Gene description for CDH13
Gene name cadherin 13
Gene symbol CDH13
Other names/aliases CDHH
P105
Species Homo sapiens
 Database cross references - CDH13
ExoCarta ExoCarta_1012
Entrez Gene 1012
HGNC 1753
MIM 601364
UniProt P55290  
 CDH13 identified in exosomes derived from the following tissue/cell type
Melanoma cells 25950383    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CDH13
Molecular Function
    adiponectin binding GO:0055100 ISS
    cadherin binding GO:0045296 IDA
    lipoprotein particle binding GO:0071813 IDA
    low-density lipoprotein particle binding GO:0030169 IDA
    calcium ion binding GO:0005509 IEA
    protein homodimerization activity GO:0042803 IEA
Biological Process
    cell junction assembly GO:0034329 TAS
    endothelial cell migration GO:0043542 IDA
    positive regulation of cell-matrix adhesion GO:0001954 IMP
    positive regulation of cell migration GO:0030335 IDA
    positive regulation of positive chemotaxis GO:0050927 IDA
    regulation of endocytosis GO:0030100 IMP
    adherens junction organization GO:0034332 TAS
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IDA
    localization within membrane GO:0051668 IMP
    lamellipodium assembly GO:0030032 IDA
    positive regulation of endothelial cell proliferation GO:0001938 IMP
    negative regulation of cell proliferation GO:0008285 IDA
    positive regulation of calcium-mediated signaling GO:0050850 IDA
    Rho protein signal transduction GO:0007266 IMP
    low-density lipoprotein particle mediated signaling GO:0055096 IDA
    negative regulation of cell adhesion GO:0007162 IDA
    keratinocyte proliferation GO:0043616 IDA
    cell-cell junction organization GO:0045216 TAS
    positive regulation of smooth muscle cell proliferation GO:0048661 IMP
    sprouting angiogenesis GO:0002040 IDA
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 IDA
    Rac protein signal transduction GO:0016601 IMP
    regulation of epidermal growth factor receptor signaling pathway GO:0042058 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
Subcellular Localization
    focal adhesion GO:0005925 IDA
    neuron projection GO:0043005 IDA
    plasma membrane GO:0005886 TAS
    caveola GO:0005901 IDA
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 IDA
    cytoplasm GO:0005737 IDA
    anchored component of membrane GO:0031225 IEA
    external side of plasma membrane GO:0009897 IEA
 Experiment description of studies that identified CDH13 in exosomes
1
Experiment ID 260
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
FLOT1|CD81
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CDH13
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CDH13 is involved
PathwayEvidenceSource
Adherens junctions interactions TAS Reactome





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