Gene description for Rpl19
Gene name ribosomal protein L19
Gene symbol Rpl19
Other names/aliases -
Species Mus musculus
 Database cross references - Rpl19
ExoCarta ExoCarta_19921
Vesiclepedia VP_19921
Entrez Gene 19921
UniProt P84099  
 Rpl19 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Mast cells 17486113    
Pancreatic cells 19351151    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Rpl19
Molecular Function
    RNA binding GO:0003723 IBA
    RNA binding GO:0003723 IEA
    structural constituent of ribosome GO:0003735 IBA
    structural constituent of ribosome GO:0003735 IDA
    structural constituent of ribosome GO:0003735 ISO
    large ribosomal subunit rRNA binding GO:0070180 ISO
    5.8S rRNA binding GO:1990932 ISO
Biological Process
    cytoplasmic translation GO:0002181 ISO
    cytoplasmic translation GO:0002181 NAS
    translation GO:0006412 IC
Subcellular Localization
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 TAS
    cytosolic large ribosomal subunit GO:0022625 IBA
    cytosolic large ribosomal subunit GO:0022625 IDA
    cytosolic large ribosomal subunit GO:0022625 IPI
    cytosolic large ribosomal subunit GO:0022625 ISO
    cytosolic ribosome GO:0022626 ISO
    synapse GO:0045202 EXP
    synapse GO:0045202 IDA
 Experiment description of studies that identified Rpl19 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
3
Experiment ID 188
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|UCHL1|HSP90
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Rpl19
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rps3 27050
Co-fractionation Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Elf5  
Affinity Capture-MS Mus musculus
4 Rps18 20084
Co-fractionation Mus musculus
5 Rps25 75617
Co-fractionation Mus musculus
6 Nmt1  
Co-fractionation Mus musculus
7 Sars 20226
Co-fractionation Mus musculus
8 Impdh1  
Co-fractionation Mus musculus
9 Eif4a1 13681
Co-fractionation Mus musculus
10 Rps8 20116
Co-fractionation Mus musculus
11 Tubb1  
Co-fractionation Mus musculus
12 Rpl6 19988
Co-fractionation Mus musculus
13 Fzr1  
Affinity Capture-MS Mus musculus
14 Pkm 18746
Co-fractionation Mus musculus
15 Tpt1 22070
Co-fractionation Mus musculus
16 Eef1a2 13628
Co-fractionation Mus musculus
17 Rpl37 67281
Co-fractionation Mus musculus
18 Rps10 67097
Co-fractionation Mus musculus
19 Mettl21e  
Affinity Capture-MS Mus musculus
20 Tmem173  
Proximity Label-MS Mus musculus
21 Eif6 16418
Co-fractionation Mus musculus
22 Zbtb7b  
Affinity Capture-MS Mus musculus
23 Eef1a1 13627
Co-fractionation Mus musculus
24 Ran 19384
Co-fractionation Mus musculus
25 Rpl35 66489
Co-fractionation Mus musculus
26 Rps3a1 20091
Co-fractionation Mus musculus
27 Dhx15 13204
Co-fractionation Mus musculus
28 Fancd2  
Affinity Capture-MS Mus musculus
29 Rps14 20044
Co-fractionation Mus musculus
30 Setd3  
Co-fractionation Mus musculus
31 Rpl30 19946
Co-fractionation Mus musculus
32 Eed  
Affinity Capture-MS Mus musculus
33 Rpsa 16785
Co-fractionation Mus musculus
34 Eef1b2 55949
Co-fractionation Mus musculus
35 Rpl5 100503670
Co-fractionation Mus musculus
36 Rps20 67427
Co-fractionation Mus musculus
37 Rpl8 26961
Co-fractionation Mus musculus
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