Gene description for SLC27A5
Gene name solute carrier family 27 (fatty acid transporter), member 5
Gene symbol SLC27A5
Other names/aliases ACSB
ACSVL6
BACS
BAL
FACVL3
FATP-5
FATP5
VLACSR
VLCS-H2
VLCSH2
Species Homo sapiens
 Database cross references - SLC27A5
ExoCarta ExoCarta_10998
Vesiclepedia VP_10998
Entrez Gene 10998
HGNC 10999
MIM 603314
UniProt Q9Y2P5  
 SLC27A5 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC27A5
Molecular Function
    long-chain fatty acid-CoA ligase activity GO:0004467 IBA
    long-chain fatty acid-CoA ligase activity GO:0004467 TAS
    long-chain fatty acid transmembrane transporter activity GO:0005324 IBA
    long-chain fatty acid transmembrane transporter activity GO:0005324 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    oxidoreductase activity GO:0016491 IEA
    very long-chain fatty acid-CoA ligase activity GO:0031957 IDA
    protein-containing complex binding GO:0044877 IEA
    cholate-CoA ligase activity GO:0047747 IDA
Biological Process
    very long-chain fatty acid metabolic process GO:0000038 IDA
    long-chain fatty acid metabolic process GO:0001676 IBA
    triglyceride mobilization GO:0006642 IEA
    bile acid biosynthetic process GO:0006699 IDA
    bile acid biosynthetic process GO:0006699 TAS
    bile acid metabolic process GO:0008206 IBA
    bile acid and bile salt transport GO:0015721 TAS
    long-chain fatty acid import across plasma membrane GO:0015911 IEA
    long-chain fatty acid import into cell GO:0044539 IBA
    ketone body biosynthetic process GO:0046951 IEA
    establishment of localization in cell GO:0051649 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IDA
    endoplasmic reticulum membrane GO:0005789 TAS
    plasma membrane GO:0005886 IBA
    basal plasma membrane GO:0009925 IEA
    protein-containing complex GO:0032991 IEA
 Experiment description of studies that identified SLC27A5 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC27A5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPD 3184
Two-hybrid Homo sapiens
2 SEC24B 10427
Affinity Capture-MS Homo sapiens
3 NUP35 129401
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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