Gene description for H6PD
Gene name hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Gene symbol H6PD
Other names/aliases CORTRD1
G6PDH
GDH
Species Homo sapiens
 Database cross references - H6PD
ExoCarta ExoCarta_9563
Vesiclepedia VP_9563
Entrez Gene 9563
HGNC 4795
MIM 138090
UniProt O95479  
 H6PD identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for H6PD
Molecular Function
    glucose-6-phosphate dehydrogenase activity GO:0004345 IBA
    glucose-6-phosphate dehydrogenase activity GO:0004345 IDA
    6-phosphogluconolactonase activity GO:0017057 ISS
    carbohydrate binding GO:0030246 IEA
    glucose 1-dehydrogenase (NAD+) activity GO:0047934 IEA
    glucose 1-dehydrogenase (NADP+) activity GO:0047935 IEA
    NADP binding GO:0050661 IEA
Biological Process
    glucose metabolic process GO:0006006 IBA
    pentose-phosphate shunt, oxidative branch GO:0009051 IBA
    pentose-phosphate shunt, oxidative branch GO:0009051 IMP
    response to nutrient levels GO:0031667 IEA
    response to alcohol GO:0097305 IEA
    regulation of cortisol biosynthetic process GO:2000064 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum lumen GO:0005788 IDA
 Experiment description of studies that identified H6PD in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for H6PD
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCL3  
Affinity Capture-MS Homo sapiens
2 SKP1 6500
Affinity Capture-MS Homo sapiens
3 HSPA5 3309
Affinity Capture-MS Homo sapiens
4 CCL3L1  
Affinity Capture-MS Homo sapiens
5 PTGDS  
Affinity Capture-MS Homo sapiens
6 CSH1  
Affinity Capture-MS Homo sapiens
7 TAZ  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 GGH 8836
Affinity Capture-MS Homo sapiens
9 PDGFRA 5156
Affinity Capture-MS Homo sapiens
10 PRG2  
Affinity Capture-MS Homo sapiens
11 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
12 ANTXR1 84168
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PTDSS1 9791
Affinity Capture-MS Homo sapiens
14 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 PARK2  
Affinity Capture-MS Homo sapiens
16 RPA3 6119
Proximity Label-MS Homo sapiens
17 FBXO2 26232
Affinity Capture-MS Homo sapiens
18 SARAF  
Affinity Capture-MS Homo sapiens
19 SCGB2A2  
Affinity Capture-MS Homo sapiens
20 DNAJB9 4189
Affinity Capture-MS Homo sapiens
21 SDF2L1 23753
Affinity Capture-MS Homo sapiens
22 C1QTNF7  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which H6PD is involved
No pathways found





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