Gene description for PGLYRP1
Gene name peptidoglycan recognition protein 1
Gene symbol PGLYRP1
Other names/aliases PGLYRP
PGRP
PGRP-S
PGRPS
TAG7
TNFSF3L
Species Homo sapiens
 Database cross references - PGLYRP1
ExoCarta ExoCarta_8993
Entrez Gene 8993
HGNC 8904
MIM 604963
UniProt O75594  
 PGLYRP1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for PGLYRP1
Molecular Function
    peptidoglycan receptor activity GO:0016019 IDA
    zinc ion binding GO:0008270 IEA
    N-acetylmuramoyl-L-alanine amidase activity GO:0008745 IEA
    peptidoglycan binding GO:0042834 IDA
Biological Process
    detection of bacterium GO:0016045 IDA
    defense response to Gram-positive bacterium GO:0050830 IDA
    negative regulation of inflammatory response GO:0050728 IEA
    negative regulation of natural killer cell differentiation involved in immune response GO:0032827 IEA
    immune response GO:0006955 TAS
    innate immune response GO:0045087 NAS
    pattern recognition receptor signaling pathway GO:0002221 IDA
    peptidoglycan catabolic process GO:0009253 IEA
    negative regulation of interferon-gamma production GO:0032689 IEA
    growth of symbiont in host GO:0044117 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    extracellular region GO:0005576 NAS
 Experiment description of studies that identified PGLYRP1 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PGLYRP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PGLYRP1 is involved
No pathways found





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