Gene description for ACTA2
Gene name actin, alpha 2, smooth muscle, aorta
Gene symbol ACTA2
Other names/aliases AAT6
ACTSA
MYMY5
Species Homo sapiens
 Database cross references - ACTA2
ExoCarta ExoCarta_59
Vesiclepedia VP_59
Entrez Gene 59
HGNC 130
MIM 102620
UniProt P62736  
 ACTA2 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 17956143    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Keratinocytes 19530224    
Keratinocytes 19530224    
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Urine 15326289    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for ACTA2
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    hydrolase activity GO:0016787 IEA
    protein kinase binding GO:0019901 ISS
Biological Process
    regulation of blood pressure GO:0008217 IEA
    response to virus GO:0009615 IEP
    positive regulation of gene expression GO:0010628 ISS
    vascular associated smooth muscle contraction GO:0014829 IEA
    positive regulation of hepatic stellate cell migration GO:0061870 IEA
    positive regulation of hepatic stellate cell contraction GO:0061874 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA
    cellular response to transforming growth factor beta stimulus GO:0071560 IEA
    juxtaglomerular apparatus development GO:0072051 IEA
    glomerular mesangial cell development GO:0072144 IEP
    mesenchyme migration GO:0090131 ISS
    positive regulation of hepatic stellate cell activation GO:2000491 IEA
Subcellular Localization
    stress fiber GO:0001725 IEA
    basement membrane GO:0005604 IEA
    extracellular space GO:0005615 HDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    actin cytoskeleton GO:0015629 IBA
    lamellipodium GO:0030027 ISS
    filopodium GO:0030175 ISS
    smooth muscle contractile fiber GO:0030485 IEA
    motile cilium GO:0031514 IEA
    protein-containing complex GO:0032991 IDA
    cell body GO:0044297 ISS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified ACTA2 in sEVs
1
Experiment ID 20
MISEV standards
✔
EM
Biophysical techniques
✔
HSP90|CD63|CD81|LAMP1
Enriched markers
✔
GOLGA2|cytochrome c
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors "Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS"
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
2
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 189
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 190
MISEV standards
✔
EM
Biophysical techniques
✔
HSC70
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors "Chavez-Muñoz C, Kilani RT, Ghahary A."
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
8
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
10
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 136
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name PC3 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
14
Experiment ID 137
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB6|CD10
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name PC3 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
15
Experiment ID 140
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
16
Experiment ID 142
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
17
Experiment ID 143
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
18
Experiment ID 144
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
19
Experiment ID 145
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD10
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
20
Experiment ID 146
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name RWPE - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
21
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
23
Experiment ID 13
MISEV standards
✔
IEM
Biophysical techniques
