Gene description for CALML5
Gene name calmodulin-like 5
Gene symbol CALML5
Other names/aliases CLSP
Species Homo sapiens
 Database cross references - CALML5
ExoCarta ExoCarta_51806
Vesiclepedia VP_51806
Entrez Gene 51806
HGNC 18180
MIM 605183
UniProt Q9NZT1  
 CALML5 identified in sEVs derived from the following tissue/cell type
Liver cancer cells 25265333    
Liver cancer cells 25265333    
Liver cancer cells 25265333    
Thymus 23844026    
 Gene ontology annotations for CALML5
Molecular Function
    calcium ion binding GO:0005509 IBA
    protein binding GO:0005515 IPI
    enzyme regulator activity GO:0030234 IBA
Biological Process
    microtubule cytoskeleton organization GO:0000226 IBA
    signal transduction GO:0007165 TAS
    epidermis development GO:0008544 TAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    cytoplasm GO:0005737 IBA
    ficolin-1-rich granule lumen GO:1904813 TAS
 Experiment description of studies that identified CALML5 in sEVs
1
Experiment ID 266
MISEV standards
✘ Biophysical techniques
✔
TSG101|Alix
Enriched markers
✔
CANX|HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Wild type
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 267
MISEV standards
✘ Biophysical techniques
✔
TSG101|Alix
Enriched markers
✔
CANX|HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Transfected with HBx plasmids
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 268
MISEV standards
✘ Biophysical techniques
✔
TSG101|Alix
Enriched markers
✔
CANX|HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Transfected with HBx-null HBV replicon plasmids
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CALML5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Affinity Capture-MS Homo sapiens
2 CCDC94  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 BPHL 670
Affinity Capture-MS Homo sapiens
4 SOX4  
Proximity Label-MS Homo sapiens
5 NRSN1  
Affinity Capture-MS Homo sapiens
6 TLK2  
Affinity Capture-MS Homo sapiens
7 PBRM1 55193
Affinity Capture-Western Homo sapiens
8 ALDH2 217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 C15orf41  
Affinity Capture-MS Homo sapiens
10 RIPPLY3  
Affinity Capture-MS Homo sapiens
11 CSTA 1475
Affinity Capture-MS Homo sapiens
12 PRRT2  
Affinity Capture-MS Homo sapiens
13 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
14 FNDC5  
Affinity Capture-MS Homo sapiens
15 S100A14 57402
Affinity Capture-MS Homo sapiens
16 KAT7  
Affinity Capture-MS Homo sapiens
17 DPPA4  
Affinity Capture-MS Homo sapiens
18 B3GNT2 10678
Affinity Capture-MS Homo sapiens
19 MCM2 4171
Affinity Capture-MS Homo sapiens
20 COPS5 10987
Affinity Capture-MS Homo sapiens
21 TNFRSF19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 OR13C3  
Affinity Capture-MS Homo sapiens
23 UGT1A10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 GDF5 8200
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SLX4  
Affinity Capture-MS Homo sapiens
26 PHF11 51131
Affinity Capture-MS Homo sapiens
27 SFN 2810
Affinity Capture-MS Homo sapiens
28 ZSCAN20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 ASF1A 25842
Affinity Capture-MS Homo sapiens
30 AGPAT1 10554
Affinity Capture-MS Homo sapiens
31 NEDD4 4734
Affinity Capture-MS Homo sapiens
32 C18orf21  
Affinity Capture-MS Homo sapiens
33 FCF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 DYRK4  
Affinity Capture-MS Homo sapiens
35 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 CHMP4C 92421
Affinity Capture-MS Homo sapiens
37 NF2 4771
Affinity Capture-MS Homo sapiens
38 POF1B 79983
Affinity Capture-MS Homo sapiens
39 UBN2  
Affinity Capture-MS Homo sapiens
40 IQUB  
Affinity Capture-MS Homo sapiens
41 CABIN1  
Affinity Capture-MS Homo sapiens
42 C16orf70  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 ZDHHC19  
Affinity Capture-MS Homo sapiens
44 FUNDC2 65991
Affinity Capture-MS Homo sapiens
45 CERS3  
Affinity Capture-MS Homo sapiens
46 RNF115  
Affinity Capture-MS Homo sapiens
47 UBAC2 337867
Affinity Capture-MS Homo sapiens
48 Smarcc1  
Affinity Capture-MS Mus musculus
49 CFDP1  
Affinity Capture-MS Homo sapiens
50 SFMBT1 51460
Affinity Capture-MS Homo sapiens
51 ITLN2  
Affinity Capture-MS Homo sapiens
52 FIBIN  
Affinity Capture-MS Homo sapiens
53 LRRN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 SARAF  
