Gene description for PHB
Gene name prohibitin
Gene symbol PHB
Other names/aliases HEL-215
HEL-S-54e
PHB1
Species Homo sapiens
 Database cross references - PHB
ExoCarta ExoCarta_5245
Vesiclepedia VP_5245
Entrez Gene 5245
HGNC 8912
MIM 176705
UniProt P35232  
 PHB identified in sEVs derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 19415654    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Colorectal cancer cells 17956143    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Neuroblastoma cells 25944692    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Squamous carcinoma cells 20124223    
T lymphocytes 34108659    
 Gene ontology annotations for PHB
Molecular Function
    complement component C3a binding GO:0001850 IDA
    complement component C3b binding GO:0001851 IDA
    transcription corepressor activity GO:0003714 IDA
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
    proteinase activated receptor binding GO:0031871 IPI
    histone deacetylase binding GO:0042826 IPI
    protein heterodimerization activity GO:0046982 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    osteoblast differentiation GO:0001649 HDA
    positive regulation of immunoglobulin production GO:0002639 ISS
    regulation of DNA-templated transcription GO:0006355 IDA
    mitochondrion organization GO:0007005 IBA
    mitochondrion organization GO:0007005 IMP
    mitochondrion organization GO:0007005 NAS
    signal transduction GO:0007165 TAS
    negative regulation of cell population proliferation GO:0008285 IMP
    positive regulation of gene expression GO:0010628 IGI
    negative regulation of transcription by competitive promoter binding GO:0010944 IDA
    negative regulation of cell growth GO:0030308 IMP
    positive regulation of interleukin-17 production GO:0032740 IMP
    RIG-I signaling pathway GO:0039529 IDA
    epigenetic regulation of gene expression GO:0040029 IDA
    B cell activation GO:0042113 ISS
    negative regulation of protein catabolic process GO:0042177 IMP
    regulation of apoptotic process GO:0042981 TAS
    positive regulation of neuron apoptotic process GO:0043525 IGI
    modulation by host of viral RNA genome replication GO:0044830 ISS
    positive regulation of G protein-coupled receptor signaling pathway GO:0045745 IMP
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 IMP
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of complement activation GO:0045917 IDA
    symbiont entry into host cell GO:0046718 ISS
    positive regulation of smooth muscle cell proliferation GO:0048661 ISS
    protein stabilization GO:0050821 IDA
    protein stabilization GO:0050821 IMP
    progesterone receptor signaling pathway GO:0050847 IDA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS
    negative regulation of androgen receptor signaling pathway GO:0060766 IDA
    negative regulation of androgen receptor signaling pathway GO:0060766 IMP
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IMP
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP
    cellular response to interleukin-6 GO:0071354 IDA
    DNA biosynthetic process GO:0071897 IEA
    T-helper 17 type immune response GO:0072538 IDA
    antiviral innate immune response GO:0140374 IDA
    positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 ISS
    negative regulation of glucocorticoid receptor signaling pathway GO:2000323 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 TAS
    early endosome GO:0005769 IDA
    plasma membrane GO:0005886 IDA
    cell surface GO:0009986 IDA
    membrane GO:0016020 HDA
    mitochondrial prohibitin complex GO:0035632 IDA
    mitochondrial prohibitin complex GO:0035632 IPI
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified PHB in sEVs
1
Experiment ID 79
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 65
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19415654    
Organism Homo sapiens
Experiment description Proteomics of MUC1-containing lipid rafts from plasma membranes and exosomes of human breast carcinoma cells MCF-7.
Authors "Staubach S, Razawi H, Hanisch FG."