✔
Alix|RAB4|RAB5B|RAB11|TSG101|CD9|AQP2|AQP1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors "Pisitkun T, Shen RF, Knepper MA"
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
24
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
25
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
26
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ACTA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CRYGD  
Affinity Capture-MS Homo sapiens
2 RALY 22913
Affinity Capture-MS Homo sapiens
3 CAPNS2 84290
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ZSCAN29  
Affinity Capture-MS Homo sapiens
5 MAP1LC3C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 UBE2H 7328
Affinity Capture-MS Homo sapiens
7 SCIN 85477
Affinity Capture-MS Homo sapiens
8 SLCO1B3  
Affinity Capture-MS Homo sapiens
9 TWF2 11344
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 UBL4A 8266
Affinity Capture-MS Homo sapiens
11 GSTP1 2950
Co-fractionation Homo sapiens
12 PEAR1 375033
Affinity Capture-MS Homo sapiens
13 DHCR24 1718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ABRA  
Affinity Capture-MS Homo sapiens
15 PTMA 5757
Cross-Linking-MS (XL-MS) Homo sapiens
16 THRB 7068
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 GPR34  
Affinity Capture-MS Homo sapiens
18 NAA11 84779
Affinity Capture-MS Homo sapiens
19 YWHAE 7531
Co-fractionation Homo sapiens
20 GC 2638
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CAP1 10487
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ACTC1 70
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
23 DBN1 1627
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 MYOC 4653
Two-hybrid Homo sapiens
25 UBE3A 7337
Reconstituted Complex Homo sapiens
26 CCT4 10575
Co-crystal Structure Homo sapiens
27 RPL14 9045
Co-fractionation Homo sapiens
28 MCCC1 56922
Affinity Capture-MS Homo sapiens
29 MYH11 4629
Co-fractionation Homo sapiens
30 CAND1 55832
Affinity Capture-MS Homo sapiens
31 CBY1  
Affinity Capture-MS Homo sapiens
32 IL36A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 LIM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 ADAM19 8728
Affinity Capture-MS Homo sapiens
35 POTEF 728378
Cross-Linking-MS (XL-MS) Homo sapiens
36 THAP11 57215
Affinity Capture-MS Homo sapiens
37 MRPS5 64969
Affinity Capture-MS Homo sapiens
38 POTEE 445582
Cross-Linking-MS (XL-MS) Homo sapiens
39 ADAM21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 C9orf43  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 REG3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 PECR 55825
Affinity Capture-MS Homo sapiens
43 ALOX12 239
Affinity Capture-Western Homo sapiens
44 B3GNT2 10678
Affinity Capture-MS Homo sapiens
45 SIRT2 22933
Affinity Capture-MS Homo sapiens
46 FAM150B  
Affinity Capture-MS Homo sapiens
47 PFN3  
Affinity Capture-MS Homo sapiens
48 FAM53B  
Affinity Capture-MS Homo sapiens
49 MCM2 4171
Affinity Capture-MS Homo sapiens
50 GNAO1 2775
Affinity Capture-MS Homo sapiens
51 LINC01587  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 PTPRZ1  
Affinity Capture-MS Homo sapiens
53 IL17RE  
Affinity Capture-MS Homo sapiens
54 ACTG2 72
Cross-Linking-MS (XL-MS) Homo sapiens
55 HEY1  
Affinity Capture-MS Homo sapiens
56 COPS5 10987
Affinity Capture-MS Homo sapiens
57 DRG1 4733
Affinity Capture-MS Homo sapiens
58 MUC1 4582
Affinity Capture-MS Homo sapiens
59 KLF6  
Proximity Label-MS Homo sapiens
60 ACTR1A 10121
Affinity Capture-MS Homo sapiens
61 NAT6  
Affinity Capture-MS Homo sapiens
62 NPVF  
Affinity Capture-MS Homo sapiens
63 CNN2 1265
Co-fractionation Homo sapiens
64 PCNX  
Affinity Capture-MS Homo sapiens
65 CTSD 1509
Affinity Capture-MS Homo sapiens
66 WASH1 100287171
Affinity Capture-MS Homo sapiens
