Gene description for Ctnnd1
Gene name catenin (cadherin associated protein), delta 1
Gene symbol Ctnnd1
Other names/aliases AA409437
AU019353
Catns
Ctnnd
P120
mKIAA0384
Species Mus musculus
 Database cross references - Ctnnd1
ExoCarta ExoCarta_12388
Vesiclepedia VP_12388
Entrez Gene 12388
UniProt P30999  
 Ctnnd1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ctnnd1
Molecular Function
    signaling receptor binding GO:0005102 ISO
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 ISO
    protein kinase binding GO:0019901 ISO
    protein phosphatase binding GO:0019903 IPI
    protein domain specific binding GO:0019904 IPI
    cadherin binding GO:0045296 IBA
    cadherin binding GO:0045296 ISO
    cell adhesion molecule binding GO:0050839 ISO
    protein sequestering activity GO:0140311 ISO
    protein tyrosine kinase binding GO:1990782 ISO
Biological Process
    morphogenesis of a polarized epithelium GO:0001738 IMP
    kidney development GO:0001822 IMP
    cell adhesion GO:0007155 IMP
    salivary gland morphogenesis GO:0007435 IMP
    positive regulation of protein processing GO:0010954 IGI
    positive regulation of protein processing GO:0010954 IMP
    Wnt signaling pathway GO:0016055 IEA
    cell-cell adhesion mediated by cadherin GO:0044331 ISO
    protein stabilization GO:0050821 ISO
    epithelial cell differentiation involved in salivary gland development GO:0060690 IMP
    glomerulus morphogenesis GO:0072102 IMP
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISO
    cell-cell adhesion GO:0098609 IBA
    cell-cell adhesion GO:0098609 IMP
    regulation of postsynaptic membrane neurotransmitter receptor levels GO:0099072 ISO
    positive regulation of protein localization to cell-cell junction GO:0150107 IMP
    positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 IGI
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 IDA
    cell-cell junction GO:0005911 ISO
    adherens junction GO:0005912 IBA
    adherens junction GO:0005912 IDA
    zonula adherens GO:0005915 ISO
    bicellular tight junction GO:0005923 IDA
    cell surface GO:0009986 ISO
    membrane GO:0016020 IDA
    apicolateral plasma membrane GO:0016327 IDA
    catenin complex GO:0016342 ISO
    flotillin complex GO:0016600 IDA
    lamellipodium GO:0030027 IDA
    lamellipodium GO:0030027 ISO
    growth cone GO:0030426 ISO
    midbody GO:0030496 ISO
    midbody GO:0030496 ISS
    dendritic spine GO:0043197 ISO
    Schaffer collateral - CA1 synapse GO:0098685 ISO
    hippocampal mossy fiber to CA3 synapse GO:0098686 ISO
    presynaptic active zone cytoplasmic component GO:0098831 ISO
    glutamatergic synapse GO:0098978 ISO
    postsynaptic density, intracellular component GO:0099092 ISO
 Experiment description of studies that identified Ctnnd1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ctnnd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Zbtb33  
Affinity Capture-Western Mus musculus
2 Ubc  
Reconstituted Complex Mus musculus
3 Gsk3a  
Affinity Capture-Western Mus musculus
Biochemical Activity Mus musculus
Affinity Capture-Western Mus musculus
4 Akt1  
Biochemical Activity Mus musculus
5 Tnik  
Affinity Capture-MS Mus musculus
6 Frmd5  
Co-fractionation Mus musculus
7 Ctnnb1 12387
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
8 Cdh1 12550
Affinity Capture-Western Mus musculus
Co-localization Mus musculus
9 MTNR1B  
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
10 Dlgap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
11 Kctd13  
Affinity Capture-MS Mus musculus
12 Ctnna1 12385
Co-fractionation Mus musculus
13 Sstr3  
Proximity Label-MS Mus musculus
14 Ywhaz 22631
Affinity Capture-Western Mus musculus
15 Arvcf  
Co-fractionation Mus musculus
16 Inpp5d 16331
Affinity Capture-MS Mus musculus
17 Tmem173  
Proximity Label-MS Mus musculus
18 Grin2b  
Affinity Capture-Western Mus musculus
19 Ptprq  
Affinity Capture-Western Mus musculus
20 Plekha7  
Co-fractionation Mus musculus
21 Kif3b  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
22 Rhoa 11848
Affinity Capture-Western Mus musculus
23 Grin1  
Affinity Capture-Western Mus musculus
24 Elf5  
Affinity Capture-MS Mus musculus
25 Erbb2ip 59079
Co-fractionation Mus musculus
26 Cdh2 12558
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
Affinity Capture-Western Mus musculus
27 Kifap3  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
28 Eed  
Affinity Capture-MS Mus musculus
29 Ywhae 22627
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
30 Jup 16480
Co-fractionation Mus musculus
31 Gsk3b  
Affinity Capture-Western Mus musculus
Biochemical Activity Mus musculus
Affinity Capture-Western Mus musculus
32 Wwc2  
Co-fractionation Mus musculus
33 Fancd2  
Affinity Capture-MS Mus musculus
34 Rasgrf1  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
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