Affinity Capture-MS Homo sapiens
55 PIGT 51604
Affinity Capture-MS Homo sapiens
56 PLK1 5347
Affinity Capture-Western Homo sapiens
57 SSUH2  
Affinity Capture-MS Homo sapiens
58 SPRR1B 6699
Affinity Capture-MS Homo sapiens
59 HCN1  
Affinity Capture-MS Homo sapiens
60 UPK1A 11045
Affinity Capture-MS Homo sapiens
61 DDX39B 7919
Affinity Capture-MS Homo sapiens
62 LUCAT1  
Affinity Capture-RNA Homo sapiens
63 FSTL1 11167
Affinity Capture-MS Homo sapiens
64 CASP14 23581
Affinity Capture-MS Homo sapiens
65 RHBDD1 84236
Affinity Capture-MS Homo sapiens
66 SERPINB3 6317
Affinity Capture-MS Homo sapiens
67 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
68 GFER  
Affinity Capture-MS Homo sapiens
69 IVL 3713
Affinity Capture-MS Homo sapiens
70 FANCD2  
Affinity Capture-MS Homo sapiens
71 CCNC  
Affinity Capture-MS Homo sapiens
72 RC3H2  
Affinity Capture-MS Homo sapiens
73 CCNYL1 151195
Affinity Capture-MS Homo sapiens
74 ASCC1 51008
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 FAM60A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 JADE1  
Affinity Capture-MS Homo sapiens
78 PCP4  
Affinity Capture-MS Homo sapiens
79 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
80 NR3C1 2908
Proximity Label-MS Homo sapiens
81 ZC3HC1  
Affinity Capture-MS Homo sapiens
82 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
83 FTH1 2495
Affinity Capture-MS Homo sapiens
84 PLD5  
Affinity Capture-MS Homo sapiens
85 LGALS7 3963
Affinity Capture-MS Homo sapiens
86 SERPINB5 5268
Affinity Capture-MS Homo sapiens
87 C21orf59 56683
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 YWHAQ 10971
Affinity Capture-MS Homo sapiens
89 MAPK6  
Affinity Capture-MS Homo sapiens
90 FRMD1  
Affinity Capture-MS Homo sapiens
91 TRIM44  
Affinity Capture-MS Homo sapiens
92 FOS 2353
Affinity Capture-MS Homo sapiens
93 FABP5 2171
Affinity Capture-MS Homo sapiens
94 ITGA9 3680
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 BLMH 642
Affinity Capture-MS Homo sapiens
96 SLC37A4 2542
Affinity Capture-MS Homo sapiens
97 STX17 55014
Affinity Capture-MS Homo sapiens
98 HMGB1P1 10357
Affinity Capture-MS Homo sapiens
99 CDC42EP4  
Affinity Capture-MS Homo sapiens
100 G3BP1 10146
Affinity Capture-MS Homo sapiens
101 DSP 1832
Affinity Capture-MS Homo sapiens
102 CDAN1 146059
Affinity Capture-MS Homo sapiens
103 RAD21 5885
Affinity Capture-MS Homo sapiens
104 FBXW11  
Affinity Capture-Western Homo sapiens
105 KIAA0907  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 ANXA2 302
Affinity Capture-MS Homo sapiens
107 SLC25A6 293
Affinity Capture-MS Homo sapiens
108 JUP 3728
Affinity Capture-MS Homo sapiens
109 TP53 7157
Affinity Capture-MS Homo sapiens
110 SCGB1D1  
Affinity Capture-MS Homo sapiens
111 RBM24 221662
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 USP1 7398
Affinity Capture-MS Homo sapiens
113 MCM5 4174
Affinity Capture-MS Homo sapiens
114 CTSD 1509
Affinity Capture-MS Homo sapiens
115 CAPZA2 830
Affinity Capture-MS Homo sapiens
116 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 C1orf35  
Affinity Capture-MS Homo sapiens
118 SSBP2  
Affinity Capture-MS Homo sapiens
119 TREX2  
Affinity Capture-MS Homo sapiens
120 PTDSS1 9791
Affinity Capture-MS Homo sapiens
121 MS4A6E  
Affinity Capture-MS Homo sapiens
122 S100A9 6280
Affinity Capture-MS Homo sapiens
123 KLHL11  
Affinity Capture-MS Homo sapiens
124 CACUL1  
Affinity Capture-MS Homo sapiens
125 MBNL1 4154
Affinity Capture-MS Homo sapiens
126 KIR3DS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 MAGED1 9500
Affinity Capture-MS Homo sapiens
128 SERPINB12 89777
Affinity Capture-MS Homo sapiens
129 CYLD  
Affinity Capture-MS Homo sapiens
130 ACTA2 59
Affinity Capture-MS Homo sapiens
131 PINK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 GPR18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 GOT1 2805
Affinity Capture-MS Homo sapiens
134 PDE4DIP 9659
Affinity Capture-MS Homo sapiens
135 HIRA  
Affinity Capture-MS Homo sapiens
136 OR2A4 79541
Affinity Capture-MS Homo sapiens
137 UBN1  
Affinity Capture-MS Homo sapiens
138 CCR1  
Affinity Capture-MS Homo sapiens
139 GUCY1A3  
Affinity Capture-MS Homo sapiens
140 P2RX6  
Affinity Capture-MS Homo sapiens
141 POC5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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