Gene description for COL3A1
Gene name collagen, type III, alpha 1
Gene symbol COL3A1
Other names/aliases EDS4A
Species Homo sapiens
 Database cross references - COL3A1
ExoCarta ExoCarta_1281
Entrez Gene 1281
HGNC 2201
MIM 120180
UniProt P02461  
 COL3A1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for COL3A1
Molecular Function
    platelet-derived growth factor binding GO:0048407 IDA
    integrin binding GO:0005178 NAS
    SMAD binding GO:0046332 IEA
    protein binding GO:0005515 IPI
    extracellular matrix structural constituent GO:0005201 IMP
    metal ion binding GO:0046872 IEA
Biological Process
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    digestive tract development GO:0048565 IEA
    response to cytokine GO:0034097 IDA
    positive regulation of Rho protein signal transduction GO:0035025 ISS
    integrin-mediated signaling pathway GO:0007229 IMP
    negative regulation of neuron migration GO:2001223 ISS
    aging GO:0007568 IEA
    heart development GO:0007507 IMP
    receptor-mediated endocytosis GO:0006898 TAS
    peptide cross-linking GO:0018149 IDA
    extracellular fibril organization GO:0043206 IMP
    skin development GO:0043588 IMP
    extracellular matrix organization GO:0030198 TAS
    collagen fibril organization GO:0030199 NAS
    cell-matrix adhesion GO:0007160 IDA
    negative regulation of immune response GO:0050777 IMP
    wound healing GO:0042060 NAS
    axon guidance GO:0007411 TAS
    cellular response to amino acid stimulus GO:0071230 IEA
    skeletal system development GO:0001501 IEA
    aorta smooth muscle tissue morphogenesis GO:0060414 IEA
    platelet activation GO:0030168 NAS
    response to mechanical stimulus GO:0009612 IEA
    response to radiation GO:0009314 IDA
    extracellular matrix disassembly GO:0022617 TAS
    collagen catabolic process GO:0030574 TAS
    cerebral cortex development GO:0021987 ISS
Subcellular Localization
    extracellular space GO:0005615 NAS
    endoplasmic reticulum lumen GO:0005788 TAS
    extracellular matrix GO:0031012 TAS
    extracellular region GO:0005576 TAS
    collagen type III trimer GO:0005586 NAS
 Experiment description of studies that identified COL3A1 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for COL3A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 THBS1 7057
Reconstituted Complex Homo sapiens
2 SPARC 6678
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
3 DDR2 4921
Invitro Homo sapiens
4 MAG  
Invitro Homo sapiens
5 FGF7  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
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