Gene description for CDH4
Gene name cadherin 4, type 1, R-cadherin (retinal)
Gene symbol CDH4
Other names/aliases CAD4
R-CAD
RCAD
Species Homo sapiens
 Database cross references - CDH4
ExoCarta ExoCarta_1002
Vesiclepedia VP_1002
Entrez Gene 1002
HGNC 1763
MIM 603006
UniProt P55283  
 CDH4 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for CDH4
Molecular Function
    calcium ion binding GO:0005509 IEA
    beta-catenin binding GO:0008013 IBA
    cadherin binding GO:0045296 IBA
Biological Process
    cell morphogenesis GO:0000902 IBA
    cell-cell junction assembly GO:0007043 IBA
    cell adhesion GO:0007155 TAS
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IEA
    axon guidance GO:0007411 IEA
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 IBA
    cell migration GO:0016477 IBA
    adherens junction organization GO:0034332 IBA
    cell-cell adhesion mediated by cadherin GO:0044331 IBA
    positive regulation of axon extension GO:0045773 IEA
    axon extension GO:0048675 IEA
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    adherens junction GO:0005912 IBA
    catenin complex GO:0016342 IBA
 Experiment description of studies that identified CDH4 in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CDH4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDH2 1000
Affinity Capture-Western Homo sapiens
2 UBE2I 7329
Biochemical Activity Homo sapiens
3 CTNNA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 MKRN2 23609
Affinity Capture-RNA Homo sapiens
5 CDK5RAP3 80279
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
6 FUS 2521
Affinity Capture-MS Homo sapiens
7 MTNR1B  
Two-hybrid Homo sapiens
View the network image/svg+xml



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