67 LRRC20  
Affinity Capture-MS Homo sapiens
68 KRT78 196374
Affinity Capture-MS Homo sapiens
69 RANBP17  
Affinity Capture-MS Homo sapiens
70 CALML5 51806
Affinity Capture-MS Homo sapiens
71 RNF216  
Affinity Capture-MS Homo sapiens
72 ST8SIA4 7903
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 EMCN  
Affinity Capture-MS Homo sapiens
74 MAP3K6  
Affinity Capture-MS Homo sapiens
75 ETFA 2108
Affinity Capture-MS Homo sapiens
76 SPRTN  
Affinity Capture-MS Homo sapiens
77 MRPS7 51081
Co-fractionation Homo sapiens
78 PFN2 5217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 PLEC 5339
Cross-Linking-MS (XL-MS) Homo sapiens
80 CUL1 8454
Affinity Capture-MS Homo sapiens
81 TFCP2 7024
Affinity Capture-MS Homo sapiens
82 C7orf33  
Affinity Capture-MS Homo sapiens
83 C5orf28  
Affinity Capture-MS Homo sapiens
84 ICE2  
Affinity Capture-MS Homo sapiens
85 OCLM  
Affinity Capture-MS Homo sapiens
86 SCMH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 MAS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 GEMIN2 8487
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 ENOPH1 58478
Affinity Capture-MS Homo sapiens
90 LCMT2 9836
Affinity Capture-MS Homo sapiens
91 YWHAB 7529
Co-fractionation Homo sapiens
92 ACTG1 71
Cross-Linking-MS (XL-MS) Homo sapiens
93 HEXIM1 10614
Affinity Capture-MS Homo sapiens
94 ZYX 7791
Co-fractionation Homo sapiens
95 TMEM220  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 ZMAT3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 OSTM1 28962
Affinity Capture-MS Homo sapiens
98 TREX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 POF1B 79983
Affinity Capture-MS Homo sapiens
100 VAV1 7409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 MTHFS 10588
Affinity Capture-MS Homo sapiens
102 GJA1 2697
Affinity Capture-MS Homo sapiens
103 IFNG 3458
Affinity Capture-MS Homo sapiens
104 USP11 8237
Affinity Capture-MS Homo sapiens
105 KLHL3  
Affinity Capture-MS Homo sapiens
106 TEX35  
Affinity Capture-MS Homo sapiens
107 CUL4B 8450
Affinity Capture-MS Homo sapiens
108 PARK2  
Affinity Capture-MS Homo sapiens
109 ZMAT5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 SLC9A5  
Affinity Capture-MS Homo sapiens
111 ERBB3 2065
Affinity Capture-MS Homo sapiens
112 LY6G5B  
Affinity Capture-MS Homo sapiens
113 GUCY2F  
Affinity Capture-MS Homo sapiens
114 C1orf101  
Affinity Capture-MS Homo sapiens
115 CCT5 22948
Co-crystal Structure Homo sapiens
116 MICU2 221154
Affinity Capture-MS Homo sapiens
117 PSPN  
Affinity Capture-MS Homo sapiens
118 ACTA1 58
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
119 APBB1IP 54518
Affinity Capture-MS Homo sapiens
120 SCGB1A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 RPA2 6118
Affinity Capture-MS Homo sapiens
122 MYH9 4627
Co-fractionation Homo sapiens
123 BCL7C  
Affinity Capture-MS Homo sapiens
124 RAB24 53917
Affinity Capture-MS Homo sapiens
125 PILRA 29992
Affinity Capture-MS Homo sapiens
126 LYSMD3  
Affinity Capture-MS Homo sapiens
127 DCTN1 1639
Affinity Capture-MS Homo sapiens
128 FSCN1 6624
Co-fractionation Homo sapiens
129 YWHAQ 10971
Affinity Capture-MS Homo sapiens
130 CENPC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 ACTB 60
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
132 MYH10 4628
Co-fractionation Homo sapiens
133 LOC100288778  
Affinity Capture-MS Homo sapiens
134 PHACTR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 CUL2 8453
Affinity Capture-MS Homo sapiens
136 RPS16 6217
Co-fractionation Homo sapiens
137 VENTX  
Affinity Capture-MS Homo sapiens
138 YAP1 10413
Affinity Capture-MS Homo sapiens
139 RPS15A 6210
Co-fractionation Homo sapiens
140 PNKP 11284
Affinity Capture-MS Homo sapiens
