Gene description for CXCL1
Gene name chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Gene symbol CXCL1
Other names/aliases FSP
GRO1
GROa
MGSA
MGSA-a
NAP-3
SCYB1
Species Homo sapiens
 Database cross references - CXCL1
ExoCarta ExoCarta_2919
Vesiclepedia VP_2919
Entrez Gene 2919
HGNC 4602
MIM 155730
UniProt P09341  
 CXCL1 identified in sEVs derived from the following tissue/cell type
Plasma 34112803    
 Gene ontology annotations for CXCL1
Molecular Function
    signaling receptor binding GO:0005102 TAS
    protein binding GO:0005515 IPI
    enzyme activator activity GO:0008047 TAS
    growth factor activity GO:0008083 TAS
Biological Process
    chemotaxis GO:0006935 TAS
    signal transduction GO:0007165 TAS
    G protein-coupled receptor signaling pathway GO:0007186 TAS
    nervous system development GO:0007399 TAS
    negative regulation of cell population proliferation GO:0008285 TAS
    actin cytoskeleton organization GO:0030036 TAS
    killing of cells of another organism GO:0031640 IDA
    intracellular signal transduction GO:0035556 TAS
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    specific granule lumen GO:0035580 TAS
    tertiary granule lumen GO:1904724 TAS
 Experiment description of studies that identified CXCL1 in sEVs
1
Experiment ID 525
MISEV standards
✔
EM
Biophysical techniques
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 34112803    
Organism Homo sapiens
Experiment description Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
Authors "Lima LG, Ham S, Shin H, Chai EPZ, Lek ESH, Lobb RJ, Müller AF, Mathivanan S, Yeo B, Choi Y, Parker BS, Möller A. "
Journal name Nat Commun
Publication year 2021
Sample Plasma
Sample name Pooled plasma from healthy subjects
Isolation/purification methods Size exclusion chromatography
Centrifugal ultrafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
 Protein-protein interactions for CXCL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MEOX2  
Two-hybrid Homo sapiens
2 CXCL1 2919
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
3 CXCL2 2920
Affinity Capture-MS Homo sapiens
4 CXCL5  
Reconstituted Complex Homo sapiens
5 SRSF1 6426
Affinity Capture-RNA Homo sapiens
6 BIRC2  
Affinity Capture-MS Homo sapiens
7 DIABLO 56616
Affinity Capture-MS Homo sapiens
8 SEH1L 81929
Affinity Capture-MS Homo sapiens
9 CXCL3  
Affinity Capture-MS Homo sapiens
10 CCL11  
Reconstituted Complex Homo sapiens
11 XIAP  
Affinity Capture-MS Homo sapiens
12 TRAF2 7186
Affinity Capture-MS Homo sapiens
13 TBK1 29110
Affinity Capture-MS Homo sapiens
14 HIPK2 28996
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
15 CXCL6  
Reconstituted Complex Homo sapiens
16 ACKR1  
Reconstituted Complex Homo sapiens
17 BIRC6 57448
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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