Journal name PROTEOMICS
Publication year 2009
Sample Breast cancer cells
Sample name MCF-7
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
8
Experiment ID 412
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
9
Experiment ID 414
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
10
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 20
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors "Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS"
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
13
Experiment ID 407
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
14
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
18
Experiment ID 405
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
19
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 235
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
23
Experiment ID 237
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
24
Experiment ID 417
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
25
Experiment ID 411
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
27
Experiment ID 418
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
28
Experiment ID 418
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
29
Experiment ID 224
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
30
Experiment ID 413
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
31
Experiment ID 211
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
32
Experiment ID 212
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
33
Experiment ID 406
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
34
Experiment ID 415
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
35
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
36
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
37
Experiment ID 408
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
38
Experiment ID 409
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
39
Experiment ID 416
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
40
Experiment ID 834
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
41
Experiment ID 835
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
42
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
43
Experiment ID 410
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for PHB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 PDHA1 5160
Co-fractionation Homo sapiens
3 ATP6V1B2 526
Co-fractionation Homo sapiens
4 P4HB 5034
Co-fractionation Homo sapiens
5 AFG3L2 10939
Co-fractionation Homo sapiens
6 Tmed2 56334
Affinity Capture-MS Mus musculus
7 KLF8  
Affinity Capture-MS Homo sapiens
8 POR 5447
Co-fractionation Homo sapiens
9 SPRTN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 UBL4A 8266
Affinity Capture-MS Homo sapiens
11 COL6A1 1291
Cross-Linking-MS (XL-MS) Homo sapiens
12 RAB1A 5861
Co-fractionation Homo sapiens
13 Mtx2  
Affinity Capture-MS Mus musculus
14 RPA2 6118
Proximity Label-MS Homo sapiens
15 VAPA 9218
Affinity Capture-MS Homo sapiens
16 MARCKS 4082
Proximity Label-MS Homo sapiens
17 COX15 1355
Proximity Label-MS Homo sapiens
18 RIN3  
Affinity Capture-MS Homo sapiens
19 RIT1 6016
Negative Genetic Homo sapiens
20 YWHAE 7531
Affinity Capture-MS Homo sapiens
21 CD4 920
Affinity Capture-MS Homo sapiens
22 E2F1 1869
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
23 TRUB2  
Proximity Label-MS Homo sapiens
24 ACTC1 70
Affinity Capture-MS Homo sapiens
25 MTG2  
Proximity Label-MS Homo sapiens
26 Atp2a2 11938
Affinity Capture-MS Mus musculus
27 APOE 348
Co-fractionation Homo sapiens
28 UQCRB 7381
Co-fractionation Homo sapiens
29 UBC 7316
Affinity Capture-MS Homo sapiens
30 NDUFS7 374291
Co-fractionation Homo sapiens
31 GOSR2 9570
