Gene description for DNTT
Gene name DNA nucleotidylexotransferase
Gene symbol DNTT
Other names/aliases TDT
Species Homo sapiens
 Database cross references - DNTT
ExoCarta ExoCarta_1791
Entrez Gene 1791
HGNC 2983
MIM 187410
UniProt P04053  
 DNTT identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for DNTT
Molecular Function
    DNA-directed DNA polymerase activity GO:0003887 IEA
    DNA nucleotidylexotransferase activity GO:0003912 IDA
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    DNA binding GO:0003677 IEA
Biological Process
    DNA modification GO:0006304 IEA
    DNA biosynthetic process GO:0071897 IEA
    DNA metabolic process GO:0006259 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified DNTT in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DNTT
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRPF19 27339
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
2 XRCC6 2547
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
3 PCNA 5111
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
4 ERBP  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which DNTT is involved
No pathways found

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