Gene description for PTPN6
Gene name	protein tyrosine phosphatase, non-receptor type 6
Gene symbol	PTPN6
Other names/aliases	HCP HCPH HPTP1C PTP-1C SH-PTP1 SHP-1 SHP-1L SHP1
Species	Homo sapiens
Database cross references - PTPN6
ExoCarta	ExoCarta_5777
Vesiclepedia	VP_5777
Entrez Gene	5777
HGNC	9658
MIM	176883
UniProt	P29350
PTPN6 identified in sEVs derived from the following tissue/cell type
B cells	20458337
B cells	20458337
B cells	20458337
Platelets	25332113
Platelets	25332113
Platelets	25332113
Thymus	23844026
Urine	19056867

Gene ontology annotations for PTPN6

Molecular Function     phosphotyrosine residue binding GO:0001784 IBA     phosphotyrosine residue binding GO:0001784 IPI     protein tyrosine phosphatase activity GO:0004725 IDA     protein tyrosine phosphatase activity GO:0004725 IMP     protein tyrosine phosphatase activity GO:0004725 TAS     non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IBA     transmembrane receptor protein tyrosine phosphatase activity GO:0005001 IDA     protein binding GO:0005515 IPI     SH3 domain binding GO:0017124 IEA     protein kinase binding GO:0019901 IPI     protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA     SH2 domain binding GO:0042169 IEA     cell adhesion molecule binding GO:0050839 IEA     phosphorylation-dependent protein binding GO:0140031 IPI     histone H2AXY142 phosphatase activity GO:0140793 IEA Biological Process     MAPK cascade GO:0000165 IBA     mitotic cell cycle GO:0000278 IBA     hematopoietic progenitor cell differentiation GO:0002244 IEA     negative regulation of humoral immune response mediated by circulating immunoglobulin GO:0002924 IEA     chromatin remodeling GO:0006338 IEA     protein dephosphorylation GO:0006470 IDA     G protein-coupled receptor signaling pathway GO:0007186 TAS     positive regulation of cell population proliferation GO:0008284 IMP     negative regulation of cell population proliferation GO:0008285 NAS     negative regulation of angiogenesis GO:0016525 IDA     peptidyl-tyrosine phosphorylation GO:0018108 IDA     cytokine-mediated signaling pathway GO:0019221 TAS     cell differentiation GO:0030154 IBA     cell differentiation GO:0030154 IDA     platelet formation GO:0030220 IEA     T cell costimulation GO:0031295 TAS     negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665 ISS     negative regulation of interleukin-6 production GO:0032715 ISS     negative regulation of tumor necrosis factor production GO:0032720 ISS     negative regulation of mast cell activation involved in immune response GO:0033007 IEA     positive regulation of cell adhesion mediated by integrin GO:0033630 IEA     peptidyl-tyrosine dephosphorylation GO:0035335 IMP     megakaryocyte development GO:0035855 IEA     T cell proliferation GO:0042098 IEA     T cell activation GO:0042110 IDA     negative regulation of T cell proliferation GO:0042130 IEA     natural killer cell mediated cytotoxicity GO:0042267 IEA     regulation of apoptotic process GO:0042981 TAS     negative regulation of MAPK cascade GO:0043409 IEA     regulation of B cell differentiation GO:0045577 IEA     negative regulation of innate immune response GO:0045824 IDA     negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 IMP     T cell receptor signaling pathway GO:0050852 IEA     B cell receptor signaling pathway GO:0050853 IEA     negative regulation of B cell receptor signaling pathway GO:0050859 IDA     negative regulation of T cell receptor signaling pathway GO:0050860 IEA     regulation of release of sequestered calcium ion into cytosol GO:0051279 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP     regulation of type I interferon-mediated signaling pathway GO:0060338 TAS     regulation of ERK1 and ERK2 cascade GO:0070372 IDA     platelet aggregation GO:0070527 IEA     negative regulation of inflammatory response to wounding GO:0106015 IDA     CD27 signaling pathway GO:0160162 IDA     negative regulation of neutrophil activation GO:1902564 IDA     epididymis development GO:1905867 IEA     regulation of G1/S transition of mitotic cell cycle GO:2000045 IMP Subcellular Localization     extracellular region GO:0005576 TAS     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     nucleolus GO:0005730 IDA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IDA     cell-cell junction GO:0005911 IEA     membrane GO:0016020 TAS     protein-containing complex GO:0032991 IMP     specific granule lumen GO:0035580 TAS     alpha-beta T cell receptor complex GO:0042105 IEA     extracellular exosome GO:0070062 HDA     tertiary granule lumen GO:1904724 TAS