Gene description for GZMA
Gene name granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
Gene symbol GZMA
Other names/aliases CTLA3
HFSP
Species Homo sapiens
 Database cross references - GZMA
ExoCarta ExoCarta_3001
Vesiclepedia VP_3001
Entrez Gene 3001
HGNC 4708
MIM 140050
UniProt P12544  
 GZMA identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for GZMA
Molecular Function
    serine-type endopeptidase activity GO:0004252 IBA
    serine-type endopeptidase activity GO:0004252 IDA
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IDA
Biological Process
    apoptotic process GO:0006915 TAS
    immune response GO:0006955 TAS
    response to bacterium GO:0009617 IEA
    killing of cells of another organism GO:0031640 IEA
    negative regulation of endodeoxyribonuclease activity GO:0032078 IDA
    positive regulation of apoptotic process GO:0043065 IDA
    negative regulation of DNA binding GO:0043392 IDA
    negative regulation of oxidoreductase activity GO:0051354 IDA
    proteolysis involved in protein catabolic process GO:0051603 IDA
    protein maturation GO:0051604 IBA
    protein maturation GO:0051604 IDA
    pyroptotic inflammatory response GO:0070269 IDA
    granzyme-mediated programmed cell death signaling pathway GO:0140507 IBA
    granzyme-mediated programmed cell death signaling pathway GO:0140507 IDA
    cytotoxic T cell pyroptotic cell death GO:1902483 IDA
Subcellular Localization
    immunological synapse GO:0001772 TAS
    extracellular space GO:0005615 IBA
    nucleus GO:0005634 TAS
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified GZMA in sEVs
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for GZMA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPK 3190
Biochemical Activity Homo sapiens
2 HSPA4 3308
Reconstituted Complex Homo sapiens
3 HIST1H1A 3024
Biochemical Activity Homo sapiens
4 XRCC6 2547
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
5 HIST2H2BE 8349
Biochemical Activity Homo sapiens
6 GOLGA2 2801
Biochemical Activity Homo sapiens
7 HDC  
Biochemical Activity Homo sapiens
8 HMGB2 3148
Reconstituted Complex Homo sapiens
9 NDUFS3 4722
Biochemical Activity Homo sapiens
10 LMNA 4000
Biochemical Activity Homo sapiens
11 ACTG1 71
Biochemical Activity Homo sapiens
12 SET 6418
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
13 HSP90AA1 3320
Reconstituted Complex Homo sapiens
14 XRCC5 7520
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
15 Ndufs3 68349
Biochemical Activity Mus musculus
16 GZMA 3001
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which GZMA is involved
No pathways found





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