Gene description for NRXN3
Gene name neurexin 3
Gene symbol NRXN3
Other names/aliases C14orf60
Species Homo sapiens
 Database cross references - NRXN3
ExoCarta ExoCarta_9369
Entrez Gene 9369
HGNC 8010
MIM 600567
UniProt Q9Y4C0   Q9HDB5  
 NRXN3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for NRXN3
Molecular Function
    cell adhesion molecule binding GO:0050839 TAS
    transmembrane signaling receptor activity GO:0004888 NAS
    receptor activity GO:0004872 TAS
    metal ion binding GO:0046872 IEA
    neuroligin family protein binding GO:0097109 TAS
    calcium channel regulator activity GO:0005246 IEA
Biological Process
    learning GO:0007612 IGI
    signal transduction GO:0007165 NAS
    adult behavior GO:0030534 IGI
    social behavior GO:0035176 IGI
    vocalization behavior GO:0071625 IGI
    positive regulation of synapse assembly GO:0051965 IEA
    neuron cell-cell adhesion GO:0007158 TAS
    axon guidance GO:0007411 TAS
    angiogenesis GO:0001525 ISS
    synaptic transmission GO:0007268 IEA
    positive regulation of synapse maturation GO:0090129 IEA
    neurotransmitter secretion GO:0007269 IEA
    synapse assembly GO:0007416 IEA
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    cell GO:0005623 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified NRXN3 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for NRXN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NLGN2  
Reconstituted Complex Homo sapiens
2 MLLT4 4301
Two-hybrid Homo sapiens
3 NLGN1  
Reconstituted Complex Homo sapiens
4 CASK 8573
Invitro Homo sapiens
Two-hybrid Homo sapiens
5 NLGN3  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which NRXN3 is involved
No pathways found

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