Co-fractionation Homo sapiens
32 ACTN1 87
Affinity Capture-Western Homo sapiens
33 SEC22A  
Two-hybrid Homo sapiens
34 PTPN1 5770
Affinity Capture-MS Homo sapiens
35 SCCPDH 51097
Co-fractionation Homo sapiens
36 HSD17B12 51144
Co-fractionation Homo sapiens
37 Tmem109  
Affinity Capture-MS Mus musculus
38 CCDC90B  
Proximity Label-MS Homo sapiens
39 MYOD1  
Affinity Capture-MS Homo sapiens
40 ATP5L 10632
Co-fractionation Homo sapiens
41 ARMC7  
Affinity Capture-MS Homo sapiens
42 KIAA1429 25962
Affinity Capture-MS Homo sapiens
43 KIF20A 10112
Affinity Capture-MS Homo sapiens
44 NNT 23530
Co-fractionation Homo sapiens
45 NDUFB9 4715
Co-fractionation Homo sapiens
46 MGST1 4257
Co-fractionation Homo sapiens
47 NCOR1  
Affinity Capture-Western Homo sapiens
48 Eef1a1 13627
Affinity Capture-MS Mus musculus
49 NDUFS3 4722
Co-fractionation Homo sapiens
50 OGDH 4967
Co-fractionation Homo sapiens
51 PRC1 9055
Affinity Capture-MS Homo sapiens
52 PMPCA 23203
Proximity Label-MS Homo sapiens
53 HSPA5 3309
Co-fractionation Homo sapiens
54 GJB3  
Affinity Capture-MS Homo sapiens
55 COX7A2L 9167
Co-fractionation Homo sapiens
56 LONRF3  
Reconstituted Complex Homo sapiens
57 CYB5R1 51706
Co-fractionation Homo sapiens
58 RCN2 5955
Co-fractionation Homo sapiens
59 AI837181  
Affinity Capture-MS Mus musculus
60 NDUFA5 4698
Co-fractionation Homo sapiens
61 COA3 28958
Co-fractionation Homo sapiens
62 YIPF3 25844
Affinity Capture-MS Homo sapiens
63 DDRGK1 65992
Affinity Capture-MS Homo sapiens
64 SSR1 6745
Co-fractionation Homo sapiens
65 OBSL1 23363
Affinity Capture-MS Homo sapiens
66 C1qbp 12261
Affinity Capture-MS Mus musculus
67 DDOST 1650
Co-fractionation Homo sapiens
68 SLC25A12 8604
Proximity Label-MS Homo sapiens
69 SURF1  
Proximity Label-MS Homo sapiens
70 HSP90B1 7184
Co-fractionation Homo sapiens
71 ATP5O 539
Co-fractionation Homo sapiens
72 ATP5C1 509
Co-fractionation Homo sapiens
73 XIAP  
Affinity Capture-MS Homo sapiens
74 FANCD2  
Affinity Capture-MS Homo sapiens
75 C20orf24  
Co-fractionation Homo sapiens
76 ITGA4 3676
Affinity Capture-MS Homo sapiens
77 EED  
Affinity Capture-MS Homo sapiens
78 AIFM1 9131
Proximity Label-MS Homo sapiens
79 NDUFV1 4723
Co-fractionation Homo sapiens
80 VCAM1 7412
Affinity Capture-MS Homo sapiens
81 TOMM40 10452
Co-fractionation Homo sapiens
82 CD14 929
Affinity Capture-Western Homo sapiens
83 CANX 821
Co-fractionation Homo sapiens
84 ATP5H 10476
Co-fractionation Homo sapiens
85 TOMM5  
Co-fractionation Homo sapiens
86 SMAD5 4090
Proximity Label-MS Homo sapiens
87 TFCP2 7024
Affinity Capture-MS Homo sapiens
88 ANKRD34C  
Co-fractionation Homo sapiens
89 TACO1  
Proximity Label-MS Homo sapiens
90 KLF15  
Affinity Capture-MS Homo sapiens
91 NDUFA6  
Co-fractionation Homo sapiens
92 SMARCA2 6595
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
93 UQCRQ 27089
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
94 RIC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 NDUFS5 4725
Co-fractionation Homo sapiens
96 Lima1  
Affinity Capture-MS Mus musculus
97 ICAM1 3383
Co-fractionation Homo sapiens
98 KIF14 9928
Affinity Capture-MS Homo sapiens
99 ESR1  
Reconstituted Complex Homo sapiens
100 TMEM63B 55362
Affinity Capture-MS Homo sapiens
101 RAB1B 81876
Co-fractionation Homo sapiens
102 LMAN1 3998
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
103 MDH2 4191
Proximity Label-MS Homo sapiens
104 NUP155 9631
Proximity Label-MS Homo sapiens
105 STOML2 30968
Co-fractionation Homo sapiens
106 RB1 5925
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
107 APOO 79135
Proximity Label-MS Homo sapiens
108 SOX6  
Affinity Capture-MS Homo sapiens
109 NF2 4771
Affinity Capture-MS Homo sapiens
