Gene description for Prkca
Gene name	protein kinase C, alpha
Gene symbol	Prkca
Other names/aliases	AI875142 Pkca
Species	Mus musculus
Database cross references - Prkca
ExoCarta	ExoCarta_18750
Vesiclepedia	VP_18750
Entrez Gene	18750
UniProt	P20444
Prkca identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Prkca

Molecular Function     protein kinase activity GO:0004672 ISO     protein serine/threonine kinase activity GO:0004674 IBA     protein serine/threonine kinase activity GO:0004674 IDA     diacylglycerol-dependent serine/threonine kinase activity GO:0004697 IDA     diacylglycerol-dependent serine/threonine kinase activity GO:0004697 ISO     calcium,diacylglycerol-dependent serine/threonine kinase activity GO:0004698 IDA     calcium,diacylglycerol-dependent serine/threonine kinase activity GO:0004698 IMP     calcium,diacylglycerol-dependent serine/threonine kinase activity GO:0004698 ISO     diacylglycerol-dependent, calcium-independent serine/threonine kinase activity GO:0004699 IEA     integrin binding GO:0005178 IPI     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     zinc ion binding GO:0008270 IEA     lipid binding GO:0008289 EXP     enzyme binding GO:0019899 ISO     histone H3T6 kinase activity GO:0035403 ISO     protein serine kinase activity GO:0106310 IEA Biological Process     response to reactive oxygen species GO:0000302 ISO     angiogenesis GO:0001525 IEA     negative regulation of protein phosphorylation GO:0001933 IGI     negative regulation of protein phosphorylation GO:0001933 IMP     positive regulation of protein phosphorylation GO:0001934 IMP     positive regulation of endothelial cell proliferation GO:0001938 ISO     positive regulation of endothelial cell proliferation GO:0001938 ISS     regulation of the force of heart contraction GO:0002026 IMP     chondrocyte differentiation GO:0002062 IDA     desmosome assembly GO:0002159 ISO     protein phosphorylation GO:0006468 IDA     protein phosphorylation GO:0006468 IDA     protein phosphorylation GO:0006468 IGI     protein phosphorylation GO:0006468 IMP     protein phosphorylation GO:0006468 ISO     negative regulation of protein kinase activity GO:0006469 IMP     intracellular calcium ion homeostasis GO:0006874 IMP     regulation of muscle contraction GO:0006937 IMP     cell adhesion GO:0007155 IEA     learning or memory GO:0007611 ISO     cell population proliferation GO:0008283 IGI     negative regulation of cell population proliferation GO:0008285 IGI     positive regulation of endothelial cell migration GO:0010595 ISO     positive regulation of endothelial cell migration GO:0010595 ISS     positive regulation of cardiac muscle hypertrophy GO:0010613 ISO     positive regulation of cardiac muscle hypertrophy GO:0010613 ISS     negative regulation of translation GO:0017148 ISO     central nervous system neuron axonogenesis GO:0021955 ISO     positive regulation of cell migration GO:0030335 ISO     positive regulation of cell migration GO:0030335 ISS     neutrophil chemotaxis GO:0030593 IMP     positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 ISO     positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666 ISS     response to estradiol GO:0032355 ISO     negative regulation of glial cell apoptotic process GO:0034351 ISO     negative regulation of glial cell apoptotic process GO:0034351 ISS     intracellular signal transduction GO:0035556 IBA     intracellular signal transduction GO:0035556 ISO     peptidyl-serine autophosphorylation GO:0036289 IDA     negative regulation of MAPK cascade GO:0043409 IMP     positive regulation of blood vessel endothelial cell migration GO:0043536 ISO     post-translational protein modification GO:0043687 ISO     response to ethanol GO:0045471 ISO     positive regulation of macrophage differentiation GO:0045651 IMP     positive regulation of angiogenesis GO:0045766 ISO     positive regulation of angiogenesis GO:0045766 ISS     positive regulation of bone resorption GO:0045780 IMP     positive regulation of cell adhesion GO:0045785 ISO     positive regulation of cell adhesion GO:0045785 ISS     positive regulation of exocytosis GO:0045921 ISO     positive regulation of mitotic cell cycle GO:0045931 ISO     positive regulation of mitotic cell cycle GO:0045931 ISS     negative regulation of D-glucose import GO:0046325 IMP     negative regulation of insulin receptor signaling pathway GO:0046627 IMP     muscle cell cellular homeostasis GO:0046716 IMP     regulation of receptor-mediated endocytosis GO:0048259 ISO     positive regulation of smooth muscle cell proliferation GO:0048661 ISO     stem cell differentiation GO:0048863 IDA     positive regulation of inflammatory response GO:0050729 IMP     regulation of peptidyl-tyrosine phosphorylation GO:0050730 IMP     induction of positive chemotaxis GO:0050930 IMP     positive regulation of synapse assembly GO:0051965 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS     response to interleukin-1 GO:0070555 ISO     cellular response to carbohydrate stimulus GO:0071322 IDA     regulation of platelet aggregation GO:0090330 IMP     regulation of platelet aggregation GO:0090330 ISO     intrinsic apoptotic signaling pathway GO:0097193 IMP     presynaptic modulation of chemical synaptic transmission GO:0099171 IDA     presynaptic modulation of chemical synaptic transmission GO:0099171 IMP     positive regulation of angiotensin-activated signaling pathway GO:0110063 ISO     regulation of synaptic vesicle exocytosis GO:2000300 IDA     regulation of synaptic vesicle exocytosis GO:2000300 IMP     positive regulation of dense core granule biogenesis GO:2000707 IMP Subcellular Localization     nucleus GO:0005634 IDA     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 IDA     endoplasmic reticulum GO:0005783 ISO     cytosol GO:0005829 ISO     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     intercalated disc GO:0014704 IDA     membrane GO:0016020 IDA     axon GO:0030424 IDA     dendrite GO:0030425 IDA     mitochondrial membrane GO:0031966 IEA     protein-containing complex GO:0032991 IDA     protein-containing complex GO:0032991 ISO     alphav-beta3 integrin-PKCalpha complex GO:0035866 IDA     ciliary basal body GO:0036064 ISO     neuronal cell body GO:0043025 IDA     calyx of Held GO:0044305 IDA     calyx of Held GO:0044305 IMP     apical part of cell GO:0045177 IDA     perinuclear region of cytoplasm GO:0048471 ISO     perinuclear region of cytoplasm GO:0048471 ISS     presynaptic cytosol GO:0099523 IDA     cone photoreceptor outer segment GO:0120199 IDA     ooplasm GO:1990917 IDA