141 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
142 GM2A 2760
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 NOP56 10528
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 CGREF1 10669
Affinity Capture-MS Homo sapiens
145 AKIRIN2  
Affinity Capture-MS Homo sapiens
146 SPATA22  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 PLEKHG6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 AFM 173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
149 LIMA1 51474
Cross-Linking-MS (XL-MS) Homo sapiens
150 PKMYT1  
Affinity Capture-MS Homo sapiens
151 DCTN3 11258
Affinity Capture-MS Homo sapiens
152 LRRTM2  
Affinity Capture-MS Homo sapiens
153 SV2A 9900
Affinity Capture-MS Homo sapiens
154 PPP1R1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 IVL 3713
Affinity Capture-MS Homo sapiens
156 SFN 2810
Affinity Capture-MS Homo sapiens
157 ACTBL2 345651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
158 FBXO40  
Affinity Capture-MS Homo sapiens
159 RPL23 9349
Affinity Capture-MS Homo sapiens
160 STARD6  
Affinity Capture-MS Homo sapiens
161 SYTL5 94122
Affinity Capture-MS Homo sapiens
162 POTEI 653269
Cross-Linking-MS (XL-MS) Homo sapiens
163 RNASE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 JADE1  
Affinity Capture-MS Homo sapiens
165 NPTN 27020
Affinity Capture-MS Homo sapiens
166 ENTPD6  
Affinity Capture-MS Homo sapiens
167 PRG2  
Affinity Capture-MS Homo sapiens
168 CUL3 8452
Affinity Capture-MS Homo sapiens
169 DEFB135  
Affinity Capture-MS Homo sapiens
170 SRSF5 6430
Affinity Capture-MS Homo sapiens
171 UHRF2  
Affinity Capture-MS Homo sapiens
172 EGFR 1956
Affinity Capture-MS Homo sapiens
173 FBXO30 84085
Affinity Capture-MS Homo sapiens
174 DUSP16  
Affinity Capture-MS Homo sapiens
175 RBM18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
176 HTR2C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
177 PFN1 5216
Affinity Capture-MS Homo sapiens
178 C11orf70  
Affinity Capture-MS Homo sapiens
179 LGALS7 3963
Affinity Capture-MS Homo sapiens
180 SERPINB5 5268
Affinity Capture-MS Homo sapiens
181 KIAA0895  
Affinity Capture-MS Homo sapiens
182 MYO1C 4641
Co-fractionation Homo sapiens
183 SAMD4B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
184 MRPL47 57129
Co-fractionation Homo sapiens
185 SGTB  
Affinity Capture-MS Homo sapiens
186 SERP2  
Affinity Capture-MS Homo sapiens
187 SIX3  
Affinity Capture-MS Homo sapiens
188 TPM1 7168
Co-fractionation Homo sapiens
189 OR7E24  
Affinity Capture-MS Homo sapiens
190 PGBD1  
Affinity Capture-MS Homo sapiens
191 RPA3 6119
Affinity Capture-MS Homo sapiens
192 PCYT1B 9468
Co-crystal Structure Homo sapiens
193 IGSF3 3321
Affinity Capture-MS Homo sapiens
194 CPLX4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
195 TMOD3 29766
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
196 CFL1 1072
Affinity Capture-MS Homo sapiens
197 POTEKP 440915
Affinity Capture-MS Homo sapiens
198 TCP11L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
199 CGN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
200 MOB2 81532
Affinity Capture-MS Homo sapiens
201 FNTB 2342
Affinity Capture-MS Homo sapiens
202 RPL18 6141
Co-fractionation Homo sapiens
203 P2RY10  
Affinity Capture-MS Homo sapiens
204 CR1L 1379
Affinity Capture-MS Homo sapiens
205 PDCL3 79031
Affinity Capture-MS Homo sapiens
206 NPB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
207 NCF1  
Affinity Capture-Western Homo sapiens
208 AARS 16
Co-fractionation Homo sapiens
209 CDK10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
210 ARAF 369
Affinity Capture-MS Homo sapiens
211 RPS23 6228
Co-fractionation Homo sapiens
212 RNF217  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
213 RBM17 84991