110 KLF5  
Affinity Capture-MS Homo sapiens
111 ZBTB2 57621
Affinity Capture-MS Homo sapiens
112 MTCH2 23788
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
113 C6orf203  
Proximity Label-MS Homo sapiens
114 ALDH16A1 126133
Co-fractionation Homo sapiens
115 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
116 TRIM26 7726
Affinity Capture-MS Homo sapiens
117 FASTKD5  
Proximity Label-MS Homo sapiens
118 PEX3 8504
Proximity Label-MS Homo sapiens
119 SNRPG 6637
Cross-Linking-MS (XL-MS) Homo sapiens
120 PARK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 STOM 2040
Affinity Capture-MS Homo sapiens
122 FOLR1 2348
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
123 LY6E  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
124 BRE 9577
Affinity Capture-MS Homo sapiens
125 NDUFA8 4702
Co-fractionation Homo sapiens
126 HADHA 3030
Co-fractionation Homo sapiens
127 STAU1 6780
Affinity Capture-MS Homo sapiens
128 PAM16  
Co-fractionation Homo sapiens
129 ATF2  
Affinity Capture-MS Homo sapiens
130 TPD52 7163
Co-fractionation Homo sapiens
131 DIABLO 56616
Proximity Label-MS Homo sapiens
132 SMARCA4 6597
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
133 ESRRB  
Affinity Capture-MS Homo sapiens
134 PLD3 23646
Affinity Capture-MS Homo sapiens
135 CYB5A 1528
Co-fractionation Homo sapiens
136 YAP1 10413
Affinity Capture-MS Homo sapiens
137 DIRAS3  
Proximity Label-MS Homo sapiens
138 VCP 7415
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
139 NTRK1 4914
Affinity Capture-MS Homo sapiens
140 SCAMP2 10066
Co-fractionation Homo sapiens
141 HMOX2 3163
Co-fractionation Homo sapiens
142 IFI16 3428
Affinity Capture-MS Homo sapiens
143 U2AF2 11338
Affinity Capture-MS Homo sapiens
144 LHX8  
Proximity Label-MS Homo sapiens
145 SYNCRIP 10492
Co-fractionation Homo sapiens
146 GFM1 85476
Proximity Label-MS Homo sapiens
147 HUWE1 10075
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 CYC1 1537
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
149 ADRB2  
Affinity Capture-MS Homo sapiens
150 RPN1 6184
Proximity Label-MS Homo sapiens
151 MRPL11 65003
Proximity Label-MS Homo sapiens
152 UQCRH 7388
Co-fractionation Homo sapiens
153 AGPS 8540
Co-fractionation Homo sapiens
154 PMAIP1  
Affinity Capture-MS Homo sapiens
155 HDAC5 10014
Affinity Capture-MS Homo sapiens
156 VDAC2 7417
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
157 NIPSNAP1 8508
Co-fractionation Homo sapiens
158 SEC61B 10952
Co-fractionation Homo sapiens
159 ATP5B 506
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
160 BCAP29 55973
Co-fractionation Homo sapiens
161 CD274 29126
Affinity Capture-MS Homo sapiens
162 CHCHD1  
Proximity Label-MS Homo sapiens
163 COX4I1 1327
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
164 RBL1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
165 ANLN 54443
Affinity Capture-MS Homo sapiens
166 ATG16L1 55054
Affinity Capture-MS Homo sapiens
167 Rab5c 19345
Affinity Capture-MS Mus musculus
168 TMPO 7112
Affinity Capture-MS Homo sapiens
169 OLA1 29789
Co-fractionation Homo sapiens
170 PSMA3 5684
Affinity Capture-MS Homo sapiens
171 COX5B 1329
Co-fractionation Homo sapiens
172 CLN3 1201
Affinity Capture-MS Homo sapiens
173 ZNF782  
Co-fractionation Homo sapiens
174 HADHB 3032
Co-fractionation Homo sapiens
175 MRRF  
Proximity Label-MS Homo sapiens
176 VAPB 9217
Co-fractionation Homo sapiens
177 SKP2  
Affinity Capture-Western Homo sapiens
178 METTL14  
Affinity Capture-MS Homo sapiens
179 TRIM31  
Affinity Capture-MS Homo sapiens
180 ATL3 25923
Co-fractionation Homo sapiens
181 NDUFB10 4716
Co-fractionation Homo sapiens
182 XPO1 7514
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
183 NDUFA9 4704
