Gene description for NOL12
Gene name nucleolar protein 12
Gene symbol NOL12
Other names/aliases Nop25
dJ37E16.7
Species Homo sapiens
 Database cross references - NOL12
ExoCarta ExoCarta_79159
Vesiclepedia VP_79159
Entrez Gene 79159
HGNC 28585
UniProt Q9UGY1  
 NOL12 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for NOL12
Molecular Function
    single-stranded DNA binding GO:0003697 IEA
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    rRNA binding GO:0019843 IBA
    identical protein binding GO:0042802 IPI
Subcellular Localization
    nucleolus GO:0005730 IBA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified NOL12 in sEVs
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for NOL12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNL2 29889
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 RPSA 3921
Affinity Capture-MS Homo sapiens
3 ZNF668  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RPSAP58 388524
Affinity Capture-MS Homo sapiens
5 H1FNT  
Affinity Capture-MS Homo sapiens
6 DDX24 57062
Affinity Capture-MS Homo sapiens
7 ZNF346  
Affinity Capture-MS Homo sapiens
8 KIAA0020 9933
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 RIT1 6016
Negative Genetic Homo sapiens
10 RPL13A 23521
Affinity Capture-MS Homo sapiens
11 RPS19 6223
Affinity Capture-MS Homo sapiens
12 BRD2  
Affinity Capture-MS Homo sapiens
13 RPL14 9045
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 DVL3 1857
Two-hybrid Homo sapiens
15 MRPS27 23107
Affinity Capture-MS Homo sapiens
16 APP 351
Reconstituted Complex Homo sapiens
17 RPL26L1 51121
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 USP36  
Affinity Capture-MS Homo sapiens
19 GPATCH4 54865
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 SART3 9733
Affinity Capture-MS Homo sapiens
21 ZNF189  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 PRR11  
Affinity Capture-MS Homo sapiens
23 KRTAP10-6  
Two-hybrid Homo sapiens
24 CEP70  
Two-hybrid Homo sapiens
25 UBE2O 63893
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SF3B1 23451
Affinity Capture-MS Homo sapiens
27 CHCHD2  
Affinity Capture-MS Homo sapiens
28 CCDC137  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 MRPS5 64969
Affinity Capture-MS Homo sapiens
30 BHLHA15  
Affinity Capture-MS Homo sapiens
31 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 FGF17  
Affinity Capture-MS Homo sapiens
33 KRI1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 MRPS26 64949
Affinity Capture-MS Homo sapiens
35 ADARB1 104
Affinity Capture-MS Homo sapiens
36 PAK1IP1  
Affinity Capture-MS Homo sapiens
37 FYTTD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 RRP8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 RPS3A 6189
Affinity Capture-MS Homo sapiens
40 NHP2 55651
Affinity Capture-MS Homo sapiens
41 MECP2 4204
Affinity Capture-MS Homo sapiens
42 GLTSCR2  
Affinity Capture-MS Homo sapiens
43 MYCN  
Affinity Capture-MS Homo sapiens
44 KRTAP10-7  
Two-hybrid Homo sapiens
45 MAK16  
Affinity Capture-MS Homo sapiens
46 RPL19 6143
Affinity Capture-MS Homo sapiens
47 DVL2 1856
Two-hybrid Homo sapiens
48 RBM19 9904
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 ZCRB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 BRIX1 55299
Affinity Capture-MS Homo sapiens
51 MRPS25 64432
Affinity Capture-MS Homo sapiens
52 MCC 4163
Two-hybrid Homo sapiens
53 LIN28B  
Affinity Capture-MS Homo sapiens
54 RPL4 6124
Affinity Capture-MS Homo sapiens
55 RBM28 55131
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 RPS10 6204
Affinity Capture-MS Homo sapiens
57 YBX2 51087
Affinity Capture-MS Homo sapiens
58 MRPS11  
Affinity Capture-MS Homo sapiens
59 STAU1 6780
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 SRSF6 6431
Affinity Capture-MS Homo sapiens
61 NOP2 4839
Affinity Capture-MS Homo sapiens
62 PTCD3 55037
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 RPL18A 6142
Affinity Capture-MS Homo sapiens
64 DDX10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 RPL31 6160
Affinity Capture-MS Homo sapiens
66 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
67 BEND7 222389
Two-hybrid Homo sapiens
68 DDX54 79039
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 LYAR 55646
Affinity Capture-MS Homo sapiens
70 SPANXN2  
Two-hybrid Homo sapiens
71 MAGEB2 4113
Affinity Capture-MS Homo sapiens
72 DDX27 55661
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 GTPBP4 23560
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 MRPS33  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 DAXX  
Affinity Capture-MS Homo sapiens
76 SSX2IP  
Two-hybrid Homo sapiens
77 RPL11 6135
Affinity Capture-MS Homo sapiens
78 LARP1 23367
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 RSL1D1 26156
Affinity Capture-MS Homo sapiens
80 CNBP 7555
Affinity Capture-MS Homo sapiens
81 FGFBP1 9982
Affinity Capture-MS Homo sapiens
82 PPAN-P2RY11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 SF3B2 10992
Affinity Capture-MS Homo sapiens
84 ABT1 29777
Affinity Capture-MS Homo sapiens
85 RPS2 6187
Affinity Capture-MS Homo sapiens
86 MRPS35 60488
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 ZBTB24  
Affinity Capture-MS Homo sapiens
88 TUBA8 51807
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 TSPYL2  
Two-hybrid Homo sapiens
90 NAT10 55226
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 SRSF1 6426
Affinity Capture-MS Homo sapiens
92 MRPS14  
Affinity Capture-MS Homo sapiens
93 NPM3 10360
Affinity Capture-MS Homo sapiens
94 RPS8 6202
Affinity Capture-MS Homo sapiens
95 SRSF5 6430
Affinity Capture-MS Homo sapiens
96 EBNA1BP2 10969
Affinity Capture-MS Homo sapiens
97 ZCCHC7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 DHX57 90957
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 ZNF512  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 BUD13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 DKC1 1736
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 MYC  
Affinity Capture-MS Homo sapiens
103 NOL12 79159
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
104 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
107 FTSJ3 117246
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 DDX55  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 RPS16 6217
Affinity Capture-MS Homo sapiens
110 RPL13 6137
Affinity Capture-MS Homo sapiens
111 DDX50 79009
Affinity Capture-MS Homo sapiens
112 SURF6  
Affinity Capture-MS Homo sapiens
113 ZNF689  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 SOD2 6648
Two-hybrid Homo sapiens
115 NLE1 54475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 MINA 84864
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 CDCA7L  
Two-hybrid Homo sapiens
118 MRPS31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 SAP18 10284
Two-hybrid Homo sapiens
120 SRSF12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 KNOP1 400506
Affinity Capture-MS Homo sapiens
122 MRPS10 55173
Affinity Capture-MS Homo sapiens
123 NSA2  
Affinity Capture-MS Homo sapiens
124 MRPS18C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 RPS5 6193
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 RPF1  
Affinity Capture-MS Homo sapiens
127 NIFK 84365
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 KRR1 11103
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 LARP7 51574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 NEIL1  
Affinity Capture-MS Homo sapiens
131 TERF1 7013
Two-hybrid Homo sapiens
132 RPL7A 6130
Affinity Capture-MS Homo sapiens
133 RPS6 6194
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 RPL8 6132
Affinity Capture-MS Homo sapiens
135 KRAS 3845
Negative Genetic Homo sapiens
136 DDX31  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 RBM34  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 MRPS18A  
Affinity Capture-MS Homo sapiens
139 MRPS9 64965
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 ZNF770 54989
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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