gene 30940
UniProt P57080  
 Usp25 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Usp25
Molecular Function
    cysteine-type deubiquitinase activity GO:0004843 IBA
    cysteine-type deubiquitinase activity GO:0004843 ISO
    cysteine-type deubiquitinase activity GO:0004843 ISS
    ubiquitin protein ligase binding GO:0031625 ISO
    SUMO binding GO:0032183 IBA
    SUMO binding GO:0032183 ISO
    ATPase binding GO:0051117 ISO
    deubiquitinase activity GO:0101005 ISO
Biological Process
    cytokine production GO:0001816 IMP
    ubiquitin-dependent protein catabolic process GO:0006511 ISS
    immune response GO:0006955 IMP
    response to oxidative stress GO:0006979 IMP
    I-kappaB phosphorylation GO:0007252 IMP
    mRNA metabolic process GO:0016071 IMP
    protein deubiquitination GO:0016579 IEA
    protein deubiquitination GO:0016579 ISO
    stress-activated protein kinase signaling cascade GO:0031098 IMP
    regulation of protein stability GO:0031647 IBA
    chemokine production GO:0032602 IMP
    protein K63-linked deubiquitination GO:0070536 ISO
    protein K48-linked deubiquitination GO:0071108 ISO
    interleukin-17-mediated signaling pathway GO:0097400 IDA
    interleukin-17-mediated signaling pathway GO:0097400 IMP
    negative regulation of response to oxidative stress GO:1902883 ISO
    negative regulation of interleukin-17-mediated signaling pathway GO:1903882 ISO
    negative regulation of ERAD pathway GO:1904293 ISO
Subcellular Localization
    proteasome complex GO:0000502 ISS
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
    endoplasmic reticulum GO:0005783 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Usp25 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Usp25
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Aldoa 11674
Affinity Capture-MS Mus musculus
2 Ubc  
Affinity Capture-MS Mus musculus
3 Arg1  
Affinity Capture-MS Mus musculus
4 Aspscr1  
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
5 Slc2a4  
Affinity Capture-Western Mus musculus
6 Hspa8 15481
Affinity Capture-MS Mus musculus
7 Pkm 18746
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
8 Keap1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
9 Cltc 67300
Affinity Capture-MS Mus musculus
10 Myh9 17886
Affinity Capture-MS Mus musculus
11 Actb 11461
Affinity Capture-MS Mus musculus
12 Eno1 13806
Affinity Capture-MS Mus musculus
13 Atp5b 11947
Affinity Capture-MS Mus musculus
14 Gapdh 14433
Affinity Capture-MS Mus musculus
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