Co-fractionation Homo sapiens
184 PCCB 5096
Co-fractionation Homo sapiens
185 ECT2 1894
Affinity Capture-MS Homo sapiens
186 SLC25A51  
Proximity Label-MS Homo sapiens
187 EPAS1  
Affinity Capture-MS Homo sapiens
188 UQCRC2 7385
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
189 TRAF3IP1 26146
Affinity Capture-MS Homo sapiens
190 EEF2 1938
Co-fractionation Homo sapiens
191 Bmpr1a  
Affinity Capture-MS Mus musculus
192 CCDC109B 55013
Proximity Label-MS Homo sapiens
193 GOLT1B 51026
Affinity Capture-MS Homo sapiens
194 Rmdn3  
Affinity Capture-MS Mus musculus
195 BCAP31 10134
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
196 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
197 COX7A2 1347
Co-fractionation Homo sapiens
198 TOMM22 56993
Co-fractionation Homo sapiens
199 RMND1 55005
Proximity Label-MS Homo sapiens
200 PTPLA  
Affinity Capture-MS Homo sapiens
201 HSD17B10 3028
Co-fractionation Homo sapiens
202 COIL  
Proximity Label-MS Homo sapiens
203 FBXO6 26270
Affinity Capture-MS Homo sapiens
204 FUS 2521
Affinity Capture-MS Homo sapiens
205 YIPF5 81555
Affinity Capture-MS Homo sapiens
206 MYC  
Proximity Label-MS Homo sapiens
207 CORO1C 23603
Co-fractionation Homo sapiens
208 SUZ12  
Affinity Capture-MS Homo sapiens
209 FN1 2335
Affinity Capture-MS Homo sapiens
210 C17orf80 55028
Proximity Label-MS Homo sapiens
211 MTX2 10651
Affinity Capture-MS Homo sapiens
212 SLC25A24 29957
Co-fractionation Homo sapiens
213 CDK2 1017
Affinity Capture-MS Homo sapiens
214 RPA3 6119
Proximity Label-MS Homo sapiens
215 Rab11a 53869
Affinity Capture-MS Mus musculus
216 SSR3 6747
Co-fractionation Homo sapiens
217 FOS 2353
Proximity Label-MS Homo sapiens
218 RPUSD4 84881
Proximity Label-MS Homo sapiens
219 RPUSD3  
Proximity Label-MS Homo sapiens
220 BAG1 573
Affinity Capture-MS Homo sapiens
221 B3GNT7  
Affinity Capture-MS Homo sapiens
222 COX6C 1345
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
223 EMC2 9694
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
224 RBL2 5934
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
225 TSFM 10102
Proximity Label-MS Homo sapiens
226 UQCRC1 7384
Co-fractionation Homo sapiens
227 CD40LG 959
Reconstituted Complex Homo sapiens
228 ACAD9 28976
Proximity Label-MS Homo sapiens
229 RAF1 5894
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
230 ACTB 60
Co-fractionation Homo sapiens
231 FGFR1 2260
Affinity Capture-MS Homo sapiens
232 RNF2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
233 ARID1A 8289
Negative Genetic Homo sapiens
234 VDAC1 7416
Co-fractionation Homo sapiens
235 CLTC 1213
Co-fractionation Homo sapiens
236 COX2 4513
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
237 HSPD1 3329
Co-fractionation Homo sapiens
238 HSPA9 3313
Co-fractionation Homo sapiens
239 COX7C 1350
Co-fractionation Homo sapiens
240 METTL15  
Proximity Label-MS Homo sapiens
241 DNAJC15  
Proximity Label-MS Homo sapiens
242 NDUFS1 4719
Co-fractionation Homo sapiens
243 AKAP1 8165
Affinity Capture-MS Homo sapiens
244 MCUR1 63933
Proximity Label-MS Homo sapiens
245 NDUFS2 4720
Co-fractionation Homo sapiens
246 MALL  
Affinity Capture-MS Homo sapiens
247 CCDC8  
Affinity Capture-MS Homo sapiens
248 TPM3 7170
Cross-Linking-MS (XL-MS) Homo sapiens
249 GBAS 2631
Co-fractionation Homo sapiens
250 SLC25A3 5250
Co-fractionation Homo sapiens
251 DNAJC28  
Proximity Label-MS Homo sapiens
252 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
253 VWA8 23078
Proximity Label-MS Homo sapiens
254 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
255 PHB2 11331
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
256 FOXL1  
Proximity Label-MS Homo sapiens
257 METTL17  
Proximity Label-MS Homo sapiens
