Gene description for FGF18
Gene name fibroblast growth factor 18
Gene symbol FGF18
Other names/aliases FGF-18
ZFGF5
Species Homo sapiens
 Database cross references - FGF18
ExoCarta ExoCarta_8817
Entrez Gene 8817
HGNC 3674
MIM 603726
UniProt O76093  
 FGF18 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for FGF18
Molecular Function
    growth factor activity GO:0008083 IEA
    type 2 fibroblast growth factor receptor binding GO:0005111 IDA
    type 1 fibroblast growth factor receptor binding GO:0005105 IDA
Biological Process
    positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IC
    nervous system development GO:0007399 IEA
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    positive regulation of cell proliferation GO:0008284 IEA
    regulation of endothelial cell proliferation GO:0001936 IDA
    endochondral ossification GO:0001958 IEA
    cell-cell signaling GO:0007267 TAS
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    chondrocyte development GO:0002063 IEA
    anatomical structure morphogenesis GO:0009653 TAS
    signal transduction GO:0007165 TAS
    intramembranous ossification GO:0001957 IEA
    angiogenesis GO:0001525 IEA
    insulin receptor signaling pathway GO:0008286 TAS
    positive regulation of MAP kinase activity GO:0043406 IDA
    positive regulation of chondrocyte differentiation GO:0032332 IEA
    positive regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2000546 IDA
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    regulation of sprouting angiogenesis GO:1903670 IDA
    innate immune response GO:0045087 TAS
    lung development GO:0030324 IEA
Subcellular Localization
    nucleolus GO:0005730 IDA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 TAS
 Experiment description of studies that identified FGF18 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for FGF18
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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