Gene description for PLCG2
Gene name	phospholipase C, gamma 2 (phosphatidylinositol-specific)
Gene symbol	PLCG2
Other names/aliases	APLAID FCAS3 PLC-IV PLC-gamma-2
Species	Homo sapiens
Database cross references - PLCG2
ExoCarta	ExoCarta_5336
Vesiclepedia	VP_5336
Entrez Gene	5336
HGNC	9066
MIM	600220
UniProt	P16885
PLCG2 identified in sEVs derived from the following tissue/cell type
B cells	20458337
B cells	20458337
Platelets	25332113
Platelets	25332113
Platelets	25332113

Gene ontology annotations for PLCG2

Molecular Function     phosphotyrosine residue binding GO:0001784 IPI     phosphatidylinositol phospholipase C activity GO:0004435 IBA     phosphatidylinositol phospholipase C activity GO:0004435 IDA     phosphatidylinositol phospholipase C activity GO:0004435 IMP     phosphatidylinositol phospholipase C activity GO:0004435 TAS     phospholipase C activity GO:0004629 TAS     protein binding GO:0005515 IPI     protein kinase binding GO:0019901 IPI     scaffold protein binding GO:0097110 IPI     phosphorylation-dependent protein binding GO:0140031 IEA     protein tyrosine kinase binding GO:1990782 IPI Biological Process     cell activation GO:0001775 ISS     response to yeast GO:0001878 ISS     positive regulation of receptor internalization GO:0002092 IEA     stimulatory C-type lectin receptor signaling pathway GO:0002223 ISS     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     toll-like receptor signaling pathway GO:0002224 ISS     macrophage activation involved in immune response GO:0002281 ISS     follicular B cell differentiation GO:0002316 IEA     positive regulation of dendritic cell cytokine production GO:0002732 ISS     phosphatidylinositol biosynthetic process GO:0006661 IDA     phospholipid catabolic process GO:0009395 IEA     positive regulation of gene expression GO:0010628 IMP     positive regulation of gene expression GO:0010628 ISS     positive regulation of epithelial cell migration GO:0010634 IBA     programmed cell death GO:0012501 IEA     Wnt signaling pathway GO:0016055 TAS     regulation of lipid metabolic process GO:0019216 IMP     calcium-mediated signaling GO:0019722 IMP     calcium-mediated signaling GO:0019722 NAS     platelet activation GO:0030168 TAS     B cell differentiation GO:0030183 ISS     lipopolysaccharide-mediated signaling pathway GO:0031663 IMP     positive regulation of type I interferon production GO:0032481 IEA     positive regulation of interleukin-10 production GO:0032733 ISS     positive regulation of interleukin-12 production GO:0032735 ISS     positive regulation of interleukin-2 production GO:0032743 ISS     positive regulation of interleukin-23 production GO:0032747 ISS     positive regulation of interleukin-6 production GO:0032755 ISS     positive regulation of tumor necrosis factor production GO:0032760 ISS     inositol trisphosphate biosynthetic process GO:0032959 IEA     intracellular signal transduction GO:0035556 IDA     intracellular signal transduction GO:0035556 IMP     intracellular signal transduction GO:0035556 ISS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     B cell activation GO:0042113 IDA     negative regulation of programmed cell death GO:0043069 IEA     regulation of canonical NF-kappaB signal transduction GO:0043122 ISS     positive regulation of MAPK cascade GO:0043410 ISS     phosphatidylinositol metabolic process GO:0046488 IBA     phosphatidylinositol-mediated signaling GO:0048015 IBA     response to axon injury GO:0048678 IMP     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISS     positive regulation of calcium-mediated signaling GO:0050850 ISS     T cell receptor signaling pathway GO:0050852 ISS     B cell receptor signaling pathway GO:0050853 IDA     B cell receptor signaling pathway GO:0050853 IMP     B cell receptor signaling pathway GO:0050853 ISS     B cell receptor signaling pathway GO:0050853 TAS     positive regulation of DNA-binding transcription factor activity GO:0051091 ISS     positive regulation of DNA-binding transcription factor activity GO:0051091 ISS     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISS     release of sequestered calcium ion into cytosol GO:0051209 IBA     release of sequestered calcium ion into cytosol GO:0051209 IDA     positive regulation of phagocytosis, engulfment GO:0060100 IMP     positive regulation of macrophage cytokine production GO:0060907 ISS     antifungal innate immune response GO:0061760 ISS     regulation of calcineurin-NFAT signaling cascade GO:0070884 ISS     cellular response to calcium ion GO:0071277 IMP     cellular response to lipid GO:0071396 IMP     positive regulation of neuroinflammatory response GO:0150078 IMP     positive regulation of NLRP3 inflammasome complex assembly GO:1900227 IMP     positive regulation of cell cycle G1/S phase transition GO:1902808 ISS     positive regulation of reactive oxygen species biosynthetic process GO:1903428 ISS     positive regulation of I-kappaB phosphorylation GO:1903721 ISS     cellular response to lectin GO:1990858 ISS Subcellular Localization     cytoplasm GO:0005737 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     ruffle membrane GO:0032587 IBA     ruffle membrane GO:0032587 IDA     membrane raft GO:0045121 ISS     perinuclear region of cytoplasm GO:0048471 IDA     extracellular exosome GO:0070062 HDA     intracellular vesicle GO:0097708 IDA