Gene description for CD4
Gene name	CD4 molecule
Gene symbol	CD4
Other names/aliases	CD4mut
Species	Homo sapiens
Database cross references - CD4
ExoCarta	ExoCarta_920
Vesiclepedia	VP_920
Entrez Gene	920
HGNC	1678
MIM	186940
UniProt	P01730
CD4 identified in sEVs derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for CD4

Molecular Function     virus receptor activity GO:0001618 IEA     transmembrane signaling receptor activity GO:0004888 TAS     extracellular matrix structural constituent GO:0005201 NAS     protein binding GO:0005515 IPI     zinc ion binding GO:0008270 IDA     lipid binding GO:0008289 EXP     coreceptor activity GO:0015026 NAS     enzyme binding GO:0019899 IPI     protein kinase binding GO:0019901 IPI     MHC class II protein complex binding GO:0023026 IDA     signaling receptor activity GO:0038023 TAS     interleukin-16 binding GO:0042011 IPI     interleukin-16 receptor activity GO:0042012 IDA     MHC class II protein binding GO:0042289 IDA     MHC class II protein binding GO:0042289 IPI     MHC class II protein binding GO:0042289 NAS     identical protein binding GO:0042802 IPI     protein homodimerization activity GO:0042803 IDA     protein tyrosine kinase binding GO:1990782 IPI Biological Process     positive regulation of protein phosphorylation GO:0001934 IDA     adaptive immune response GO:0002250 IEA     immune response GO:0006955 NAS     cell adhesion GO:0007155 IEA     signal transduction GO:0007165 TAS     cell surface receptor signaling pathway GO:0007166 TAS     enzyme-linked receptor protein signaling pathway GO:0007167 TAS     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 NAS     calcium-mediated signaling GO:0019722 IEA     T cell differentiation GO:0030217 IDA     macrophage differentiation GO:0030225 IMP     maintenance of protein location in cell GO:0032507 IDA     positive regulation of interleukin-2 production GO:0032743 NAS     positive regulation of kinase activity GO:0033674 IDA     helper T cell enhancement of adaptive immune response GO:0035397 IEA     interleukin-15-mediated signaling pathway GO:0035723 IDA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA     positive regulation of MAPK cascade GO:0043410 IDA     T cell selection GO:0045058 IDA     positive regulation of monocyte differentiation GO:0045657 IDA     positive regulation of protein kinase activity GO:0045860 IDA     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of viral entry into host cell GO:0046598 IDA     symbiont entry into host cell GO:0046718 IEA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA     defense response to Gram-negative bacterium GO:0050829 IEA     positive regulation of calcium-mediated signaling GO:0050850 IEA     regulation of T cell activation GO:0050863 IDA     positive regulation of T cell activation GO:0050870 IEA     regulation of calcium ion transport GO:0051924 IDA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA     cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 IDA Subcellular Localization     early endosome GO:0005769 TAS     endoplasmic reticulum lumen GO:0005788 IEA     endoplasmic reticulum membrane GO:0005789 TAS     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     external side of plasma membrane GO:0009897 IDA     clathrin-coated endocytic vesicle membrane GO:0030669 TAS     T cell receptor complex GO:0042101 NAS     membrane raft GO:0045121 IDA