Gene description for MPC2
Gene name mitochondrial pyruvate carrier 2
Gene symbol MPC2
Other names/aliases BRP44
Species Homo sapiens
 Database cross references - MPC2
ExoCarta ExoCarta_25874
Vesiclepedia VP_25874
Entrez Gene 25874
HGNC 24515
MIM 614737
UniProt O95563  
 MPC2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for MPC2
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    pyruvate transmembrane transporter activity GO:0050833 IBA
Biological Process
    acetyl-CoA biosynthetic process from pyruvate GO:0006086 IEA
    mitochondrial pyruvate transmembrane transport GO:0006850 IBA
    mitochondrial pyruvate transmembrane transport GO:0006850 IDA
    mitochondrial pyruvate transmembrane transport GO:0006850 ISS
    positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IEA
Subcellular Localization
    nucleus GO:0005634 HDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IBA
    mitochondrial inner membrane GO:0005743 IDA
    inner mitochondrial membrane protein complex GO:0098800 ISS
 Experiment description of studies that identified MPC2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MPC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAGEA8  
Affinity Capture-MS Homo sapiens
2 FTL 2512
Affinity Capture-MS Homo sapiens
3 MPC2 25874
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 C15orf48  
Affinity Capture-MS Homo sapiens
5 IFNGR2  
Affinity Capture-MS Homo sapiens
6 ADAM18  
Affinity Capture-MS Homo sapiens
7 SLC25A12 8604
Proximity Label-MS Homo sapiens
8 MINOS1  
Two-hybrid Homo sapiens
9 APOO 79135
Proximity Label-MS Homo sapiens
10 C2orf57  
Two-hybrid Homo sapiens
11 SYT16  
Two-hybrid Homo sapiens
12 RPA2 6118
Proximity Label-MS Homo sapiens
13 SLC1A5 6510
Affinity Capture-MS Homo sapiens
14 DIABLO 56616
Two-hybrid Homo sapiens
15 EGFR 1956
Affinity Capture-MS Homo sapiens
16 SLC18A2  
Affinity Capture-MS Homo sapiens
17 NDUFA4 4697
Affinity Capture-MS Homo sapiens
18 SLCO1B1  
Affinity Capture-MS Homo sapiens
19 MPC1 51660
Affinity Capture-MS Homo sapiens
20 TTC30B  
Affinity Capture-MS Homo sapiens
21 SLC39A9 55334
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SFXN1 94081
Proximity Label-MS Homo sapiens
23 APOC1  
Two-hybrid Homo sapiens
24 CLEC12B  
Affinity Capture-MS Homo sapiens
25 OGFOD3 79701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 RPA3 6119
Proximity Label-MS Homo sapiens
27 LRRK2 120892
Affinity Capture-MS Homo sapiens
28 COQ9  
Affinity Capture-MS Homo sapiens
29 ATP2B2 491
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 AQP3  
Affinity Capture-MS Homo sapiens
31 SLC39A12  
Affinity Capture-MS Homo sapiens
32 TIMM17B  
Two-hybrid Homo sapiens
33 RPLP1 6176
Two-hybrid Homo sapiens
34 CIDEB  
Two-hybrid Homo sapiens
35 SLC1A1 6505
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 EIF3F 8665
Affinity Capture-MS Homo sapiens
37 SDF4 51150
Affinity Capture-MS Homo sapiens
38 FLOT2 2319
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 TMEM171  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 PIPSL 266971
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MPC2 is involved
PathwayEvidenceSource
Aerobic respiration and respiratory electron transport IEA Reactome
Metabolism IEA Reactome
Pyruvate metabolism IEA Reactome





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