258 PARP1 142
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
259 BKRF1  
Affinity Capture-MS
260 ILF3 3609
Co-fractionation Homo sapiens
261 FAP 2191
Affinity Capture-MS Homo sapiens
262 DNAJC19 131118
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
263 G3bp2  
Two-hybrid Mus musculus
264 TP53 7157
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
265 SIN3A  
Affinity Capture-Western Homo sapiens
266 CIT 11113
Affinity Capture-MS Homo sapiens
267 DTNA  
Affinity Capture-MS Homo sapiens
268 ICT1 3396
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
269 XRCC6 2547
Proximity Label-MS Homo sapiens
270 ATP6V1A 523
Co-fractionation Homo sapiens
271 ZNF746  
Affinity Capture-MS Homo sapiens
272 Aifm1  
Affinity Capture-MS Mus musculus
273 Nop56 67134
Two-hybrid Mus musculus
274 TPTE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
275 PLD6  
Affinity Capture-MS Homo sapiens
276 BCKDHA 593
Co-fractionation Homo sapiens
277 ANXA2 302
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
278 COX5A 9377
Co-fractionation Homo sapiens
279 NAP1L1 4673
Reconstituted Complex Homo sapiens
280 DNAJA3 9093
Proximity Label-MS Homo sapiens
281 LRRC59 55379
Co-fractionation Homo sapiens
282 FKBP9 11328
Co-fractionation Homo sapiens
283 PDHB 5162
Co-fractionation Homo sapiens
284 HDAC1 3065
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
285 CAPZB 832
Affinity Capture-MS Homo sapiens
286 C11orf73 51501
Affinity Capture-MS Homo sapiens
287 C21orf33  
Proximity Label-MS Homo sapiens
288 MYL12A 10627
Co-fractionation Homo sapiens
289 UBR5 51366
Affinity Capture-MS Homo sapiens
290 KLF16  
Affinity Capture-MS Homo sapiens
291 PMPCB 9512
Proximity Label-MS Homo sapiens
292 MMGT1 93380
Affinity Capture-MS Homo sapiens
293 SFXN1 94081
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
294 TMEM70  
Proximity Label-MS Homo sapiens
295 UFL1 23376
Affinity Capture-MS Homo sapiens
296 LONP1 9361
Proximity Label-MS Homo sapiens
297 PAF1 54623
Affinity Capture-MS Homo sapiens
298 MAP1LC3A 84557
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
299 NDUFS8 4728
Co-fractionation Homo sapiens
300 RAB2A 5862
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
301 TAGLN2 8407
Co-fractionation Homo sapiens
302 AARS2  
Proximity Label-MS Homo sapiens
303 FGFR1OP2  
Affinity Capture-MS Homo sapiens
304 C16orf72 29035
Affinity Capture-MS Homo sapiens
305 CYLD  
Affinity Capture-MS Homo sapiens
306 RAB7A 7879
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
307 ATP1A1 476
Co-fractionation Homo sapiens
308 RAB11A 8766
Affinity Capture-MS Homo sapiens
309 C14orf169  
Affinity Capture-MS Homo sapiens
310 CYB5R3 1727
Co-fractionation Homo sapiens
311 MCU 90550
Proximity Label-MS Homo sapiens
312 C1QBP 708
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
313 EP300 2033
Affinity Capture-MS Homo sapiens
314 CUL7 9820
Affinity Capture-MS Homo sapiens
315 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
316 RAB5C 5878
Affinity Capture-MS Homo sapiens
317 C9orf72  
Affinity Capture-MS Homo sapiens
318 AR 367
Affinity Capture-Western Homo sapiens
319 SERBP1 26135
Affinity Capture-MS Homo sapiens
320 VDAC3 7419
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
321 ATXN3 4287
Affinity Capture-MS Homo sapiens
322 PTCH1  
Affinity Capture-MS Homo sapiens
323 PRMT1 3276
Affinity Capture-MS Homo sapiens
324 NDUFS6  
Co-fractionation Homo sapiens
325 CPT1A 1374
Co-fractionation Homo sapiens
326 MECP2 4204
Affinity Capture-MS Homo sapiens
327 MGMT 4255
Affinity Capture-MS Homo sapiens
328 ATP5A1 498
Co-fractionation Homo sapiens
329 NDUFB4 4710
Co-fractionation Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here