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
214 EFNA1  
Affinity Capture-MS Homo sapiens
215 PLEKHG3 26030
Affinity Capture-MS Homo sapiens
216 UBAP1 51271
Co-fractionation Homo sapiens
217 GSN 2934
Affinity Capture-MS Homo sapiens
218 DUSP19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
219 TMCC2  
Affinity Capture-MS Homo sapiens
220 YBX1 4904
Protein-RNA Homo sapiens
221 NEXN 91624
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
222 Racgap1 26934
Affinity Capture-MS Mus musculus
223 SPTAN1 6709
Co-fractionation Homo sapiens
224 TFDP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
225 MRPS2 51116
Co-fractionation Homo sapiens
226 SHBG 6462
Two-hybrid Homo sapiens
227 DUSP10 11221
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
228 UBXN4 23190
Affinity Capture-MS Homo sapiens
229 PIGM  
Affinity Capture-MS Homo sapiens
230 TP53 7157
Affinity Capture-MS Homo sapiens
231 SIDT2 51092
Affinity Capture-MS Homo sapiens
232 SSH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
233 IL12A  
Affinity Capture-MS Homo sapiens
234 GCNT3 9245
Affinity Capture-MS Homo sapiens
235 ANKRD33  
Affinity Capture-MS Homo sapiens
236 ZNF433  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
237 DDX3X 1654
Affinity Capture-MS Homo sapiens
238 KRTAP19-6  
Affinity Capture-MS Homo sapiens
239 MFSD4  
Affinity Capture-MS Homo sapiens
240 DNA2  
Affinity Capture-MS Homo sapiens
241 MAP3K4 4216
Affinity Capture-MS Homo sapiens
242 RPA1 6117
Affinity Capture-MS Homo sapiens
243 C6orf201  
Affinity Capture-MS Homo sapiens
244 LOC100506688  
Affinity Capture-MS Homo sapiens
245 RYK 6259
Affinity Capture-MS Homo sapiens
246 POTEJ 653781
Cross-Linking-MS (XL-MS) Homo sapiens
247 CHRM4  
Affinity Capture-MS Homo sapiens
248 RPS4X 6191
Co-fractionation Homo sapiens
249 CAP2 10486
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
250 TRIM9  
Affinity Capture-MS Homo sapiens
251 CREBBP  
Affinity Capture-MS Homo sapiens
252 PNMA1 9240
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
253 FAM120AOS  
Affinity Capture-MS Homo sapiens
254 CALCB  
Affinity Capture-MS Homo sapiens
255 WFDC8  
Affinity Capture-MS Homo sapiens
256 BUB3 9184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
257 FMNL3 91010
Affinity Capture-MS Homo sapiens
258 FAM227B  
Affinity Capture-MS Homo sapiens
259 RPS26 6231
Co-fractionation Homo sapiens
260 EXOC3L1  
Affinity Capture-MS Homo sapiens
261 RPL10A 4736
Co-fractionation Homo sapiens
262 PRR34  
Affinity Capture-MS Homo sapiens
263 NAA30 122830
Affinity Capture-MS Homo sapiens
264 KDM1A 23028
Proximity Label-MS Homo sapiens
265 ADRA1D  
Affinity Capture-MS Homo sapiens
266 Dctn3  
Affinity Capture-MS Mus musculus
267 LRRK2 120892
Affinity Capture-MS Homo sapiens
268 ERRFI1 54206
Affinity Capture-MS Homo sapiens
269 TEAD4  
Affinity Capture-MS Homo sapiens
270 RPL7A 6130
Co-fractionation Homo sapiens
271 ZNF284  
Affinity Capture-MS Homo sapiens
272 YIPF2 78992
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
273 TNNC2  
Affinity Capture-MS Homo sapiens
274 KYNU  
Affinity Capture-MS Homo sapiens
275 DTWD1  
Affinity Capture-MS Homo sapiens
276 OAZ1 4946
Affinity Capture-MS Homo sapiens
277 C9orf72  
Affinity Capture-MS Homo sapiens
278 LGALS3 3958
Affinity Capture-MS Homo sapiens
279 SMURF2 64750
Affinity Capture-MS Homo sapiens
280 ARMC10 83787
Affinity Capture-MS Homo sapiens
281 OR1A1  
Affinity Capture-MS Homo sapiens
282 C19orf80  
Affinity Capture-MS Homo sapiens
283 RPL17 6139
Co-fractionation Homo sapiens
284 EP300 2033
Affinity Capture-MS Homo sapiens
285 CASQ2 845
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
286 RNF183  
Affinity Capture-MS Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here