Experiment description of studies that identified CELSR1 in sEVs

1 Experiment ID 235 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|Alix|HSC70|GAPDH Enriched markers ✔ HSP90B1 Negative markers ✔ qNano Particle analysis Identified molecule mRNA Identification method RNA Sequencing PubMed ID 26054723     Organism Homo sapiens Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N" Journal name Carcinogenesis Publication year 2015 Sample Hepatocellular carcinoma cells Sample name HKCI-8 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.13-1.19 g/mL Molecules identified in the study Protein RNA Methods used in the study Western blotting Mass spectrometry RT-PCR RNA Sequencing

2 Experiment ID 834 MISEV standards ✔ EM Biophysical techniques ✔ LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101 Enriched markers ✔ CANX Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 35333565     Organism Homo sapiens Experiment description LAMP2A regulates the loading of proteins into exosomes Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P" Journal name Sci Adv Publication year 2022 Sample Retinal pigment epithelial cells Sample name ARPE-19 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry

3 Experiment ID 835 MISEV standards ✔ EM Biophysical techniques ✔ CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101 Enriched markers ✔ CANX Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 35333565     Organism Homo sapiens Experiment description LAMP2A regulates the loading of proteins into exosomes Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P" Journal name Sci Adv Publication year 2022 Sample Retinal pigment epithelial cells Sample name ARPE-19 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectrometry

Protein-protein interactions for CELSR1

Protein Interactor ExoCarta ID Identification method PubMed Species 1 LY86   Affinity Capture-MS Homo sapiens 2 C2CD4B   Affinity Capture-MS Homo sapiens 3 INHBE 83729 Affinity Capture-MS Homo sapiens 4 FMOD 2331 Affinity Capture-MS Homo sapiens 5 PCDHGB1   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 6 ZBBX   Affinity Capture-MS Homo sapiens 7 KLK15   Affinity Capture-MS Homo sapiens 8 SIRT6   Affinity Capture-MS Homo sapiens 9 CDHR4   Affinity Capture-MS Homo sapiens 10 TMEM87A 25963 Affinity Capture-MS Homo sapiens 11 MSTN   Affinity Capture-MS Homo sapiens 12 C1orf54   Affinity Capture-MS Homo sapiens 13 HLA-DRA 3122 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 14 CMA1   Affinity Capture-MS Homo sapiens 15 GGH 8836 Affinity Capture-MS Homo sapiens 16 CFC1   Affinity Capture-MS Homo sapiens 17 TRGV3   Affinity Capture-MS Homo sapiens 18 SSX6   Affinity Capture-MS Homo sapiens 19 PCDH12 51294 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 20 RYK 6259 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 21 PRG2   Affinity Capture-MS Homo sapiens 22 CANT1 124583 Affinity Capture-MS Homo sapiens 23 SPSB4   Affinity Capture-MS Homo sapiens 24 FUT8 2530 Affinity Capture-MS Homo sapiens 25 BTNL2   Affinity Capture-MS Homo sapiens 26 OIT3 170392 Affinity Capture-MS Homo sapiens 27 LOC254896   Affinity Capture-MS Homo sapiens 28 ADAMTS13 11093 Affinity Capture-MS Homo sapiens 29 LYZL1   Affinity Capture-MS Homo sapiens 30 CLU 1191 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 31 SLAMF1 6504 Affinity Capture-MS Homo sapiens 32 SOX2   Affinity Capture-MS Homo sapiens 33 SFTPC   Affinity Capture-MS Homo sapiens 34 CTSG 1511 Affinity Capture-MS Homo sapiens 35 DDX39A 10212 Affinity Capture-MS Homo sapiens 36 DCANP1   Affinity Capture-MS Homo sapiens 37 C1QB 713 Affinity Capture-MS Homo sapiens 38 CHRNA9   Affinity Capture-MS Homo sapiens 39 TMEM106A   Affinity Capture-MS Homo sapiens 40 BRICD5   Affinity Capture-MS Homo sapiens 41 NXPH3   Affinity Capture-MS Homo sapiens 42 SEC62 7095 Proximity Label-MS Homo sapiens 43 FIBIN   Affinity Capture-MS Homo sapiens 44 LAG3   Affinity Capture-MS Homo sapiens 45 CRISP2   Affinity Capture-MS Homo sapiens 46 LYPD1   Affinity Capture-MS Homo sapiens 47 NXPH2   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 48 SIRPD   Affinity Capture-MS Homo sapiens 49 PSAP 5660 Two-hybrid Homo sapiens 50 XAGE1B   Affinity Capture-MS Homo sapiens 51 DNAJB9 4189 Affinity Capture-MS Homo sapiens 52 LYPD6   Affinity Capture-MS Homo sapiens 53 CD160   Affinity Capture-MS Homo sapiens 54 EDN3   Affinity Capture-MS Homo sapiens 55 NUP210P1   Affinity Capture-MS Homo sapiens 56 ISLR 3671 Affinity Capture-MS Homo sapiens 57 PTCH1   Affinity Capture-MS Homo sapiens 58 SDF2L1 23753 Affinity Capture-MS Homo sapiens 59 DKKL1   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens View the network

Pathways in which CELSR1 is involved

No pathways found