Gene description for CELSR1
Gene name cadherin, EGF LAG seven-pass G-type receptor 1
Gene symbol CELSR1
Other names/aliases ADGRC1
CDHF9
FMI2
HFMI2
ME2
Species Homo sapiens
 Database cross references - CELSR1
ExoCarta ExoCarta_9620
Entrez Gene 9620
HGNC 1850
MIM 604523
UniProt Q9NYQ6  
 CELSR1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for CELSR1
Molecular Function
    G-protein coupled receptor activity GO:0004930 NAS
    protein dimerization activity GO:0046983 NAS
    calcium ion binding GO:0005509 IEA
    transmembrane signaling receptor activity GO:0004888 NAS
Biological Process
    planar cell polarity pathway involved in neural tube closure GO:0090179 IEA
    regulation of actin cytoskeleton organization GO:0032956 IEA
    protein localization involved in establishment of planar polarity GO:0090251 IEA
    inner ear morphogenesis GO:0042472 IEA
    anterior/posterior pattern specification GO:0009952 IEA
    locomotory behavior GO:0007626 IEA
    wound healing GO:0042060 IEA
    lateral sprouting involved in lung morphogenesis GO:0060490 IEA
    G-protein coupled receptor signaling pathway GO:0007186 NAS
    central nervous system development GO:0007417 TAS
    Rho protein signal transduction GO:0007266 IEA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    establishment of planar polarity of embryonic epithelium GO:0042249 IEA
    establishment of body hair planar orientation GO:0048105 IEA
    establishment of planar polarity GO:0001736 ISS
    planar dichotomous subdivision of terminal units involved in lung branching morphogenesis GO:0060489 IEA
    apical protein localization GO:0045176 IEA
    hair follicle development GO:0001942 IEA
    orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis GO:0060488 IEA
    neural tube closure GO:0001843 ISS
    neuron migration GO:0001764 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    plasma membrane GO:0005886 IDA
    integral component of membrane GO:0016021 TAS
    integral component of plasma membrane GO:0005887 TAS
 Experiment description of studies that identified CELSR1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for CELSR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSAP 5660
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CELSR1 is involved
No pathways found





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