Gene description for LTB4R
Gene name leukotriene B4 receptor
Gene symbol LTB4R
Other names/aliases BLT1
BLTR
CMKRL1
GPR16
LTB4R1
LTBR1
P2RY7
P2Y7
Species Homo sapiens
 Database cross references - LTB4R
ExoCarta ExoCarta_1241
Vesiclepedia VP_1241
Entrez Gene 1241
HGNC 6713
MIM 601531
UniProt Q15722  
 LTB4R identified in sEVs derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for LTB4R
Molecular Function
    nucleotide binding GO:0000166 TAS
    leukotriene B4 receptor activity GO:0001632 IBA
    leukotriene receptor activity GO:0004974 TAS
    G protein-coupled peptide receptor activity GO:0008528 IBA
Biological Process
    muscle contraction GO:0006936 TAS
    inflammatory response GO:0006954 TAS
    immune response GO:0006955 TAS
    G protein-coupled receptor signaling pathway GO:0007186 TAS
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 TAS
    neuropeptide signaling pathway GO:0007218 IBA
    leukotriene signaling pathway GO:0061737 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified LTB4R in sEVs
1
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LTB4R
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CYBB 1536
Affinity Capture-Western Homo sapiens
2 GNAI2 2771
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
3 YWHAG 7532
Two-hybrid Homo sapiens
4 LTB4R 1241
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
FRET Homo sapiens
5 APEX1 328
Affinity Capture-RNA Homo sapiens
View the network image/svg+xml



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